Advancing FIRES Treatment: The Potential of Intrathecal Dexamethasone
ABSTRACT Background Febrile infection‐related epilepsy syndrome (FIRES) is a rare, devastating epilepsy syndrome characterized by refractory status epilepticus following a febrile illness. Patient Description We describe a 12‐year‐old girl with FIRES who exhibited a remarkable clinical and electrogr...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-06-01
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| Series: | Annals of the Child Neurology Society |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/cns3.70008 |
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| Summary: | ABSTRACT Background Febrile infection‐related epilepsy syndrome (FIRES) is a rare, devastating epilepsy syndrome characterized by refractory status epilepticus following a febrile illness. Patient Description We describe a 12‐year‐old girl with FIRES who exhibited a remarkable clinical and electrographic response to intrathecal dexamethasone (IT‐DEX) after failing multiple antiseizure and immunomodulatory therapies. Despite persistent neuroinflammation, IT‐DEX led to rapid seizure control and significant neurological recovery. Conclusion This report supports IT‐DEX as a promising intervention in FIRES and underscores the need for further research into its mechanisms and long‐term efficacy. |
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| ISSN: | 2831-3267 |