Leveraging a disulfidptosis-based signature to characterize heterogeneity and optimize treatment in multiple myeloma

Leveraging a disulfidptosis-based signature to characterize heterogeneity and optimize treatment in multiple myeloma

BackgroundDisulfidptosis is an emerging type of programmed cell death related to ROS accumulation and aberrant disulfide bond formation. Multiple myeloma (MM) is the second most prevalent hematologic malignancy characterized by a high synthesis rate of disulfide bond-rich proteins and chronic oxidat...

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Main Authors: Bingxin Zhang, Dong Zheng, Shuxia Zhu, Xinyi Zhang, Quanqiang Wang, Zhili Lin, Ziwei Zheng, Shujuan Zhou, Zixing Chen, Sisi Zheng, Enqing Lan, Luning Cui, Hansen Ying, Yu Zhang, Xuanru Lin, Qiang Zhuang, Honglan Qian, Xudong Hu, Yan Zhuang, Qianying Zhang, Zhouxiang Jin, Songfu Jiang, Yongyong Ma
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Immunology
Subjects:
multiple myeloma
disulfidptosis
prognostic gene signature
tumor microenvironment
oxidative stress
immunotherapy
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1559317/full
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