Course of uveitis in children with juvenile idiopathic arthritis (JIA): Five years follow-up data from a prospective multicenter Inception Cohort of Newly diagnosed patients with JIA (ICON-JIA) study
Abstract Background Juvenile idiopathic arthritis-associated uveitis (JIAU) typically takes a chronic course, frequently leading to ocular complications and often requiring long-term treatment. The present study assesses the 5-years outcome of JIAU by analyzing data from a prospective study initiate...
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BMC
2025-03-01
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| Series: | Arthritis Research & Therapy |
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| Online Access: | https://doi.org/10.1186/s13075-025-03531-w |
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| author | Karoline Baquet-Walscheid Kirsten Minden Martina Niewerth Frank Dressler Ivan Foeldvari Dirk Foell Johannes-Peter Haas Gerd Horneff Anton Hospach Tilmann Kallinich Jasmin Kümmerle-Deschner Kirsten Mönkemöller Christoph Tappeiner Daniel Windschall Jens Klotsche Arnd Heiligenhaus |
| author_facet | Karoline Baquet-Walscheid Kirsten Minden Martina Niewerth Frank Dressler Ivan Foeldvari Dirk Foell Johannes-Peter Haas Gerd Horneff Anton Hospach Tilmann Kallinich Jasmin Kümmerle-Deschner Kirsten Mönkemöller Christoph Tappeiner Daniel Windschall Jens Klotsche Arnd Heiligenhaus |
| author_sort | Karoline Baquet-Walscheid |
| collection | DOAJ |
| description | Abstract Background Juvenile idiopathic arthritis-associated uveitis (JIAU) typically takes a chronic course, frequently leading to ocular complications and often requiring long-term treatment. The present study assesses the 5-years outcome of JIAU by analyzing data from a prospective study initiated in 2010. Methods Data from 75 patients with onset of uveitis after study enrollment, and with a documentation at 5-years follow-up (5yFU) were available for analysis of uveitis characteristics, frequency and predictors of „inactivity on medication “ (defined as inactive uveitis for ≥ 6 months) and „inactivity off medication “ (defined as inactive uveitis for ≥ 6 months off medication). Results At the 5yFU, visual acuity remained good in the majority of eyes (LogMAR < 0.1 in 65.5%; mean LogMAR 0.11 ± 0.31), ocular surgery was required in only 5% of patients, although complications occurred in 46.7% of patients until the 5yFU. Uveitis was inactive in 85.3% of patients, with 77.3% still receiving disease-modifying antirheumatic drugs (DMARDs). Until 5yFU, 82.7% of patients experienced ≥ one episode of „inactivity on medication “ (30.7% once, 37.3% twice, 14.7% three or more times), and 17.3% ≥ one episode of „inactivity off medication “, respectively. Both „inactivity on medication “ as well as „inactivity off medication “ were associated with lower JIA disease activity (cJADAS10; ESR), and with an increased quality of life. Conclusions Despite intensified DMARD treatment, almost half of the children experience JIAU-related ocular complications after 5 years of disease; however, visual acuity mostly remains good. Uveitis inactivity can be achieved frequently, but is often limited in duration. Lower JIA activity appears to correlate with uveitis inactivity on and off medication. |
| format | Article |
| id | doaj-art-4b076bdf30b344f7b3fb49fc614b3271 |
| institution | Kabale University |
| issn | 1478-6362 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | BMC |
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| series | Arthritis Research & Therapy |
| spelling | doaj-art-4b076bdf30b344f7b3fb49fc614b32712025-08-20T03:41:42ZengBMCArthritis Research & Therapy1478-63622025-03-0127111110.1186/s13075-025-03531-wCourse of uveitis in children with juvenile idiopathic arthritis (JIA): Five years follow-up data from a prospective multicenter Inception Cohort of Newly diagnosed patients with JIA (ICON-JIA) studyKaroline Baquet-Walscheid0Kirsten Minden1Martina Niewerth2Frank Dressler3Ivan Foeldvari4Dirk Foell5Johannes-Peter Haas6Gerd Horneff7Anton Hospach8Tilmann Kallinich9Jasmin Kümmerle-Deschner10Kirsten Mönkemöller11Christoph Tappeiner12Daniel Windschall13Jens Klotsche14Arnd Heiligenhaus15Department of Ophthalmology at St. Franziskus HospitalDeutsches Rheumaforschungszentrum BerlinDeutsches Rheumaforschungszentrum BerlinDepartment of Pediatrics, Hannover Medical SchoolHamburg Centre for Paediatric and Adolescent Rheumatology, Schön Klinik Hamburg EilbekDepartment of Pediatric Rheumatology and Immunology, University Hospital MuensterGerman Center for Pediatric and Adolescent RheumatologyCentre for