Therapeutic effects of CTLA4Ig-overexpressing mesenchymal stem cell-derived extracellular vesicles in a mouse model of rheumatoid arthritis

Therapeutic effects of CTLA4Ig-overexpressing mesenchymal stem cell-derived extracellular vesicles in a mouse model of rheumatoid arthritis

Abstract Background Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by cartilage damage and bone erosion. Current pharmacological treatments often fail to repair damaged tissues and may cause severe immune-related side effects. Moreover, some patients exhibit inadequate respo...

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Bibliographic Details
Main Authors: Eun Wha Choi, I-Rang Lim, Ji Hong Park, Jiwoo Song, Bongkum Choi, Sungjoo Kim
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Stem Cell Research & Therapy
Subjects:
Autoimmune diseases
CTLA4Ig
Collagen-induced arthritis
Extracellular vesicles
Mesenchymal stem cell
Rheumatoid arthritis
Online Access:https://doi.org/10.1186/s13287-025-04524-x
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