Rationale and design of SCOPE trial: a prospective, multicentre, open-label, randomised controlled trial to evaluate the overall efficacy and safety of a short-term anticoagulation strategy versus conventional single antiplatelet therapy in patients with severe aortic stenosis without indications for anticoagulation or dual antiplatelet therapy post-transcatheter aortic valve replacement

Rationale and design of SCOPE trial: a prospective, multicentre, open-label, randomised controlled trial to evaluate the overall efficacy and safety of a short-term anticoagulation strategy versus conventional single antiplatelet therapy in patients with severe aortic stenosis without indications for anticoagulation or dual antiplatelet therapy post-transcatheter aortic valve replacement

Introduction While transcatheter aortic valve replacement (TAVR) has become a well-established standard of care for patients with symptomatic severe aortic stenosis, the optimal antithrombotic strategy post-TAVR remains a subject of debate, particularly in patients without clear indications for anti...

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Main Authors: Yang Wang, Yan Li, Lihua Zhang, Ran Liu, Wei Wu, Yang Li, Huiping Zhang, Stuart Pocock, Xinmin Liu, Zhinan Lu, Taiyang Luo, Liang Guo, Fei Yuan, Yi-Da Tang, Yingxuan Zhu, Yunfeng Yan, Guangyuan Song, Zhengming Jiang, SCOPE Investigators
Format: Article
Language:English
Published: BMJ Publishing Group 2025-08-01
Series:BMJ Open
Online Access:https://bmjopen.bmj.com/content/15/8/e098551.full
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