Different features of influenza A H1N1pdm09 virus infection among adults in 2009/10 and 2010/11
Introduction: Influenza A H1N1pdm09 virus infection causes an epidemiologically and clinically severe disease mostly characterized by pneumonia, resulting in a high mortality rate. The purpose of this study was to investigate and compare epidemiological and clinical characteristics of influenza A H1...
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The Journal of Infection in Developing Countries
2016-02-01
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| Series: | Journal of Infection in Developing Countries |
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| Online Access: | https://jidc.org/index.php/journal/article/view/6040 |
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| author | Svjetlana Grgic Sinisa Skocibusic Elvira Celjuska-Tosev Jadranka Nikolic Jurica Arapovic Ilija Kuzman |
| author_facet | Svjetlana Grgic Sinisa Skocibusic Elvira Celjuska-Tosev Jadranka Nikolic Jurica Arapovic Ilija Kuzman |
| author_sort | Svjetlana Grgic |
| collection | DOAJ |
| description | Introduction: Influenza A H1N1pdm09 virus infection causes an epidemiologically and clinically severe disease mostly characterized by pneumonia, resulting in a high mortality rate. The purpose of this study was to investigate and compare epidemiological and clinical characteristics of influenza A H1N1pdm09 virus infection in patients hospitalized during the pandemic (2009/10) and post-pandemic seasons (2010/11).
Methodology: The data of patients with laboratory-confirmed influenza A H1N1pdm09 virus infection hospitalized and treated at the University Hospital for Infectious Diseases Dr. Fran Mihaljevic in Zagreb, Croatia in the first two seasons of appearance were analyzed.
Results: Compared to the pandemic season, in the post-pandemic season, patients were hospitalized longer, had higher values of inflammatory parameters, and were more often treated with antibiotics. The total number of risk factors in patients did not vary significantly between the two seasons. In the pandemic season, a significantly higher number of obese patients and patients with chronic lung disease was observed, whereas in the post-pandemic season, a statistically significant number of patients presented with symptoms of chronic cardiac and neuromuscular diseases. Primary viral pneumonia was frequently registered in younger adults during the pandemic season, whereas in the post-pandemic season, there were more cases of bacterial pneumonia.
Conclusions: During the pandemic season, the influenza A H1N1pdm09 virus infection caused a severe disease with rare bacterial complications, especially in adult patients. The common characteristics of the influenza A H1N1pdm09 virus were lost in the post-pandemic season, assuming the shape and characteristics of the seasonal influenza A virus.
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| format | Article |
| id | doaj-art-4aee89678d7e4b98b6f50ccb47b540f7 |
| institution | OA Journals |
| issn | 1972-2680 |
| language | English |
| publishDate | 2016-02-01 |
| publisher | The Journal of Infection in Developing Countries |
| record_format | Article |
| series | Journal of Infection in Developing Countries |
| spelling | doaj-art-4aee89678d7e4b98b6f50ccb47b540f72025-08-20T02:27:09ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802016-02-01100210.3855/jidc.6040Different features of influenza A H1N1pdm09 virus infection among adults in 2009/10 and 2010/11Svjetlana Grgic0Sinisa Skocibusic1Elvira Celjuska-Tosev2Jadranka Nikolic3Jurica Arapovic4Ilija Kuzman5University Hospital Mostar, Mostar, Bosnia and HerzegovinaUniversity Hospital Mostar, Mostar, Bosnia and HerzegovinaUniversity Hospital for Infectious Diseases Dr. Fran Mihaljevic, Zagreb, CroatiaUniversity Hospital Mostar, Mostar, Bosnia and HerzegovinaUniversity Hospital Mostar, Mostar, Bosnia and HerzegovinaUniversity of Mostar, Mostar, Bosnia and HerzegovinaIntroduction: Influenza A H1N1pdm09 virus infection causes an epidemiologically and clinically severe disease mostly characterized by pneumonia, resulting in a high mortality rate. The purpose of this study was to investigate and compare epidemiological and clinical characteristics of influenza A H1N1pdm09 virus infection in patients hospitalized during the pandemic (2009/10) and post-pandemic seasons (2010/11). Methodology: The data of patients with laboratory-confirmed influenza A H1N1pdm09 virus infection hospitalized and treated at the University Hospital for Infectious Diseases Dr. Fran Mihaljevic in Zagreb, Croatia in the first two seasons of appearance were analyzed. Results: Compared to the pandemic season, in the post-pandemic season, patients were hospitalized longer, had higher values of inflammatory parameters, and were more often treated with antibiotics. The total number of risk factors in patients did not vary significantly between the two seasons. In the pandemic season, a significantly higher number of obese patients and patients with chronic lung disease was observed, whereas in the post-pandemic season, a statistically significant number of patients presented with symptoms of chronic cardiac and neuromuscular diseases. Primary viral pneumonia was frequently registered in younger adults during the pandemic season, whereas in the post-pandemic season, there were more cases of bacterial pneumonia. Conclusions: During the pandemic season, the influenza A H1N1pdm09 virus infection caused a severe disease with rare bacterial complications, especially in adult patients. The common characteristics of the influenza A H1N1pdm09 virus were lost in the post-pandemic season, assuming the shape and characteristics of the seasonal influenza A virus. https://jidc.org/index.php/journal/article/view/6040influenza A virusH1N1 subtyperisk factorscomplicationsmortality |
| spellingShingle | Svjetlana Grgic Sinisa Skocibusic Elvira Celjuska-Tosev Jadranka Nikolic Jurica Arapovic Ilija Kuzman Different features of influenza A H1N1pdm09 virus infection among adults in 2009/10 and 2010/11 Journal of Infection in Developing Countries influenza A virus H1N1 subtype risk factors complications mortality |
| title | Different features of influenza A H1N1pdm09 virus infection among adults in 2009/10 and 2010/11 |
| title_full | Different features of influenza A H1N1pdm09 virus infection among adults in 2009/10 and 2010/11 |
| title_fullStr | Different features of influenza A H1N1pdm09 virus infection among adults in 2009/10 and 2010/11 |
| title_full_unstemmed | Different features of influenza A H1N1pdm09 virus infection among adults in 2009/10 and 2010/11 |
| title_short | Different features of influenza A H1N1pdm09 virus infection among adults in 2009/10 and 2010/11 |
| title_sort | different features of influenza a h1n1pdm09 virus infection among adults in 2009 10 and 2010 11 |
| topic | influenza A virus H1N1 subtype risk factors complications mortality |
| url | https://jidc.org/index.php/journal/article/view/6040 |
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