Micro nutrients as immunomodulators in the ageing population: a focus on inflammation and autoimmunity
Abstract Immunosenescence, the slow degradation of immune function over time that is a hallmark and driver of aging, makes older people much more likely to be killed by common infections (such as flu) than young adults, but it also contributes greatly to rates of chronic inflammation in later life....
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BMC
2024-12-01
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| Series: | Immunity & Ageing |
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| Online Access: | https://doi.org/10.1186/s12979-024-00492-7 |
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| author | Bhavani Sowndharya Balamurugan Mathan Muthu Chinnakannu Marimuthu Vickram Agaram Sundaram Bharath Saravanan Prasanth Chandrababu Hitesh Chopra Tabarak Malik |
| author_facet | Bhavani Sowndharya Balamurugan Mathan Muthu Chinnakannu Marimuthu Vickram Agaram Sundaram Bharath Saravanan Prasanth Chandrababu Hitesh Chopra Tabarak Malik |
| author_sort | Bhavani Sowndharya Balamurugan |
| collection | DOAJ |
| description | Abstract Immunosenescence, the slow degradation of immune function over time that is a hallmark and driver of aging, makes older people much more likely to be killed by common infections (such as flu) than young adults, but it also contributes greatly to rates of chronic inflammation in later life. Such micro nutrients are crucial for modulating effective immune responses and their deficiencies have been associated with dysfunctional immunity in the elderly. In this review, we specifically focused on the contribution of major micro nutrients (Vitamins A, D and E, Vitamin C; Zinc and Selenium) as immunomodulators in ageing population especially related to inflame-ageing process including autoimmunity. This review will cover these hologenomic interactions, including how micro nutrients can modulate immune cell function and/or cytokine production to benefit their hosts with healthy mucous-associated immunity along with a sustainable immunologic homeostasis. For example, it points out the modulatory effects of vitamin D on both innate and adaptive immunity, with a specific focus on its ability to suppress pro-inflammatory cytokines synthesis while enhancing regulatory T-cell function. In the same context, also zinc is described as important nutrient for thymic function and T-cell differentiation but exhibits immunomodulatory functions by decreasing inflammation. In addition, the review will go over how micro nutrient deficiencies increase systemic chronic low-grade inflammation and, inflammaging as well as actually enhance autoimmune pathologies in old age. It assesses the potential role of additional targeted nutritional supplementation with micro nutrients to counteract these effects, promoting wider immune resilience in older adults. This review collates the current evidence and highlights the role of adequate micro nutrient intake on inflammation and autoimmunity during ageing, providing plausible origins for nutritional interventions to promote healthy immune aging. |
| format | Article |
| id | doaj-art-4b23544e9214469eaef031ce75eba40c |
| institution | DOAJ |
| issn | 1742-4933 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Immunity & Ageing |
| spelling | doaj-art-4b23544e9214469eaef031ce75eba40c2025-08-20T02:43:36ZengBMCImmunity & Ageing1742-49332024-12-0121111510.1186/s12979-024-00492-7Micro nutrients as immunomodulators in the ageing population: a focus on inflammation and autoimmunityBhavani Sowndharya Balamurugan0Mathan Muthu Chinnakannu Marimuthu1Vickram Agaram Sundaram2Bharath Saravanan3Prasanth Chandrababu4Hitesh Chopra5Tabarak Malik6Department of Biotechnology, Saveetha School of Engineering, Saveetha Institute of Medical and Technical SciencesDepartment of Biotechnology, Saveetha School of Engineering, Saveetha Institute of Medical and Technical SciencesDepartment of Biotechnology, Saveetha School of Engineering, Saveetha Institute of Medical and Technical SciencesDepartment of Biotechnology, Saveetha School of Engineering, Saveetha Institute of Medical and Technical SciencesDepartment of Biotechnology, Saveetha School of Engineering, Saveetha Institute of Medical and Technical SciencesCentre for Research Impact & Outcome, Chitkara College of Pharmacy, Chitkara UniversityDepartment of Biomedical Sciences, Institute of Health, Jimma UniversityAbstract Immunosenescence, the slow degradation of immune function over time that is a hallmark and driver of aging, makes older people much more likely to be killed by common infections (such as flu) than young adults, but it also contributes greatly to rates of chronic inflammation in later life. Such micro nutrients are crucial for modulating effective immune responses and their deficiencies have been associated with dysfunctional immunity in the elderly. In this review, we specifically focused on the contribution of major micro nutrients (Vitamins A, D and E, Vitamin C; Zinc and Selenium) as immunomodulators in ageing population especially related to inflame-ageing process including autoimmunity. This review will cover these hologenomic interactions, including how micro nutrients can modulate immune cell function and/or cytokine production to benefit their hosts with healthy mucous-associated immunity along with a sustainable immunologic homeostasis. For example, it points out the modulatory effects of vitamin D on both innate and adaptive immunity, with a specific focus on its ability to suppress pro-inflammatory cytokines synthesis while enhancing regulatory T-cell function. In the same context, also zinc is described as important nutrient for thymic function and T-cell differentiation but exhibits immunomodulatory functions by decreasing inflammation. In addition, the review will go over how micro nutrient deficiencies increase systemic chronic low-grade inflammation and, inflammaging as well as actually enhance autoimmune pathologies in old age. It assesses the potential role of additional targeted nutritional supplementation with micro nutrients to counteract these effects, promoting wider immune resilience in older adults. This review collates the current evidence and highlights the role of adequate micro nutrient intake on inflammation and autoimmunity during ageing, providing plausible origins for nutritional interventions to promote healthy immune aging.https://doi.org/10.1186/s12979-024-00492-7ImmunosenescenceMicronutrientsImmune modulationInflammationAutoimmunityAgeing population |
| spellingShingle | Bhavani Sowndharya Balamurugan Mathan Muthu Chinnakannu Marimuthu Vickram Agaram Sundaram Bharath Saravanan Prasanth Chandrababu Hitesh Chopra Tabarak Malik Micro nutrients as immunomodulators in the ageing population: a focus on inflammation and autoimmunity Immunity & Ageing Immunosenescence Micronutrients Immune modulation Inflammation Autoimmunity Ageing population |
| title | Micro nutrients as immunomodulators in the ageing population: a focus on inflammation and autoimmunity |
| title_full | Micro nutrients as immunomodulators in the ageing population: a focus on inflammation and autoimmunity |
| title_fullStr | Micro nutrients as immunomodulators in the ageing population: a focus on inflammation and autoimmunity |
| title_full_unstemmed | Micro nutrients as immunomodulators in the ageing population: a focus on inflammation and autoimmunity |
| title_short | Micro nutrients as immunomodulators in the ageing population: a focus on inflammation and autoimmunity |
| title_sort | micro nutrients as immunomodulators in the ageing population a focus on inflammation and autoimmunity |
| topic | Immunosenescence Micronutrients Immune modulation Inflammation Autoimmunity Ageing population |
| url | https://doi.org/10.1186/s12979-024-00492-7 |
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