“Colon”ised by the unexpected: a case of extrauterine epithelioid trophoblastic tumour
Abstract Introduction Extrauterine epithelioid trophoblastic tumour is an exceedingly rare and aggressive form of gestational trophoblastic disease that arises outside the uterus and is characterised by the proliferation of intermediate trophoblastic cells. Unlike more common forms of gestational tr...
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| Format: | Article |
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BMC
2025-05-01
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| Series: | Diagnostic Pathology |
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| Online Access: | https://doi.org/10.1186/s13000-025-01617-2 |
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| author | Shalini Radhakrishnan Nischitha N. Suvarna Saraswathy Sreeram Srirama Bhat |
| author_facet | Shalini Radhakrishnan Nischitha N. Suvarna Saraswathy Sreeram Srirama Bhat |
| author_sort | Shalini Radhakrishnan |
| collection | DOAJ |
| description | Abstract Introduction Extrauterine epithelioid trophoblastic tumour is an exceedingly rare and aggressive form of gestational trophoblastic disease that arises outside the uterus and is characterised by the proliferation of intermediate trophoblastic cells. Unlike more common forms of gestational trophoblastic diseases, such as hydatidiform moles and choriocarcinoma, this entity presents unique diagnostic and therapeutic challenges due to its atypical location and clinical features. Thus far, no documented cases of this entity have been reported in the colon. Case presentation We report the case of a 42-year-old woman who presented with complaints of lower abdominal pain and a palpable mass in the left iliac fossa, initially suspected to be an ectopic pregnancy. On radiological evaluation, a provisional diagnosis of gastrointestinal stromal tumour was made, following which the patient underwent a left colectomy with resection and anastomosis, and the excised specimen on comprehensive histopathological and immunohistochemical analysis was diagnosed as a case of extrauterine epithelioid trophoblastic tumour. However, the patient’s condition deteriorated, and she succumbed to the disease one month after the diagnosis. Conclusion The rarity of extrauterine trophoblastic tumours contributes to limited clinical experience and treatment protocols, resulting in poor prognoses. This case report highlights the importance of histopathological examination for a confirmatory diagnosis, ensuring timely identification and improving patient outcomes. |
| format | Article |
| id | doaj-art-4ae8057e40d0422f925a40df9addbbf4 |
| institution | OA Journals |
| issn | 1746-1596 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Diagnostic Pathology |
| spelling | doaj-art-4ae8057e40d0422f925a40df9addbbf42025-08-20T01:52:26ZengBMCDiagnostic Pathology1746-15962025-05-012011610.1186/s13000-025-01617-2“Colon”ised by the unexpected: a case of extrauterine epithelioid trophoblastic tumourShalini Radhakrishnan0Nischitha N. Suvarna1Saraswathy Sreeram2Srirama Bhat3Department of Pathology, Kasturba Medical College, Mangalore, Manipal Academy of Higher EducationDepartment of Pathology, Kasturba Medical College, Mangalore, Manipal Academy of Higher EducationDepartment of Pathology, Kasturba Medical College, Mangalore, Manipal Academy of Higher EducationDepartment of General Surgery, Kasturba Medical College, Mangalore, Manipal Academy of Higher EducationAbstract Introduction Extrauterine epithelioid trophoblastic tumour is an exceedingly rare and aggressive form of gestational trophoblastic disease that arises outside the uterus and is characterised by the proliferation of intermediate trophoblastic cells. Unlike more common forms of gestational trophoblastic diseases, such as hydatidiform moles and choriocarcinoma, this entity presents unique diagnostic and therapeutic challenges due to its atypical location and clinical features. Thus far, no documented cases of this entity have been reported in the colon. Case presentation We report the case of a 42-year-old woman who presented with complaints of lower abdominal pain and a palpable mass in the left iliac fossa, initially suspected to be an ectopic pregnancy. On radiological evaluation, a provisional diagnosis of gastrointestinal stromal tumour was made, following which the patient underwent a left colectomy with resection and anastomosis, and the excised specimen on comprehensive histopathological and immunohistochemical analysis was diagnosed as a case of extrauterine epithelioid trophoblastic tumour. However, the patient’s condition deteriorated, and she succumbed to the disease one month after the diagnosis. Conclusion The rarity of extrauterine trophoblastic tumours contributes to limited clinical experience and treatment protocols, resulting in poor prognoses. This case report highlights the importance of histopathological examination for a confirmatory diagnosis, ensuring timely identification and improving patient outcomes.https://doi.org/10.1186/s13000-025-01617-2Epithelioid trophoblastic tumourGestational trophoblastic diseaseHuman chorionic gonadotrophinColonPathologyImmunohistochemistry |
| spellingShingle | Shalini Radhakrishnan Nischitha N. Suvarna Saraswathy Sreeram Srirama Bhat “Colon”ised by the unexpected: a case of extrauterine epithelioid trophoblastic tumour Diagnostic Pathology Epithelioid trophoblastic tumour Gestational trophoblastic disease Human chorionic gonadotrophin Colon Pathology Immunohistochemistry |
| title | “Colon”ised by the unexpected: a case of extrauterine epithelioid trophoblastic tumour |
| title_full | “Colon”ised by the unexpected: a case of extrauterine epithelioid trophoblastic tumour |
| title_fullStr | “Colon”ised by the unexpected: a case of extrauterine epithelioid trophoblastic tumour |
| title_full_unstemmed | “Colon”ised by the unexpected: a case of extrauterine epithelioid trophoblastic tumour |
| title_short | “Colon”ised by the unexpected: a case of extrauterine epithelioid trophoblastic tumour |
| title_sort | colon ised by the unexpected a case of extrauterine epithelioid trophoblastic tumour |
| topic | Epithelioid trophoblastic tumour Gestational trophoblastic disease Human chorionic gonadotrophin Colon Pathology Immunohistochemistry |
| url | https://doi.org/10.1186/s13000-025-01617-2 |
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