Right inferior frontal cortex and preSMA in response inhibition: An investigation based on PTC model
Response inhibition is an essential component of cognitive function. A large body of literature has used neuroimaging data to uncover the neural architecture that regulates inhibitory control in general and movement cancelation. The presupplementary motor area (preSMA) and the right inferior frontal...
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Elsevier
2025-02-01
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| Series: | NeuroImage |
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| author | Lili Wu Mengjie Jiang Min Zhao Xin Hu Jing Wang Kaihua Zhang Ke Jia Fuxin Ren Fei Gao |
| author_facet | Lili Wu Mengjie Jiang Min Zhao Xin Hu Jing Wang Kaihua Zhang Ke Jia Fuxin Ren Fei Gao |
| author_sort | Lili Wu |
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| description | Response inhibition is an essential component of cognitive function. A large body of literature has used neuroimaging data to uncover the neural architecture that regulates inhibitory control in general and movement cancelation. The presupplementary motor area (preSMA) and the right inferior frontal cortex (rIFC) are the key nodes in the inhibitory control network. However, how these two regions contribute to response inhibition remains controversial. Based on the Pause-then-Cancel Model (PTC), this study employed functional magnetic resonance imaging (fMRI) to investigate the functional specificity of two regions in the stopping process. The Go/No-Go task (GNGT) and the Stop Signal Task (SST) were administered to the same group of participants. We used the GNGT to dissociate the pause process and both the GNGT and the SST to investigate the inhibition mechanism. Imaging data revealed that response inhibition produced by both tasks activated the preSMA and rIFC. Furthermore, an across-participants analysis showed that increased activation in the rIFC was associated with a delay in the go response in the GNGT. In contrast, increased activation in the preSMA was associated with good inhibition efficiency via the striatum in both GNGT and SST. These behavioral and imaging findings support the PTC model of the role of rIFC and preSMA, that the former is involved in a pause process to delay motor responses, whereas the preSMA is involved in the stopping of motor responses. |
| format | Article |
| id | doaj-art-4ad86bf7b79b450ebd3ff8d29d0db9f2 |
| institution | Kabale University |
| issn | 1095-9572 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage |
| spelling | doaj-art-4ad86bf7b79b450ebd3ff8d29d0db9f22025-01-23T05:26:21ZengElsevierNeuroImage1095-95722025-02-01306121004Right inferior frontal cortex and preSMA in response inhibition: An investigation based on PTC modelLili Wu0Mengjie Jiang1Min Zhao2Xin Hu3Jing Wang4Kaihua Zhang5Ke Jia6Fuxin Ren7Fei Gao8Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China; Department of Psychology, University of Chinese Academy of Sciences, Beijing, ChinaKey Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China; Department of Psychology, University of Chinese Academy of Sciences, Beijing, ChinaDepartment of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, ChinaDepartment of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, ChinaDepartment of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, ChinaSchool of Psychology, Shandong Normal University, Jinan, ChinaDepartment of Neurobiology, Affiliated Mental Health Center & Hangzhou Seventh People's Hospital, Zhejiang University School of Medicine, Hangzhou, China; Liangzhu Laboratory, MOE Frontier Science Center for Brain Science and Brain-machine Integration, State Key Laboratory of Brain-machine Intelligence, Zhejiang University, Hangzhou, China; NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University, Hangzhou, ChinaDepartment of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China; Corresponding author.Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China; Corresponding author.Response inhibition is an essential component of cognitive function. A large body of literature has used neuroimaging data to uncover the neural architecture that regulates inhibitory control in general and movement cancelation. The presupplementary motor area (preSMA) and the right inferior frontal cortex (rIFC) are the key nodes in the inhibitory control network. However, how these two regions contribute to response inhibition remains controversial. Based on the Pause-then-Cancel Model (PTC), this study employed functional magnetic resonance imaging (fMRI) to investigate the functional specificity of two regions in the stopping process. The Go/No-Go task (GNGT) and the Stop Signal Task (SST) were administered to the same group of participants. We used the GNGT to dissociate the pause process and both the GNGT and the SST to investigate the inhibition mechanism. Imaging data revealed that response inhibition produced by both tasks activated the preSMA and rIFC. Furthermore, an across-participants analysis showed that increased activation in the rIFC was associated with a delay in the go response in the GNGT. In contrast, increased activation in the preSMA was associated with good inhibition efficiency via the striatum in both GNGT and SST. These behavioral and imaging findings support the PTC model of the role of rIFC and preSMA, that the former is involved in a pause process to delay motor responses, whereas the preSMA is involved in the stopping of motor responses.http://www.sciencedirect.com/science/article/pii/S1053811925000047Response inhibitionA pause-then-cancel (PTC) modelPresupplementary motor area (preSMA)Right inferior frontal cortex (rIFC)Functional magnetic resonance imaging (fMRI) |
| spellingShingle | Lili Wu Mengjie Jiang Min Zhao Xin Hu Jing Wang Kaihua Zhang Ke Jia Fuxin Ren Fei Gao Right inferior frontal cortex and preSMA in response inhibition: An investigation based on PTC model NeuroImage Response inhibition A pause-then-cancel (PTC) model Presupplementary motor area (preSMA) Right inferior frontal cortex (rIFC) Functional magnetic resonance imaging (fMRI) |
| title | Right inferior frontal cortex and preSMA in response inhibition: An investigation based on PTC model |
| title_full | Right inferior frontal cortex and preSMA in response inhibition: An investigation based on PTC model |
| title_fullStr | Right inferior frontal cortex and preSMA in response inhibition: An investigation based on PTC model |
| title_full_unstemmed | Right inferior frontal cortex and preSMA in response inhibition: An investigation based on PTC model |
| title_short | Right inferior frontal cortex and preSMA in response inhibition: An investigation based on PTC model |
| title_sort | right inferior frontal cortex and presma in response inhibition an investigation based on ptc model |
| topic | Response inhibition A pause-then-cancel (PTC) model Presupplementary motor area (preSMA) Right inferior frontal cortex (rIFC) Functional magnetic resonance imaging (fMRI) |
| url | http://www.sciencedirect.com/science/article/pii/S1053811925000047 |
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