Tissue Biomarkers in Gastric Cancer Treatment: Present and Future

The aggressive nature of gastric cancer often leads to late diagnosis and poor prognosis. Chemotherapy and the more recently added immunotherapy remain key treatments for this disease. Several studies have focused on identifying tissue biomarkers with prognostic and/or predictive roles and therefore...

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Main Authors: Giulia Airò, Virginia Agnetti, Fabiana Pratticò, Marianna Peroni, Simona Bui, Giovanni Mura, Maria Urbanowicz-Nijaki, Eleonora Lai, Marco Puzzoni, Fabiana Contu, Nerina Denaro, Mario Scartozzi, Cinzia Solinas, Chiara Tommasi
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:International Journal of Translational Medicine
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Online Access:https://www.mdpi.com/2673-8937/4/4/45
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author Giulia Airò
Virginia Agnetti
Fabiana Pratticò
Marianna Peroni
Simona Bui
Giovanni Mura
Maria Urbanowicz-Nijaki
Eleonora Lai
Marco Puzzoni
Fabiana Contu
Nerina Denaro
Mario Scartozzi
Cinzia Solinas
Chiara Tommasi
author_facet Giulia Airò
Virginia Agnetti
Fabiana Pratticò
Marianna Peroni
Simona Bui
Giovanni Mura
Maria Urbanowicz-Nijaki
Eleonora Lai
Marco Puzzoni
Fabiana Contu
Nerina Denaro
Mario Scartozzi
Cinzia Solinas
Chiara Tommasi
author_sort Giulia Airò
collection DOAJ
description The aggressive nature of gastric cancer often leads to late diagnosis and poor prognosis. Chemotherapy and the more recently added immunotherapy remain key treatments for this disease. Several studies have focused on identifying tissue biomarkers with prognostic and/or predictive roles and therefore the therapeutic options are rapidly growing. In this narrative review, we summarize the major tissue biomarkers routinely assessed in clinical practice. In addition, we focus on new evidence about emerging tissue biomarkers that could have a predictive role in future therapeutic approaches and also on the potential role of liquid biopsy in this neoplasm.
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institution OA Journals
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publishDate 2024-11-01
publisher MDPI AG
record_format Article
series International Journal of Translational Medicine
spelling doaj-art-4b12e0d06b5148d3a79cc50602eece132025-08-20T02:00:28ZengMDPI AGInternational Journal of Translational Medicine2673-89372024-11-014464066010.3390/ijtm4040045Tissue Biomarkers in Gastric Cancer Treatment: Present and FutureGiulia Airò0Virginia Agnetti1Fabiana Pratticò2Marianna Peroni3Simona Bui4Giovanni Mura5Maria Urbanowicz-Nijaki6Eleonora Lai7Marco Puzzoni8Fabiana Contu9Nerina Denaro10Mario Scartozzi11Cinzia Solinas12Chiara Tommasi13Medical Oncology, University Hospital of Parma, 43100 Parma, ItalyMedical Oncology, University Hospital of Parma, 43100 Parma, ItalyMedical Oncology, University Hospital of Parma, 43100 Parma, ItalyMedical Oncology, University Hospital of Parma, 43100 Parma, ItalyMedical Oncology, University Hospital of Parma, 43100 Parma, ItalyPathological Anatomy, Laboratory Valdès, 81200 Cagliari, ItalyBiobank Lab, Department of Oncobiology and Epigenetics, University of Lodz, 90-237 Lodz, PolandMedical Oncology Unit, University Hospital of Cagliari, University of Cagliari, 09100 Cagliari, ItalyMedical Oncology Unit, University Hospital of Cagliari, University of Cagliari, 09100 Cagliari, ItalyMedical Oncology Unit, University Hospital of Cagliari, University of Cagliari, 09100 Cagliari, ItalyMedical Oncology, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, 20122 Milano, ItalyMedical Oncology Unit, University Hospital of Cagliari, University of Cagliari, 09100 Cagliari, ItalyMedical Oncology Unit, University Hospital of Cagliari, University of Cagliari, 09100 Cagliari, ItalyMedical Oncology, University Hospital of Parma, 43100 Parma, ItalyThe aggressive nature of gastric cancer often leads to late diagnosis and poor prognosis. Chemotherapy and the more recently added immunotherapy remain key treatments for this disease. Several studies have focused on identifying tissue biomarkers with prognostic and/or predictive roles and therefore the therapeutic options are rapidly growing. In this narrative review, we summarize the major tissue biomarkers routinely assessed in clinical practice. In addition, we focus on new evidence about emerging tissue biomarkers that could have a predictive role in future therapeutic approaches and also on the potential role of liquid biopsy in this neoplasm.https://www.mdpi.com/2673-8937/4/4/45gastric cancerbiomarkersimmunotherapytissue biomarker
spellingShingle Giulia Airò
Virginia Agnetti
Fabiana Pratticò
Marianna Peroni
Simona Bui
Giovanni Mura
Maria Urbanowicz-Nijaki
Eleonora Lai
Marco Puzzoni
Fabiana Contu
Nerina Denaro
Mario Scartozzi
Cinzia Solinas
Chiara Tommasi
Tissue Biomarkers in Gastric Cancer Treatment: Present and Future
International Journal of Translational Medicine
gastric cancer
biomarkers
immunotherapy
tissue biomarker
title Tissue Biomarkers in Gastric Cancer Treatment: Present and Future
title_full Tissue Biomarkers in Gastric Cancer Treatment: Present and Future
title_fullStr Tissue Biomarkers in Gastric Cancer Treatment: Present and Future
title_full_unstemmed Tissue Biomarkers in Gastric Cancer Treatment: Present and Future
title_short Tissue Biomarkers in Gastric Cancer Treatment: Present and Future
title_sort tissue biomarkers in gastric cancer treatment present and future
topic gastric cancer
biomarkers
immunotherapy
tissue biomarker
url https://www.mdpi.com/2673-8937/4/4/45
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