Paediatric Rheumatology, Department of Paediatrics, Asklepios Clinic Sankt AugustinCentre of Paediatric Rheumatology, Olga HospitalDepartment of Paediatric Respiratory Medicine, Immunology and Critical Care Medicine, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu BerlinAutoinflammation Reference Center Tübingen (Arct), Division of Paediatric Rheumatology, Department of Paediatrics, University Hospital TübingenDepartment of Pediatric and Adolescent Medicine, Kliniken Der Stadt Köln gGmbHUniversity of Duisburg-EssenPediatric Rheumatology, St. Josef-StiftDeutsches Rheumaforschungszentrum BerlinDepartment of Ophthalmology at St. Franziskus HospitalAbstract Background Juvenile idiopathic arthritis-associated uveitis (JIAU) typically takes a chronic course, frequently leading to ocular complications and often requiring long-term treatment. The present study assesses the 5-years outcome of JIAU by analyzing data from a prospective study initiated in 2010. Methods Data from 75 patients with onset of uveitis after study enrollment, and with a documentation at 5-years follow-up (5yFU) were available for analysis of uveitis characteristics, frequency and predictors of „inactivity on medication “ (defined as inactive uveitis for ≥ 6 months) and „inactivity off medication “ (defined as inactive uveitis for ≥ 6 months off medication). Results At the 5yFU, visual acuity remained good in the majority of eyes (LogMAR < 0.1 in 65.5%; mean LogMAR 0.11 ± 0.31), ocular surgery was required in only 5% of patients, although complications occurred in 46.7% of patients until the 5yFU. Uveitis was inactive in 85.3% of patients, with 77.3% still receiving disease-modifying antirheumatic drugs (DMARDs). Until 5yFU, 82.7% of patients experienced ≥ one episode of „inactivity on medication “ (30.7% once, 37.3% twice, 14.7% three or more times), and 17.3% ≥ one episode of „inactivity off medication “, respectively. Both „inactivity on medication “ as well as „inactivity off medication “ were associated with lower JIA disease activity (cJADAS10; ESR), and with an increased quality of life. Conclusions Despite intensified DMARD treatment, almost half of the children experience JIAU-related ocular complications after 5 years of disease; however, visual acuity mostly remains good. Uveitis inactivity can be achieved frequently, but is often limited in duration. Lower JIA activity appears to correlate with uveitis inactivity on and off medication.https://doi.org/10.1186/s13075-025-03531-wUveitisJuvenile idiopathic arthritisPrognosisBiological therapy |
| spellingShingle | Karoline Baquet-Walscheid Kirsten Minden Martina Niewerth Frank Dressler Ivan Foeldvari Dirk Foell Johannes-Peter Haas Gerd Horneff Anton Hospach Tilmann Kallinich Jasmin Kümmerle-Deschner Kirsten Mönkemöller Christoph Tappeiner Daniel Windschall Jens Klotsche Arnd Heiligenhaus Course of uveitis in children with juvenile idiopathic arthritis (JIA): Five years follow-up data from a prospective multicenter Inception Cohort of Newly diagnosed patients with JIA (ICON-JIA) study Arthritis Research & Therapy Uveitis Juvenile idiopathic arthritis Prognosis Biological therapy |
| title | Course of uveitis in children with juvenile idiopathic arthritis (JIA): Five years follow-up data from a prospective multicenter Inception Cohort of Newly diagnosed patients with JIA (ICON-JIA) study |
| title_full | Course of uveitis in children with juvenile idiopathic arthritis (JIA): Five years follow-up data from a prospective multicenter Inception Cohort of Newly diagnosed patients with JIA (ICON-JIA) study |
| title_fullStr | Course of uveitis in children with juvenile idiopathic arthritis (JIA): Five years follow-up data from a prospective multicenter Inception Cohort of Newly diagnosed patients with JIA (ICON-JIA) study |
| title_full_unstemmed | Course of uveitis in children with juvenile idiopathic arthritis (JIA): Five years follow-up data from a prospective multicenter Inception Cohort of Newly diagnosed patients with JIA (ICON-JIA) study |
| title_short | Course of uveitis in children with juvenile idiopathic arthritis (JIA): Five years follow-up data from a prospective multicenter Inception Cohort of Newly diagnosed patients with JIA (ICON-JIA) study |
| title_sort | course of uveitis in children with juvenile idiopathic arthritis jia five years follow up data from a prospective multicenter inception cohort of newly diagnosed patients with jia icon jia study |
| topic | Uveitis Juvenile idiopathic arthritis Prognosis Biological therapy |
| url | https://doi.org/10.1186/s13075-025-03531-w |
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