Bone Health in a Nonjaundiced Population of Children with Biliary Atresia
Objectives. To assess bone health in a cohort of nonjaundiced children with biliary atresia (BA) and the effect of growth and development on bone outcomes. Methods. Children ages one to eighteen years receiving care from Children's Hospital of Philadelphia were recruited. Each child was seen o...
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| Format: | Article |
| Language: | English |
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Wiley
2009-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2009/387029 |
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| author | Rachel A. Kramer Babette S. Zemel Jessica L. Arvay-Nezu Virginia A. Stallings Mary B. Leonard Barbara A. Haber |
| author_facet | Rachel A. Kramer Babette S. Zemel Jessica L. Arvay-Nezu Virginia A. Stallings Mary B. Leonard Barbara A. Haber |
| author_sort | Rachel A. Kramer |
| collection | DOAJ |
| description | Objectives. To assess bone health in a cohort of nonjaundiced children with biliary atresia (BA) and the effect of growth and development on bone outcomes.
Methods. Children ages one to eighteen years receiving care from Children's Hospital of Philadelphia were recruited. Each child was seen once and assessed for growth, pubertal development, concurrent medications, bilirubin, ALT, albumin, vitamin D status, bone mineral density (BMD), and bone mineral content (BMC) of the lumbar spine and whole body. Results. BMD declined significantly with age, and upon further analysis with a well-phenotyped control cohort, it was found that BMC was significantly decreased for both lumbar spine and whole body, even after adjustment for confounding variables. An age interaction was identified, with older subjects having a significantly greater impairment in BMC. Conclusions. These preliminary results demonstrate that children with BA, including those without jaundice, are likely to have compromised bone health even when accounting for height and puberty, which are common confounding factors in chronic disease. Further investigation is needed to identify the determinants of poor bone mineral status and to develop strategies to prevent osteoporosis later in life. |
| format | Article |
| id | doaj-art-4b14af15db4543e78eda242ab22c2efb |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-4b14af15db4543e78eda242ab22c2efb2025-08-20T03:36:39ZengWileyGastroenterology Research and Practice1687-61211687-630X2009-01-01200910.1155/2009/387029387029Bone Health in a Nonjaundiced Population of Children with Biliary AtresiaRachel A. Kramer0Babette S. Zemel1Jessica L. Arvay-Nezu2Virginia A. Stallings3Mary B. Leonard4Barbara A. Haber5The Division of Gastroenterology, Hepatology & Nutrition, Children's Hospital of Philadelphia, PA 19104, USAThe Division of Gastroenterology, Hepatology & Nutrition, Children's Hospital of Philadelphia, PA 19104, USAThe Division of Gastroenterology, Hepatology & Nutrition, Children's Hospital of Philadelphia, PA 19104, USAThe Division of Gastroenterology, Hepatology & Nutrition, Children's Hospital of Philadelphia, PA 19104, USAThe Division of Nephrology, Children's Hospital of Philadelphia, PA 19104, USAThe Division of Gastroenterology, Hepatology & Nutrition, Children's Hospital of Philadelphia, PA 19104, USAObjectives. To assess bone health in a cohort of nonjaundiced children with biliary atresia (BA) and the effect of growth and development on bone outcomes. Methods. Children ages one to eighteen years receiving care from Children's Hospital of Philadelphia were recruited. Each child was seen once and assessed for growth, pubertal development, concurrent medications, bilirubin, ALT, albumin, vitamin D status, bone mineral density (BMD), and bone mineral content (BMC) of the lumbar spine and whole body. Results. BMD declined significantly with age, and upon further analysis with a well-phenotyped control cohort, it was found that BMC was significantly decreased for both lumbar spine and whole body, even after adjustment for confounding variables. An age interaction was identified, with older subjects having a significantly greater impairment in BMC. Conclusions. These preliminary results demonstrate that children with BA, including those without jaundice, are likely to have compromised bone health even when accounting for height and puberty, which are common confounding factors in chronic disease. Further investigation is needed to identify the determinants of poor bone mineral status and to develop strategies to prevent osteoporosis later in life.http://dx.doi.org/10.1155/2009/387029 |
| spellingShingle | Rachel A. Kramer Babette S. Zemel Jessica L. Arvay-Nezu Virginia A. Stallings Mary B. Leonard Barbara A. Haber Bone Health in a Nonjaundiced Population of Children with Biliary Atresia Gastroenterology Research and Practice |
| title | Bone Health in a Nonjaundiced Population of Children with Biliary Atresia |
| title_full | Bone Health in a Nonjaundiced Population of Children with Biliary Atresia |
| title_fullStr | Bone Health in a Nonjaundiced Population of Children with Biliary Atresia |
| title_full_unstemmed | Bone Health in a Nonjaundiced Population of Children with Biliary Atresia |
| title_short | Bone Health in a Nonjaundiced Population of Children with Biliary Atresia |
| title_sort | bone health in a nonjaundiced population of children with biliary atresia |
| url | http://dx.doi.org/10.1155/2009/387029 |
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