Quercetin as a radiosensitizer for enhanced efficacy of radiotherapy in MCF-7 breast cancer cells
Introduction: Radiation therapy is a primary approach for treating cancer. Utilizing natural radiosensitizer compounds is crucial to enhance radiosensitivity in tumor tissue while minimizing damage to normal tissue. This study aims to assess the impact of quercetin as a radiosensitizing compound in...
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| Format: | Article |
| Language: | English |
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Zabansaraye Parsian Novin Mehr Institute
2024-12-01
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| Series: | Journal of Current Oncology and Medical Sciences |
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| Online Access: | https://submission.journalofcoms.com/index.php/JCOMS/article/view/262 |
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| author | Mohammad Banparvar Hamid Saeidi Saedi Mona Haddad Zahmatkesh |
| author_facet | Mohammad Banparvar Hamid Saeidi Saedi Mona Haddad Zahmatkesh |
| author_sort | Mohammad Banparvar |
| collection | DOAJ |
| description | Introduction: Radiation therapy is a primary approach for treating cancer. Utilizing natural radiosensitizer compounds is crucial to enhance radiosensitivity in tumor tissue while minimizing damage to normal tissue. This study aims to assess the impact of quercetin as a radiosensitizing compound in MCF-7 cells.
Materials and Methods: This research examined the impact of quercetin at concentrations of 20, 40, and 60 μM with and without radiation (2 and 3 Gy) on the MCF-7 breast cancer cell line as a radiosensitizer agent. The investigation employed a micronucleus test, clonogenic assay, and assessments of Superoxide-dismutase and catalase activity.
Results: The findings indicated that the group exposed to radiation exhibited a significant decrease in the number of colonies (P < 0.0001) and activity of SOD and CAT enzymes while showing a significant increase in the number of micronuclei compared to the control group (P < 0.0001). Additionally, in all the groups treated with quercetin and exposed to radiation, there was a notable increase in micronuclei and a significant decrease in the number of colonies and activity of CAT and SOD enzymes.
Conclusions: The study's findings demonstrated that quercetin has the ability to increase the sensitivity of MCF-7 breast cancer cells to ionizing radiation in a manner that depends on the dosage. |
| format | Article |
| id | doaj-art-4ad49e592e724ec5a09355b5446d418f |
| institution | Kabale University |
| issn | 2783-3127 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Zabansaraye Parsian Novin Mehr Institute |
| record_format | Article |
| series | Journal of Current Oncology and Medical Sciences |
| spelling | doaj-art-4ad49e592e724ec5a09355b5446d418f2025-01-15T06:26:55ZengZabansaraye Parsian Novin Mehr InstituteJournal of Current Oncology and Medical Sciences2783-31272024-12-0144925935Quercetin as a radiosensitizer for enhanced efficacy of radiotherapy in MCF-7 breast cancer cellsMohammad Banparvar0Hamid Saeidi Saedi1Mona Haddad Zahmatkesh2Student Research Committee, School of Pharmacy, Guilan University of Medical Sciences, Rasht, IranDepartment of Radiation Oncology, GI Cancer Screening and Prevention Research Center, School of Medicine, Guilan University of Medical Sciences, Rasht, IranDepartment of Pharmaceutical Biotechnology and Nuclear Pharmacy, School of Pharmacy, Guilan University of Medical Sciences, Rasht, IranIntroduction: Radiation therapy is a primary approach for treating cancer. Utilizing natural radiosensitizer compounds is crucial to enhance radiosensitivity in tumor tissue while minimizing damage to normal tissue. This study aims to assess the impact of quercetin as a radiosensitizing compound in MCF-7 cells. Materials and Methods: This research examined the impact of quercetin at concentrations of 20, 40, and 60 μM with and without radiation (2 and 3 Gy) on the MCF-7 breast cancer cell line as a radiosensitizer agent. The investigation employed a micronucleus test, clonogenic assay, and assessments of Superoxide-dismutase and catalase activity. Results: The findings indicated that the group exposed to radiation exhibited a significant decrease in the number of colonies (P < 0.0001) and activity of SOD and CAT enzymes while showing a significant increase in the number of micronuclei compared to the control group (P < 0.0001). Additionally, in all the groups treated with quercetin and exposed to radiation, there was a notable increase in micronuclei and a significant decrease in the number of colonies and activity of CAT and SOD enzymes. Conclusions: The study's findings demonstrated that quercetin has the ability to increase the sensitivity of MCF-7 breast cancer cells to ionizing radiation in a manner that depends on the dosage.https://submission.journalofcoms.com/index.php/JCOMS/article/view/262breast cancermcf-7radiosensitizingradiotherapy |
| spellingShingle | Mohammad Banparvar Hamid Saeidi Saedi Mona Haddad Zahmatkesh Quercetin as a radiosensitizer for enhanced efficacy of radiotherapy in MCF-7 breast cancer cells Journal of Current Oncology and Medical Sciences breast cancer mcf-7 radiosensitizing radiotherapy |
| title | Quercetin as a radiosensitizer for enhanced efficacy of radiotherapy in MCF-7 breast cancer cells |
| title_full | Quercetin as a radiosensitizer for enhanced efficacy of radiotherapy in MCF-7 breast cancer cells |
| title_fullStr | Quercetin as a radiosensitizer for enhanced efficacy of radiotherapy in MCF-7 breast cancer cells |
| title_full_unstemmed | Quercetin as a radiosensitizer for enhanced efficacy of radiotherapy in MCF-7 breast cancer cells |
| title_short | Quercetin as a radiosensitizer for enhanced efficacy of radiotherapy in MCF-7 breast cancer cells |
| title_sort | quercetin as a radiosensitizer for enhanced efficacy of radiotherapy in mcf 7 breast cancer cells |
| topic | breast cancer mcf-7 radiosensitizing radiotherapy |
| url | https://submission.journalofcoms.com/index.php/JCOMS/article/view/262 |
| work_keys_str_mv | AT mohammadbanparvar quercetinasaradiosensitizerforenhancedefficacyofradiotherapyinmcf7breastcancercells AT hamidsaeidisaedi quercetinasaradiosensitizerforenhancedefficacyofradiotherapyinmcf7breastcancercells AT monahaddadzahmatkesh quercetinasaradiosensitizerforenhancedefficacyofradiotherapyinmcf7breastcancercells |