Normothermic human kidney preservation drives iron accumulation and ferroptosis

Normothermic human kidney preservation drives iron accumulation and ferroptosis

Abstract Ex vivo normothermic machine perfusion has been proposed to protect deceased donor kidneys. However, its benefits remain ambiguous. We postulate that the use of red blood cells (RBCs) and associated secondary hemolysis may in fact cause renal injury, offsetting potential advantages. During...

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Bibliographic Details
Main Authors: Marlon J. A. de Haan, Marleen E. Jacobs, Annemarie M. A. de Graaf, Roan H. van Scheppingen, Rico J. E. Derks, Dorottya K. de Vries, Jesper Kers, Ian P. J. Alwayn, Cees van Kooten, Elena Sánchez-López, Martin Giera, Marten A. Engelse, Ton J. Rabelink
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-61058-9
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