Boosting curcumin bioavailability with egg white protein aerogels: A sustainable supercritical CO₂-based approach for enhanced bioaccessibility, antioxidant activity, and anti-inflammatory effects
This study introduces a novel approach to impregnate curcumin into egg white protein (EWP) aerogels using supercritical carbon dioxide (SC-CO2) technology, with aerogels fabricated through two different gelation methods. SC-CO2-assisted impregnation resulted in uniform curcumin distribution within t...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-06-01
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| Series: | Future Foods |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666833524002351 |
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| author | Farhad Alavi Ozan N. Ciftci |
| author_facet | Farhad Alavi Ozan N. Ciftci |
| author_sort | Farhad Alavi |
| collection | DOAJ |
| description | This study introduces a novel approach to impregnate curcumin into egg white protein (EWP) aerogels using supercritical carbon dioxide (SC-CO2) technology, with aerogels fabricated through two different gelation methods. SC-CO2-assisted impregnation resulted in uniform curcumin distribution within the aerogel matrix, significantly enhancing its solubility, antioxidant activity, bioaccessibility, and bioactivity compared to free curcumin. Digestibility analysis confirmed the efficient breakdown of EWP aerogels by digestive enzymes, emphasizing their potential as food-grade, nutritious carriers for controlled release and nutraceutical delivery. Notably, the newly developed cold-set gelation method for EWP aerogel fabrication outperformed conventional heat-set gelation. Aerogels produced via cold-set gelation exhibited lower density, higher porosity, and greater curcumin loading capacity. These aerogels also demonstrated improved antioxidant activity and higher curcumin transport across Caco-2 cell monolayers. In vitro studies further revealed significant anti-inflammatory effects of the curcumin-impregnated aerogels in Caco-2 cells. These findings highlight the synergy between cold-set gelation and SC-CO2 impregnation technology, presenting an innovative strategy to enhance curcumin loading, release, and bioavailability in EWP aerogels for potential nutraceutical applications. |
| format | Article |
| id | doaj-art-4b1387dedc5948c7b3bc7605878b1258 |
| institution | Kabale University |
| issn | 2666-8335 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Future Foods |
| spelling | doaj-art-4b1387dedc5948c7b3bc7605878b12582025-01-16T04:29:20ZengElsevierFuture Foods2666-83352025-06-0111100532Boosting curcumin bioavailability with egg white protein aerogels: A sustainable supercritical CO₂-based approach for enhanced bioaccessibility, antioxidant activity, and anti-inflammatory effectsFarhad Alavi0Ozan N. Ciftci1Department of Food Science and Technology, University of Nebraska-Lincoln, Lincoln, NE 68588-6205, USADepartment of Food Science and Technology, University of Nebraska-Lincoln, Lincoln, NE 68588-6205, USA; Department of Biological Systems Engineering, University of Nebraska-Lincoln, Lincoln, NE 68583-0726, USA; Corresponding author at: 264 Food Innovation Center, Lincoln, NE 68588-6205, USA.This study introduces a novel approach to impregnate curcumin into egg white protein (EWP) aerogels using supercritical carbon dioxide (SC-CO2) technology, with aerogels fabricated through two different gelation methods. SC-CO2-assisted impregnation resulted in uniform curcumin distribution within the aerogel matrix, significantly enhancing its solubility, antioxidant activity, bioaccessibility, and bioactivity compared to free curcumin. Digestibility analysis confirmed the efficient breakdown of EWP aerogels by digestive enzymes, emphasizing their potential as food-grade, nutritious carriers for controlled release and nutraceutical delivery. Notably, the newly developed cold-set gelation method for EWP aerogel fabrication outperformed conventional heat-set gelation. Aerogels produced via cold-set gelation exhibited lower density, higher porosity, and greater curcumin loading capacity. These aerogels also demonstrated improved antioxidant activity and higher curcumin transport across Caco-2 cell monolayers. In vitro studies further revealed significant anti-inflammatory effects of the curcumin-impregnated aerogels in Caco-2 cells. These findings highlight the synergy between cold-set gelation and SC-CO2 impregnation technology, presenting an innovative strategy to enhance curcumin loading, release, and bioavailability in EWP aerogels for potential nutraceutical applications.http://www.sciencedirect.com/science/article/pii/S2666833524002351AerogelCurcuminSupercriticalProteinBioavailabilityInflammation |
| spellingShingle | Farhad Alavi Ozan N. Ciftci Boosting curcumin bioavailability with egg white protein aerogels: A sustainable supercritical CO₂-based approach for enhanced bioaccessibility, antioxidant activity, and anti-inflammatory effects Future Foods Aerogel Curcumin Supercritical Protein Bioavailability Inflammation |
| title | Boosting curcumin bioavailability with egg white protein aerogels: A sustainable supercritical CO₂-based approach for enhanced bioaccessibility, antioxidant activity, and anti-inflammatory effects |
| title_full | Boosting curcumin bioavailability with egg white protein aerogels: A sustainable supercritical CO₂-based approach for enhanced bioaccessibility, antioxidant activity, and anti-inflammatory effects |
| title_fullStr | Boosting curcumin bioavailability with egg white protein aerogels: A sustainable supercritical CO₂-based approach for enhanced bioaccessibility, antioxidant activity, and anti-inflammatory effects |
| title_full_unstemmed | Boosting curcumin bioavailability with egg white protein aerogels: A sustainable supercritical CO₂-based approach for enhanced bioaccessibility, antioxidant activity, and anti-inflammatory effects |
| title_short | Boosting curcumin bioavailability with egg white protein aerogels: A sustainable supercritical CO₂-based approach for enhanced bioaccessibility, antioxidant activity, and anti-inflammatory effects |
| title_sort | boosting curcumin bioavailability with egg white protein aerogels a sustainable supercritical co₂ based approach for enhanced bioaccessibility antioxidant activity and anti inflammatory effects |
| topic | Aerogel Curcumin Supercritical Protein Bioavailability Inflammation |
| url | http://www.sciencedirect.com/science/article/pii/S2666833524002351 |
| work_keys_str_mv | AT farhadalavi boostingcurcuminbioavailabilitywitheggwhiteproteinaerogelsasustainablesupercriticalco2basedapproachforenhancedbioaccessibilityantioxidantactivityandantiinflammatoryeffects AT ozannciftci boostingcurcuminbioavailabilitywitheggwhiteproteinaerogelsasustainablesupercriticalco2basedapproachforenhancedbioaccessibilityantioxidantactivityandantiinflammatoryeffects |