Targeting m<sup>6</sup>A RNA Modification in Tumor Therapeutics
The prevalent eukaryotic RNA modification N6-methyladenosine (m<sup>6</sup>A), which is distributed in more than 50% of cases, has demonstrated significant implications in both normal development and disease progression, particularly in the context of cancer. This review aims to discuss...
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MDPI AG
2025-03-01
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| Series: | Current Oncology |
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| Online Access: | https://www.mdpi.com/1718-7729/32/3/159 |
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| author | Zhenwei Mao Min Li Shengjun Wang |
| author_facet | Zhenwei Mao Min Li Shengjun Wang |
| author_sort | Zhenwei Mao |
| collection | DOAJ |
| description | The prevalent eukaryotic RNA modification N6-methyladenosine (m<sup>6</sup>A), which is distributed in more than 50% of cases, has demonstrated significant implications in both normal development and disease progression, particularly in the context of cancer. This review aims to discuss the potential efficacy of targeting tumor cells through modulation of m<sup>6</sup>A RNA levels. Specifically, we discuss how the upregulation or downregulation of integral or specific targets is effective in treating different tumor types and patients. Additionally, we will cover the factors influencing the efficacy of m<sup>6</sup>A RNA targeting in tumor treatment. Our review will focus on the impact of targeting m<sup>6</sup>A mRNA on genes and cells and assess its potential as a therapeutic strategy for tumors. Despite the challenges involved, further research on m<sup>6</sup>A RNA in tumors and its integration with existing tumor therapy approaches is warranted. |
| format | Article |
| id | doaj-art-4adb0f532e1f4924bb80113c05f09fb8 |
| institution | OA Journals |
| issn | 1198-0052 1718-7729 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Oncology |
| spelling | doaj-art-4adb0f532e1f4924bb80113c05f09fb82025-08-20T02:11:25ZengMDPI AGCurrent Oncology1198-00521718-77292025-03-0132315910.3390/curroncol32030159Targeting m<sup>6</sup>A RNA Modification in Tumor TherapeuticsZhenwei Mao0Min Li1Shengjun Wang2Department of Laboratory Medicine, Affiliated People’s Hospital, Jiangsu University, Zhenjiang 212002, ChinaDepartment of Laboratory Medicine, Affiliated People’s Hospital, Jiangsu University, Zhenjiang 212002, ChinaJiangsu Key Laboratory of Laboratory Medicine, Department of Immunology, School of Medicine, Jiangsu University, Zhenjiang 212002, ChinaThe prevalent eukaryotic RNA modification N6-methyladenosine (m<sup>6</sup>A), which is distributed in more than 50% of cases, has demonstrated significant implications in both normal development and disease progression, particularly in the context of cancer. This review aims to discuss the potential efficacy of targeting tumor cells through modulation of m<sup>6</sup>A RNA levels. Specifically, we discuss how the upregulation or downregulation of integral or specific targets is effective in treating different tumor types and patients. Additionally, we will cover the factors influencing the efficacy of m<sup>6</sup>A RNA targeting in tumor treatment. Our review will focus on the impact of targeting m<sup>6</sup>A mRNA on genes and cells and assess its potential as a therapeutic strategy for tumors. Despite the challenges involved, further research on m<sup>6</sup>A RNA in tumors and its integration with existing tumor therapy approaches is warranted.https://www.mdpi.com/1718-7729/32/3/159N6-methyladenosine (m<sup>6</sup>A)mRNAtumortargeting therapy |
| spellingShingle | Zhenwei Mao Min Li Shengjun Wang Targeting m<sup>6</sup>A RNA Modification in Tumor Therapeutics Current Oncology N6-methyladenosine (m<sup>6</sup>A) mRNA tumor targeting therapy |
| title | Targeting m<sup>6</sup>A RNA Modification in Tumor Therapeutics |
| title_full | Targeting m<sup>6</sup>A RNA Modification in Tumor Therapeutics |
| title_fullStr | Targeting m<sup>6</sup>A RNA Modification in Tumor Therapeutics |
| title_full_unstemmed | Targeting m<sup>6</sup>A RNA Modification in Tumor Therapeutics |
| title_short | Targeting m<sup>6</sup>A RNA Modification in Tumor Therapeutics |
| title_sort | targeting m sup 6 sup a rna modification in tumor therapeutics |
| topic | N6-methyladenosine (m<sup>6</sup>A) mRNA tumor targeting therapy |
| url | https://www.mdpi.com/1718-7729/32/3/159 |
| work_keys_str_mv | AT zhenweimao targetingmsup6suparnamodificationintumortherapeutics AT minli targetingmsup6suparnamodificationintumortherapeutics AT shengjunwang targetingmsup6suparnamodificationintumortherapeutics |