A prospective hospital-based study on C-reactive protein as a response predictor of antidepressant treatment in drug naïve patients with major depressive disorder
Background: C-reactive protein (CRP) is an acute phase reactant that is implicated in the pathogenesis of major depressive disorder (MDD), due to its role in the execution of various important neurological events, including neurogenesis, mediation of neural plasticity, and synaptic transmission. Aim...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-04-01
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| Series: | Indian Journal of Psychiatry |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/indianjpsychiatry.indianjpsychiatry_380_22 |
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| author | Didakamiwan Khonglah Arghya Pal Nitu Mallik Debes Ray Malay Ghosal Rudraprasad Acharya |
| author_facet | Didakamiwan Khonglah Arghya Pal Nitu Mallik Debes Ray Malay Ghosal Rudraprasad Acharya |
| author_sort | Didakamiwan Khonglah |
| collection | DOAJ |
| description | Background:
C-reactive protein (CRP) is an acute phase reactant that is implicated in the pathogenesis of major depressive disorder (MDD), due to its role in the execution of various important neurological events, including neurogenesis, mediation of neural plasticity, and synaptic transmission.
Aims:
This study was conducted to determine the relationship between the level of CRP to remission rates after antidepressant therapy.
Methods:
Fifty patients of first episode MDD with no past history of antidepressant exposure and other medical comorbidity were recruited after obtaining consent for Escitalopram therapy. The CRP levels of the patients were evaluated on the day of recruitment and depressive symptoms were monitored using Montgomery–Asberg Depression Rating Scale at weeks 0, 3, 6, and 12. The patients with low (≤10 mg/l) and high (>10 mg/l) CRP levels were compared for time taken to achieve remission using Kaplan–Meier survival analysis.
Results:
The Kaplan–Meier survival analysis showed a significantly higher proportion of patients with low CRP levels attained remission than patients with higher CRP levels (Log-rank = 7.594; dF = 1; P = 0.006). The age, compliance to pharmacotherapy, and disability did not significantly affect the remission rates of the patients.
Conclusion:
Our study confirms that higher levels of CRP can lead to poorer remission rates in patients with MDD after antidepressant therapy and can predict treatment resistance. |
| format | Article |
| id | doaj-art-4b02342f9eac46588302bfc606e65a40 |
| institution | Kabale University |
| issn | 0019-5545 1998-3794 |
| language | English |
| publishDate | 2023-04-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Psychiatry |
| spelling | doaj-art-4b02342f9eac46588302bfc606e65a402025-01-20T11:16:25ZengWolters Kluwer Medknow PublicationsIndian Journal of Psychiatry0019-55451998-37942023-04-0165447247610.4103/indianjpsychiatry.indianjpsychiatry_380_22A prospective hospital-based study on C-reactive protein as a response predictor of antidepressant treatment in drug naïve patients with major depressive disorderDidakamiwan KhonglahArghya PalNitu MallikDebes RayMalay GhosalRudraprasad AcharyaBackground: C-reactive protein (CRP) is an acute phase reactant that is implicated in the pathogenesis of major depressive disorder (MDD), due to its role in the execution of various important neurological events, including neurogenesis, mediation of neural plasticity, and synaptic transmission. Aims: This study was conducted to determine the relationship between the level of CRP to remission rates after antidepressant therapy. Methods: Fifty patients of first episode MDD with no past history of antidepressant exposure and other medical comorbidity were recruited after obtaining consent for Escitalopram therapy. The CRP levels of the patients were evaluated on the day of recruitment and depressive symptoms were monitored using Montgomery–Asberg Depression Rating Scale at weeks 0, 3, 6, and 12. The patients with low (≤10 mg/l) and high (>10 mg/l) CRP levels were compared for time taken to achieve remission using Kaplan–Meier survival analysis. Results: The Kaplan–Meier survival analysis showed a significantly higher proportion of patients with low CRP levels attained remission than patients with higher CRP levels (Log-rank = 7.594; dF = 1; P = 0.006). The age, compliance to pharmacotherapy, and disability did not significantly affect the remission rates of the patients. Conclusion: Our study confirms that higher levels of CRP can lead to poorer remission rates in patients with MDD after antidepressant therapy and can predict treatment resistance.https://journals.lww.com/10.4103/indianjpsychiatry.indianjpsychiatry_380_22c-reactive proteindrug naïveescitaloprammajor depressive disorderremission |
| spellingShingle | Didakamiwan Khonglah Arghya Pal Nitu Mallik Debes Ray Malay Ghosal Rudraprasad Acharya A prospective hospital-based study on C-reactive protein as a response predictor of antidepressant treatment in drug naïve patients with major depressive disorder Indian Journal of Psychiatry c-reactive protein drug naïve escitalopram major depressive disorder remission |
| title | A prospective hospital-based study on C-reactive protein as a response predictor of antidepressant treatment in drug naïve patients with major depressive disorder |
| title_full | A prospective hospital-based study on C-reactive protein as a response predictor of antidepressant treatment in drug naïve patients with major depressive disorder |
| title_fullStr | A prospective hospital-based study on C-reactive protein as a response predictor of antidepressant treatment in drug naïve patients with major depressive disorder |
| title_full_unstemmed | A prospective hospital-based study on C-reactive protein as a response predictor of antidepressant treatment in drug naïve patients with major depressive disorder |
| title_short | A prospective hospital-based study on C-reactive protein as a response predictor of antidepressant treatment in drug naïve patients with major depressive disorder |
| title_sort | prospective hospital based study on c reactive protein as a response predictor of antidepressant treatment in drug naive patients with major depressive disorder |
| topic | c-reactive protein drug naïve escitalopram major depressive disorder remission |
| url | https://journals.lww.com/10.4103/indianjpsychiatry.indianjpsychiatry_380_22 |
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