Programmed cell death signatures-driven microglial transformation in Alzheimer’s disease: single-cell transcriptomics and functional validation

Programmed cell death signatures-driven microglial transformation in Alzheimer’s disease: single-cell transcriptomics and functional validation

BackgroundThis study aims to develop and validate a programmed cell death signature (PCDS) for predicting and classifying Alzheimer’s disease (AD) using an integrated machine learning framework. We further explore the role of S100A4 in AD pathogenesis, particularly in microglia.MethodsA total of one...

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Bibliographic Details
Main Authors: Mi-Mi Li, Ying-Xia Yang, Ya-Li Huang, Shu-Juan Wu, Wan-Li Huang, Li-Chao Ye, Ying-Ying Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
Alzheimer’s disease
programmed cell death
microglia
single-cell
machine learning
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1610717/full
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