Scutellarin inhibits pyroptosis via selective autophagy degradation of p30/GSDMD and suppression of ASC oligomerization

Scutellarin inhibits pyroptosis via selective autophagy degradation of p30/GSDMD and suppression of ASC oligomerization

Most of the pyroptosis inhibitors targeted Gasdermin D (GSDMD) are functioning by restraining GSDMD-N (p30) oligomerization. For the first time, this work discovered a pyroptosis inhibitor taking effect by degrading p30 and GSDMD. As the principal bioactive constituent in Erigeron breviscapus, scute...

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Bibliographic Details
Main Authors: Danyue Li, Weilv Xu, Suhui He, Xinyue Li, Yumeng Wang, Qian Lv, Nan Chen, Lu Dong, Feng Guo, Fushan Shi
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:Pharmacological Research
Subjects:
Gasgermin D
P30
Scutellarin
Autophagy
Ubiquitin-dependent
TRIM21
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661825000301
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