Hyper-IgE syndrome: A rare case report
Hyper-IgE syndrome (HIES) is a rare and sporadic primary immunodeficiency usually characterized by atopic dermatitis, recurrent skin staphylococcal infections, recurrent pulmonary infections, and elevated IgE levels. Due to the rarity of the syndrome and its nonspecific and wide presentation, the di...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-08-01
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| Series: | Journal of Allergy and Clinical Immunology: Global |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772829325001262 |
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| author | Lee Smith, PhD Ahmed Rafei, MD Susanna Caminada, MD Salma Barakat, MD Sami Medani Abd Elwahab, MD Damiano Pizzol, PhD Abdelmounem Eltayeb Abdo, PhD |
| author_facet | Lee Smith, PhD Ahmed Rafei, MD Susanna Caminada, MD Salma Barakat, MD Sami Medani Abd Elwahab, MD Damiano Pizzol, PhD Abdelmounem Eltayeb Abdo, PhD |
| author_sort | Lee Smith, PhD |
| collection | DOAJ |
| description | Hyper-IgE syndrome (HIES) is a rare and sporadic primary immunodeficiency usually characterized by atopic dermatitis, recurrent skin staphylococcal infections, recurrent pulmonary infections, and elevated IgE levels. Due to the rarity of the syndrome and its nonspecific and wide presentation, the diagnosis is difficult and arises with other diagnoses including other types of primitive chronic granulomatous disease or acquired immunodeficiency, severe atopic dermatitis, or cystic fibrosis or chronic respiratory infection as tuberculosis. To date, there is no gold standard management and treatments aim to relieve symptoms and avoid complications. We report on a 30-year-old female with a long-time misdiagnosed HIES. |
| format | Article |
| id | doaj-art-4b139311fcfc4b56ad4bc7b6bc37fdc7 |
| institution | DOAJ |
| issn | 2772-8293 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Allergy and Clinical Immunology: Global |
| spelling | doaj-art-4b139311fcfc4b56ad4bc7b6bc37fdc72025-08-20T03:01:41ZengElsevierJournal of Allergy and Clinical Immunology: Global2772-82932025-08-014310052510.1016/j.jacig.2025.100525Hyper-IgE syndrome: A rare case reportLee Smith, PhD0Ahmed Rafei, MD1Susanna Caminada, MD2Salma Barakat, MD3Sami Medani Abd Elwahab, MD4Damiano Pizzol, PhD5Abdelmounem Eltayeb Abdo, PhD6Centre for Health, Performance and Wellbeing, Anglia Ruskin University, Cambridge, United KingdomNational Centre of Gastrointestinal and Liver Disease, Ibn Sina Hospital, Khartoum, SudanHealth Unit Eni, Rome, ItalyNational Centre of Gastrointestinal and Liver Disease, Ibn Sina Hospital, Khartoum, SudanNational Centre of Gastrointestinal and Liver Disease, Ibn Sina Hospital, Khartoum, Sudan; Department of Surgery, University Hospital Galway, Galway, IrelandHealth Unit Eni, Maputo, Mozambique; Corresponding author: Damiano Pizzol, MD, PhD, Health Unit, Eni Mozambique, Rua dos Deportistads 733, 1113 Maputo.National Centre of Gastrointestinal and Liver Disease, Ibn Sina Hospital, Khartoum, SudanHyper-IgE syndrome (HIES) is a rare and sporadic primary immunodeficiency usually characterized by atopic dermatitis, recurrent skin staphylococcal infections, recurrent pulmonary infections, and elevated IgE levels. Due to the rarity of the syndrome and its nonspecific and wide presentation, the diagnosis is difficult and arises with other diagnoses including other types of primitive chronic granulomatous disease or acquired immunodeficiency, severe atopic dermatitis, or cystic fibrosis or chronic respiratory infection as tuberculosis. To date, there is no gold standard management and treatments aim to relieve symptoms and avoid complications. We report on a 30-year-old female with a long-time misdiagnosed HIES.http://www.sciencedirect.com/science/article/pii/S2772829325001262Hyper-IgE syndromeJob syndromeHIESIgE |
| spellingShingle | Lee Smith, PhD Ahmed Rafei, MD Susanna Caminada, MD Salma Barakat, MD Sami Medani Abd Elwahab, MD Damiano Pizzol, PhD Abdelmounem Eltayeb Abdo, PhD Hyper-IgE syndrome: A rare case report Journal of Allergy and Clinical Immunology: Global Hyper-IgE syndrome Job syndrome HIES IgE |
| title | Hyper-IgE syndrome: A rare case report |
| title_full | Hyper-IgE syndrome: A rare case report |
| title_fullStr | Hyper-IgE syndrome: A rare case report |
| title_full_unstemmed | Hyper-IgE syndrome: A rare case report |
| title_short | Hyper-IgE syndrome: A rare case report |
| title_sort | hyper ige syndrome a rare case report |
| topic | Hyper-IgE syndrome Job syndrome HIES IgE |
| url | http://www.sciencedirect.com/science/article/pii/S2772829325001262 |
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