Chemoradiotherapy effcacy in squamous cell rectal cancer: a propensity score matched analysis
Introduction. Sporadic cases of squamous cell carcinoma of the rectum (rSCC) do not allow a comparative characterization of tumor aggressiveness and its response to chemoradiotherapy in relation to more common squamous cell entities, in particular, anal squamous cell carcinoma (aSCC). Objective: com...
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Russian Academy of Sciences, Tomsk National Research Medical Center
2023-09-01
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| Series: | Сибирский онкологический журнал |
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| Online Access: | https://www.siboncoj.ru/jour/article/view/2673 |
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| author | V. V. Murzo S. S. Gordeev V. S. Myshlyakov Z. Z. Mamedli |
| author_facet | V. V. Murzo S. S. Gordeev V. S. Myshlyakov Z. Z. Mamedli |
| author_sort | V. V. Murzo |
| collection | DOAJ |
| description | Introduction. Sporadic cases of squamous cell carcinoma of the rectum (rSCC) do not allow a comparative characterization of tumor aggressiveness and its response to chemoradiotherapy in relation to more common squamous cell entities, in particular, anal squamous cell carcinoma (aSCC). Objective: comparative evaluation of the short- and long-term results of chemoradiation therapy in patients with rSCC and aSCC. Material and Methods. In this retrospective study we included patients with nonmetastatic squamous cell carcinoma of the rectum (rSCC) and anal canal squamous cell carcinoma (aSCC) who received chemoradiotherapy and compared them in a 1:1 ratio using propensity-score matching. The dynamics of tumor response to treatment were compared by Kaplan-Meier survival analysis (OS and RFS) followed by Log-Rank verifcation, rate of complete response after 6 months. Results. A total of 15 pairs of matched patients were evaluated. Patients in both groups had reliably similar sex, age, histological grade, initial primary tumor size, differing only in tumor histological subtype. In the aSCC group, 60 % of patients had metastases to pelvic lymph nodes, while in the rSCC group metastases had 46.67 % (p=1). The median follow-up was 44 months. The 3-year OS in the aSCC group of patients was 76.9 %, and 71.4 % in the rSCC group (p=0.567). The 3-year DFS in the aSCC group was 66.7 %, and in the rSCC group 34.7 % (p=0.406). The rate of achieving complete clinical response to CRT after 6 months was 86.7 % for the aSCC group and only 46.7 % for the rSCC group (p=0.05). Organ-saving treatment was achieved in 93.3 % of aSCC patients and 73.3 % of rSCC patients (p=0.33). Conclusion. Overall and recurrence-free survival rates were not signifcantly decreased for rSCC patients relative to aSCC patients. This indicates a similar course and prognosis in the two diseases, but rSCC is characterized by a signifcantly lower rate of complete response to treatment. |
| format | Article |
| id | doaj-art-4b0c1764ec3d422aba1acb89efb7bd3b |
| institution | Kabale University |
| issn | 1814-4861 2312-3168 |
| language | Russian |
| publishDate | 2023-09-01 |
| publisher | Russian Academy of Sciences, Tomsk National Research Medical Center |
| record_format | Article |
| series | Сибирский онкологический журнал |
| spelling | doaj-art-4b0c1764ec3d422aba1acb89efb7bd3b2025-08-20T03:43:40ZrusRussian Academy of Sciences, Tomsk National Research Medical CenterСибирский онкологический журнал1814-48612312-31682023-09-01224142110.21294/1814-4861-2023-22-4-14-211138Chemoradiotherapy effcacy in squamous cell rectal cancer: a propensity score matched analysisV. V. Murzo0S. S. Gordeev1V. S. Myshlyakov2Z. Z. Mamedli3N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of the Russia; I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the RussiaN.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of the Russia; Tyumen State Medical UniversityN.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of the RussiaN.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of the RussiaIntroduction. Sporadic cases of squamous cell carcinoma of the rectum (rSCC) do not allow a comparative characterization of tumor aggressiveness and its response to chemoradiotherapy in relation to more common squamous cell entities, in particular, anal squamous cell carcinoma (aSCC). Objective: comparative evaluation of the short- and long-term results of chemoradiation therapy in patients with rSCC and aSCC. Material and Methods. In this retrospective study we included patients with nonmetastatic squamous cell carcinoma of the rectum (rSCC) and anal canal squamous cell carcinoma (aSCC) who received chemoradiotherapy and compared them in a 1:1 ratio using propensity-score matching. The dynamics of tumor response to treatment were compared by Kaplan-Meier survival analysis (OS and RFS) followed by Log-Rank verifcation, rate of complete response after 6 months. Results. A total of 15 pairs of matched patients were evaluated. Patients in both groups had reliably similar sex, age, histological grade, initial primary tumor size, differing only in tumor histological subtype. In the aSCC group, 60 % of patients had metastases to pelvic lymph nodes, while in the rSCC group metastases had 46.67 % (p=1). The median follow-up was 44 months. The 3-year OS in the aSCC group of patients was 76.9 %, and 71.4 % in the rSCC group (p=0.567). The 3-year DFS in the aSCC group was 66.7 %, and in the rSCC group 34.7 % (p=0.406). The rate of achieving complete clinical response to CRT after 6 months was 86.7 % for the aSCC group and only 46.7 % for the rSCC group (p=0.05). Organ-saving treatment was achieved in 93.3 % of aSCC patients and 73.3 % of rSCC patients (p=0.33). Conclusion. Overall and recurrence-free survival rates were not signifcantly decreased for rSCC patients relative to aSCC patients. This indicates a similar course and prognosis in the two diseases, but rSCC is characterized by a signifcantly lower rate of complete response to treatment.https://www.siboncoj.ru/jour/article/view/2673rectal squamous cell carcinomaanal squamous cell carcinomadefinitive chemoradiotherapypseudorandomisationсomparative effectiveness of chemoradiotherapyretrospective study |
| spellingShingle | V. V. Murzo S. S. Gordeev V. S. Myshlyakov Z. Z. Mamedli Chemoradiotherapy effcacy in squamous cell rectal cancer: a propensity score matched analysis Сибирский онкологический журнал rectal squamous cell carcinoma anal squamous cell carcinoma definitive chemoradiotherapy pseudorandomisation сomparative effectiveness of chemoradiotherapy retrospective study |
| title | Chemoradiotherapy effcacy in squamous cell rectal cancer: a propensity score matched analysis |
| title_full | Chemoradiotherapy effcacy in squamous cell rectal cancer: a propensity score matched analysis |
| title_fullStr | Chemoradiotherapy effcacy in squamous cell rectal cancer: a propensity score matched analysis |
| title_full_unstemmed | Chemoradiotherapy effcacy in squamous cell rectal cancer: a propensity score matched analysis |
| title_short | Chemoradiotherapy effcacy in squamous cell rectal cancer: a propensity score matched analysis |
| title_sort | chemoradiotherapy effcacy in squamous cell rectal cancer a propensity score matched analysis |
| topic | rectal squamous cell carcinoma anal squamous cell carcinoma definitive chemoradiotherapy pseudorandomisation сomparative effectiveness of chemoradiotherapy retrospective study |
| url | https://www.siboncoj.ru/jour/article/view/2673 |
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