Targeting NLRP3 signaling with a novel sulfonylurea compound for the treatment of vascular cognitive impairment and dementia

Targeting NLRP3 signaling with a novel sulfonylurea compound for the treatment of vascular cognitive impairment and dementia

Abstract Background As a key inflammatory factor, the nucleotide-binding oligomerization domain (NOD)-like receptor protein 3 (NLRP3) inflammasome plays a crucial role in neuroinflammation and the progression of neurodegenerative diseases. Dysregulation of NLRP3 signaling can trigger various inflamm...

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Bibliographic Details
Main Authors: Adnan Akif, Thi Thanh My Nguyen, Langni Liu, Xiaotian Xu, Amol Kulkarni, Jianxiong Jiang, Yang Zhang, Jiukuan Hao
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Fluids and Barriers of the CNS
Subjects:
Inflammasome
Inflammation
Ischemia
NLRP3
Vascular dementia
Online Access:https://doi.org/10.1186/s12987-025-00665-6
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