PU.1 dictates β-amyloid-induced TREM2 expression upregulation in microglia in a transgenic model of Alzheimer’s disease

PU.1 dictates β-amyloid-induced TREM2 expression upregulation in microglia in a transgenic model of Alzheimer’s disease

IntroductionMicroglial dysfunction is characteristic of Alzheimer’s disease (AD), with triggering receptor expressed on myeloid cells 2 (TREM2) and transcription factor PU.1 playing crucial roles. However, the relationship between TREM2 and PU.1 remains unclear.MethodsWe investigated TREM2 and PU.1...

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Bibliographic Details
Main Authors: Zhen Wei, Xiaodong Pan, Xiaoli Cui, Jing Zhang, Xiaoman Dai, Yuqi Zeng, Xiaochun Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Aging Neuroscience
Subjects:
TREM2
PU.1/Spi1
β-amyloid
microglia
Alzheimer’s disease
5 × FAD
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2025.1537388/full
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