The tubulin polymerization inhibitor gambogenic acid induces myelodysplastic syndrome cell apoptosis through upregulation of Fas expression mediated by the NF-κB signaling pathway

The tubulin polymerization inhibitor gambogenic acid induces myelodysplastic syndrome cell apoptosis through upregulation of Fas expression mediated by the NF-κB signaling pathway

The development of an effective treatment for myelodysplastic syndrome (MDS) is needed due to the insufficient efficacy of current therapies. Gambogenic acid (GNA) is a xanthone constituent of gamboge, a resin secreted by Garcinia hanburyi Hook. f. GNA exhibits antitumor and apoptosis-inducing activ...

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Bibliographic Details
Main Authors: Cheng Zhong, Shijun Wang, Lei Xia, Xiaoman Yang, Liguang Fang, Xianyi Zhang, Mengyue Wang, Haijun Zhao, Guanghui Wang, Jinglong Wu, Ruijian Guo, Ming Zhong, Eiichi Gohda
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Cancer Biology & Therapy
Subjects:
Gambogenic acid
apoptosis
NF-κB
Fas
microtubule
G2/M arrest
Online Access:https://www.tandfonline.com/doi/10.1080/15384047.2024.2427374
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