Protection against Experimental Melioidosis following Immunisation with a Lipopolysaccharide-Protein Conjugate

Melioidosis is a severe infectious disease caused by Burkholderia pseudomallei. It is refractory to antibiotic treatment and there is currently no licensed vaccine. In this report we detail the construction and protective efficacy of a polysaccharide-protein conjugate composed of B. pseudomallei lip...

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Main Authors: Andrew E. Scott, Sarah A. Ngugi, Thomas R. Laws, David Corser, Claire L. Lonsdale, Riccardo V. D’Elia, Richard W. Titball, E. Diane Williamson, Timothy P. Atkins, Joann L. Prior
Format: Article
Language:English
Published: Wiley 2014-01-01
Series:Journal of Immunology Research
Online Access:http://dx.doi.org/10.1155/2014/392170
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author Andrew E. Scott
Sarah A. Ngugi
Thomas R. Laws
David Corser
Claire L. Lonsdale
Riccardo V. D’Elia
Richard W. Titball
E. Diane Williamson
Timothy P. Atkins
Joann L. Prior
author_facet Andrew E. Scott
Sarah A. Ngugi
Thomas R. Laws
David Corser
Claire L. Lonsdale
Riccardo V. D’Elia
Richard W. Titball
E. Diane Williamson
Timothy P. Atkins
Joann L. Prior
author_sort Andrew E. Scott
collection DOAJ
description Melioidosis is a severe infectious disease caused by Burkholderia pseudomallei. It is refractory to antibiotic treatment and there is currently no licensed vaccine. In this report we detail the construction and protective efficacy of a polysaccharide-protein conjugate composed of B. pseudomallei lipopolysaccharide and the Hc fragment of tetanus toxin. Immunisation of mice with the lipopolysaccharide-conjugate led to significantly reduced bacterial burdens in the spleen 48 hours after challenge and afforded significant protection against a lethal challenge with B. pseudomallei. The conjugate generated significantly higher levels of antigen-specific IgG1 and IgG2a than in lipopolysaccharide-immunised mice. Immunisation with the conjugate also demonstrated a bias towards Th1 type responses, evidenced by high levels of IgG2a. In contrast, immunisation with unconjugated lipopolysaccharide evoked almost no IgG2a demonstrating a bias towards Th2 type responses. This study demonstrates the effectiveness of this approach in the development of an efficacious and protective vaccine against melioidosis.
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institution Kabale University
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publishDate 2014-01-01
publisher Wiley
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series Journal of Immunology Research
spelling doaj-art-4b148131007d4b5cb25b8f4c6c672a8e2025-08-20T03:36:39ZengWileyJournal of Immunology Research2314-88612314-71562014-01-01201410.1155/2014/392170392170Protection against Experimental Melioidosis following Immunisation with a Lipopolysaccharide-Protein ConjugateAndrew E. Scott0Sarah A. Ngugi1Thomas R. Laws2David Corser3Claire L. Lonsdale4Riccardo V. D’Elia5Richard W. Titball6E. Diane Williamson7Timothy P. Atkins8Joann L. Prior9Defence Science and Technology Laboratory, Porton Down, Salisbury SP4 0JQ, UKDefence Science and Technology Laboratory, Porton Down, Salisbury SP4 0JQ, UKDefence Science and Technology Laboratory, Porton Down, Salisbury SP4 0JQ, UKFleet Bioprocessing Ltd., Pale Lane Farm, Hartley Wintney RG27 8DH, UKDefence Science and Technology Laboratory, Porton Down, Salisbury SP4 0JQ, UKDefence Science and Technology Laboratory, Porton Down, Salisbury SP4 0JQ, UKCollege of Life and Environmental Sciences, University of Exeter, Exeter EX4 4QD, UKDefence Science and Technology Laboratory, Porton Down, Salisbury SP4 0JQ, UKDefence Science and Technology Laboratory, Porton Down, Salisbury SP4 0JQ, UKDefence Science and Technology Laboratory, Porton Down, Salisbury SP4 0JQ, UKMelioidosis is a severe infectious disease caused by Burkholderia pseudomallei. It is refractory to antibiotic treatment and there is currently no licensed vaccine. In this report we detail the construction and protective efficacy of a polysaccharide-protein conjugate composed of B. pseudomallei lipopolysaccharide and the Hc fragment of tetanus toxin. Immunisation of mice with the lipopolysaccharide-conjugate led to significantly reduced bacterial burdens in the spleen 48 hours after challenge and afforded significant protection against a lethal challenge with B. pseudomallei. The conjugate generated significantly higher levels of antigen-specific IgG1 and IgG2a than in lipopolysaccharide-immunised mice. Immunisation with the conjugate also demonstrated a bias towards Th1 type responses, evidenced by high levels of IgG2a. In contrast, immunisation with unconjugated lipopolysaccharide evoked almost no IgG2a demonstrating a bias towards Th2 type responses. This study demonstrates the effectiveness of this approach in the development of an efficacious and protective vaccine against melioidosis.http://dx.doi.org/10.1155/2014/392170
spellingShingle Andrew E. Scott
Sarah A. Ngugi
Thomas R. Laws
David Corser
Claire L. Lonsdale
Riccardo V. D’Elia
Richard W. Titball
E. Diane Williamson
Timothy P. Atkins
Joann L. Prior
Protection against Experimental Melioidosis following Immunisation with a Lipopolysaccharide-Protein Conjugate
Journal of Immunology Research
title Protection against Experimental Melioidosis following Immunisation with a Lipopolysaccharide-Protein Conjugate
title_full Protection against Experimental Melioidosis following Immunisation with a Lipopolysaccharide-Protein Conjugate
title_fullStr Protection against Experimental Melioidosis following Immunisation with a Lipopolysaccharide-Protein Conjugate
title_full_unstemmed Protection against Experimental Melioidosis following Immunisation with a Lipopolysaccharide-Protein Conjugate
title_short Protection against Experimental Melioidosis following Immunisation with a Lipopolysaccharide-Protein Conjugate
title_sort protection against experimental melioidosis following immunisation with a lipopolysaccharide protein conjugate
url http://dx.doi.org/10.1155/2014/392170
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