The presence of Mycoplasma pneumoniae infection and GM1 ganglioside antibodies in Guillain-Barré syndrome
Introduction: Guillain-Barré syndrome (GBS) is an autoimmune disorder affecting the peripheral nervous system, usually triggered by an acute infection. GBS patients are known to have antecedent bacterial infections associated with auto-antibodies to various gangliosides. This investigation aimed to...
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The Journal of Infection in Developing Countries
2011-03-01
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| Series: | Journal of Infection in Developing Countries |
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| Online Access: | https://jidc.org/index.php/journal/article/view/1508 |
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| author | Mridula B Sharma Rama Chaudhry Irum Tabassum Nishat Hussain Ahmed Jitendra Kumar Sahu Benu Dhawan Veena Kalra |
| author_facet | Mridula B Sharma Rama Chaudhry Irum Tabassum Nishat Hussain Ahmed Jitendra Kumar Sahu Benu Dhawan Veena Kalra |
| author_sort | Mridula B Sharma |
| collection | DOAJ |
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Introduction: Guillain-Barré syndrome (GBS) is an autoimmune disorder affecting the peripheral nervous system, usually triggered by an acute infection. GBS patients are known to have antecedent bacterial infections associated with auto-antibodies to various gangliosides. This investigation aimed to evaluate GBS patients for serological evidence of Mycoplasma pneumoniae infection and anti GM1 ganglioside antibodies.
Methodology: This cross-sectional study included 57 pediatric GBS patients, 42 neurological controls (i.e., non-GBS Acute Flaccid Paralysis cases) and 35 non-neurological controls. Enzyme linked immune sorbent assay (ELISA) was performed on the sera of the subjects to detect IgM and IgG antibodies against Mycoplasma (M.) pneumoniae and GM1 gangliosides.
Results: The results showed that 15.79% and 21.05% GBS patients were positive for IgG and IgM antibodies against M. pneumoniae as compared to 2.38% (P < 0.05) and 14.2% in non-GBS-AFP and 5.7% and 14.2% in non-neurological controls respectively. Additionally, 43.85% and 38.54% GBS patients were positive for IgG and IgM antibodies against GM1 gangliosides as compared to 38.09% and 28.57% in non-GBS-AFP and 14.2% and 2.84% in non-neurological controls respectively (P < 0.05).
Conclusions: Significant difference in levels of IgG antibodies against M. pneumoniae was observed between GBS patients and neurological controls, suggesting M. pneumoniae to be an important antecedent to GBS. Significant difference in levels of anti GM1 ganglioside antibodies (IgG & IgM) was seen between GBS patients and non-neurological controls, highlighting its possible role in the pathogenesis of GBS.
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| format | Article |
| id | doaj-art-4b03e08b292b4ab8a74add4541dfd758 |
| institution | OA Journals |
| issn | 1972-2680 |
| language | English |
| publishDate | 2011-03-01 |
| publisher | The Journal of Infection in Developing Countries |
| record_format | Article |
| series | Journal of Infection in Developing Countries |
| spelling | doaj-art-4b03e08b292b4ab8a74add4541dfd7582025-08-20T02:27:23ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802011-03-0150610.3855/jidc.1508The presence of Mycoplasma pneumoniae infection and GM1 ganglioside antibodies in Guillain-Barré syndromeMridula B Sharma0Rama Chaudhry1Irum Tabassum2Nishat Hussain Ahmed3Jitendra Kumar Sahu4Benu Dhawan5Veena Kalra6Department of Microbiology, All India Institute of Medical Sciences, New Delhi, IndiaDepartment of Microbiology, All India Institute of Medical Sciences, New Delhi, IndiaDepartment of Microbiology, All India Institute of Medical Sciences, New Delhi, IndiaDepartment of Microbiology, All India Institute of Medical Sciences, New Delhi, IndiaDepartment of Pediatrics, All India Institute of Medical Sciences, New Delhi, IndiaDepartment of Microbiology, All India Institute of Medical Sciences, New Delhi, IndiaDepartment of Pediatrics, All India Institute of Medical Sciences, New Delhi, India Introduction: Guillain-Barré syndrome (GBS) is an autoimmune disorder affecting the peripheral nervous system, usually triggered by an acute infection. GBS patients are known to have antecedent bacterial infections associated with auto-antibodies to various gangliosides. This investigation aimed to evaluate GBS patients for serological evidence of Mycoplasma pneumoniae infection and anti GM1 ganglioside antibodies. Methodology: This cross-sectional study included 57 pediatric GBS patients, 42 neurological controls (i.e., non-GBS Acute Flaccid Paralysis cases) and 35 non-neurological controls. Enzyme linked immune sorbent assay (ELISA) was performed on the sera of the subjects to detect IgM and IgG antibodies against Mycoplasma (M.) pneumoniae and GM1 gangliosides. Results: The results showed that 15.79% and 21.05% GBS patients were positive for IgG and IgM antibodies against M. pneumoniae as compared to 2.38% (P < 0.05) and 14.2% in non-GBS-AFP and 5.7% and 14.2% in non-neurological controls respectively. Additionally, 43.85% and 38.54% GBS patients were positive for IgG and IgM antibodies against GM1 gangliosides as compared to 38.09% and 28.57% in non-GBS-AFP and 14.2% and 2.84% in non-neurological controls respectively (P < 0.05). Conclusions: Significant difference in levels of IgG antibodies against M. pneumoniae was observed between GBS patients and neurological controls, suggesting M. pneumoniae to be an important antecedent to GBS. Significant difference in levels of anti GM1 ganglioside antibodies (IgG & IgM) was seen between GBS patients and non-neurological controls, highlighting its possible role in the pathogenesis of GBS. https://jidc.org/index.php/journal/article/view/1508GM1 GangliosidesGuillain-Barré syndromeMycoplasma pneumoniaeNon-GBS-acute flaccid paralysis |
| spellingShingle | Mridula B Sharma Rama Chaudhry Irum Tabassum Nishat Hussain Ahmed Jitendra Kumar Sahu Benu Dhawan Veena Kalra The presence of Mycoplasma pneumoniae infection and GM1 ganglioside antibodies in Guillain-Barré syndrome Journal of Infection in Developing Countries GM1 Gangliosides Guillain-Barré syndrome Mycoplasma pneumoniae Non-GBS-acute flaccid paralysis |
| title | The presence of Mycoplasma pneumoniae infection and GM1 ganglioside antibodies in Guillain-Barré syndrome |
| title_full | The presence of Mycoplasma pneumoniae infection and GM1 ganglioside antibodies in Guillain-Barré syndrome |
| title_fullStr | The presence of Mycoplasma pneumoniae infection and GM1 ganglioside antibodies in Guillain-Barré syndrome |
| title_full_unstemmed | The presence of Mycoplasma pneumoniae infection and GM1 ganglioside antibodies in Guillain-Barré syndrome |
| title_short | The presence of Mycoplasma pneumoniae infection and GM1 ganglioside antibodies in Guillain-Barré syndrome |
| title_sort | presence of mycoplasma pneumoniae infection and gm1 ganglioside antibodies in guillain barre syndrome |
| topic | GM1 Gangliosides Guillain-Barré syndrome Mycoplasma pneumoniae Non-GBS-acute flaccid paralysis |
| url | https://jidc.org/index.php/journal/article/view/1508 |
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