Astrocytic GLUT1 deletion in adult mice enhances glucose metabolism and resilience to stroke

Astrocytic GLUT1 deletion in adult mice enhances glucose metabolism and resilience to stroke

Abstract Brain activity relies on a steady supply of blood glucose. Astrocytes express glucose transporter 1 (GLUT1), considered their primary route for glucose uptake to sustain metabolic and antioxidant support for neurons. While GLUT1 deficiency causes severe developmental impairments, its role i...

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Main Authors: Laetitia Thieren, Henri S. Zanker, Jeanne Droux, Urvashi Dalvi, Matthias T. Wyss, Rebecca Waag, Pierre-Luc Germain, Lukas M. von Ziegler, Zoe J. Looser, Ladina Hösli, Luca Ravotto, E. Dale Abel, Johannes Bohacek, Susanne Wegener, L. Felipe Barros, Mohamad El Amki, Bruno Weber, Aiman S. Saab
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-59400-2
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