MYD88‐mutated Lymphoplasmacytic Lymphoma With Monoclonal Immunoglobulin G: A Case Report
ABSTRACT Lymphoplasmacytic lymphomas (LPL) are usually associated with serum monoclonal immunoglobulin M (IgM). Nevertheless, in some cases, these cells may secrete IgA or IgG monoclonal proteins or remain non‐secretory. We report a case from a patient with LPL‐secreting IgG who developed anaemia an...
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| Format: | Article |
| Language: | English |
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Wiley
2025-04-01
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| Series: | eJHaem |
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| Online Access: | https://doi.org/10.1002/jha2.70027 |
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| author | Morten Yung Isaksen Olav Karsten Vintermyr Håkon Reikvam |
| author_facet | Morten Yung Isaksen Olav Karsten Vintermyr Håkon Reikvam |
| author_sort | Morten Yung Isaksen |
| collection | DOAJ |
| description | ABSTRACT Lymphoplasmacytic lymphomas (LPL) are usually associated with serum monoclonal immunoglobulin M (IgM). Nevertheless, in some cases, these cells may secrete IgA or IgG monoclonal proteins or remain non‐secretory. We report a case from a patient with LPL‐secreting IgG who developed anaemia and splenomegaly during the disease course that necessitated treatment with bortezomib, dexamethasone, and rituximab. The case illustrates the need for clinicians and pathologists to consider LPLs as a differential diagnosis also without a serum monoclonal IgM. Clinical Trial Registration: The authors have confirmed clinical trial registration is not needed for this submission. |
| format | Article |
| id | doaj-art-4ad73edcede04a3db5ec710b4d514f9b |
| institution | OA Journals |
| issn | 2688-6146 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | eJHaem |
| spelling | doaj-art-4ad73edcede04a3db5ec710b4d514f9b2025-08-20T02:18:28ZengWileyeJHaem2688-61462025-04-0162n/an/a10.1002/jha2.70027MYD88‐mutated Lymphoplasmacytic Lymphoma With Monoclonal Immunoglobulin G: A Case ReportMorten Yung Isaksen0Olav Karsten Vintermyr1Håkon Reikvam2Department of Medicine Haukeland University Hospital Bergen NorwayDepartment of Pathology Haukeland University Hospital Bergen NorwayDepartment of Medicine Haukeland University Hospital Bergen NorwayABSTRACT Lymphoplasmacytic lymphomas (LPL) are usually associated with serum monoclonal immunoglobulin M (IgM). Nevertheless, in some cases, these cells may secrete IgA or IgG monoclonal proteins or remain non‐secretory. We report a case from a patient with LPL‐secreting IgG who developed anaemia and splenomegaly during the disease course that necessitated treatment with bortezomib, dexamethasone, and rituximab. The case illustrates the need for clinicians and pathologists to consider LPLs as a differential diagnosis also without a serum monoclonal IgM. Clinical Trial Registration: The authors have confirmed clinical trial registration is not needed for this submission.https://doi.org/10.1002/jha2.70027anaemia | case report | lymphoplasmacytic lymphoma | monoclonal IgG | MYD88 mutation |
| spellingShingle | Morten Yung Isaksen Olav Karsten Vintermyr Håkon Reikvam MYD88‐mutated Lymphoplasmacytic Lymphoma With Monoclonal Immunoglobulin G: A Case Report eJHaem anaemia | case report | lymphoplasmacytic lymphoma | monoclonal IgG | MYD88 mutation |
| title | MYD88‐mutated Lymphoplasmacytic Lymphoma With Monoclonal Immunoglobulin G: A Case Report |
| title_full | MYD88‐mutated Lymphoplasmacytic Lymphoma With Monoclonal Immunoglobulin G: A Case Report |
| title_fullStr | MYD88‐mutated Lymphoplasmacytic Lymphoma With Monoclonal Immunoglobulin G: A Case Report |
| title_full_unstemmed | MYD88‐mutated Lymphoplasmacytic Lymphoma With Monoclonal Immunoglobulin G: A Case Report |
| title_short | MYD88‐mutated Lymphoplasmacytic Lymphoma With Monoclonal Immunoglobulin G: A Case Report |
| title_sort | myd88 mutated lymphoplasmacytic lymphoma with monoclonal immunoglobulin g a case report |
| topic | anaemia | case report | lymphoplasmacytic lymphoma | monoclonal IgG | MYD88 mutation |
| url | https://doi.org/10.1002/jha2.70027 |
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