THERAPY-RELATED MYELOID NEOPLASMS IN PATIENTS TREATED FOR HODGKIN LYMPHOMA
Hodgkin lymphoma (HL) is a malignancy of the lymphatic system with an incidence of 2-3/100.000/year in developed countries. With modern multi-agent chemotherapy protocols optionally combined with radiotherapy (RT), 80% to 90% of HL patients achieve long-term remission and can be considered cured. Ho...
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2011-10-01
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| Series: | Mediterranean Journal of Hematology and Infectious Diseases |
| Online Access: | http://www.mjhid.org/index.php/mjhid/article/view/290 |
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| author | Dennis A Eichenauer Andreas Engert |
| author_facet | Dennis A Eichenauer Andreas Engert |
| author_sort | Dennis A Eichenauer |
| collection | DOAJ |
| description | Hodgkin lymphoma (HL) is a malignancy of the lymphatic system with an incidence of 2-3/100.000/year in developed countries. With modern multi-agent chemotherapy protocols optionally combined with radiotherapy (RT), 80% to 90% of HL patients achieve long-term remission and can be considered cured. However, current standard approaches bear a considerable risk for the development of treatment-related late effects. Thus, one major focus of current clinical research in HL is reducing the incidence of these late effects that include heart failure, infertility, chronic fatigue and secondary malignancies such as secondary myelodysplastic syndrome and acute myeloid leukemia (secondary MDS/AML). In previous analyses, secondary MDS/AML after treatment for HL was associated with a poor prognosis. Nearly all patients died rapidly after diagnosis. However, more recent analyses indicated an improved outcome among patients with secondary MDS/AML who are eligible for modern anti-leukemic treatment and allogeneic stem cell transplantation (aSCT). This article gives an overview of recent reports on the incidence and the treatment of secondary MDS/AML after HL treatment and describes the efforts currently made to reduce the risk to develop this severe late effect. |
| format | Article |
| id | doaj-art-4ac7d0bfadc446068d1719dd662f78f0 |
| institution | Kabale University |
| issn | 2035-3006 |
| language | English |
| publishDate | 2011-10-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Mediterranean Journal of Hematology and Infectious Diseases |
| spelling | doaj-art-4ac7d0bfadc446068d1719dd662f78f02025-01-02T11:11:23ZengPAGEPress PublicationsMediterranean Journal of Hematology and Infectious Diseases2035-30062011-10-0131e2011046e201104610.4084/mjhid.2011.046182THERAPY-RELATED MYELOID NEOPLASMS IN PATIENTS TREATED FOR HODGKIN LYMPHOMADennis A Eichenauer0Andreas Engert1First Department of Internal Medicine University Hospital of Cologne D-50937 CologneFirst Department of Internal Medicine University Hospital of Cologne D-50937 CologneHodgkin lymphoma (HL) is a malignancy of the lymphatic system with an incidence of 2-3/100.000/year in developed countries. With modern multi-agent chemotherapy protocols optionally combined with radiotherapy (RT), 80% to 90% of HL patients achieve long-term remission and can be considered cured. However, current standard approaches bear a considerable risk for the development of treatment-related late effects. Thus, one major focus of current clinical research in HL is reducing the incidence of these late effects that include heart failure, infertility, chronic fatigue and secondary malignancies such as secondary myelodysplastic syndrome and acute myeloid leukemia (secondary MDS/AML). In previous analyses, secondary MDS/AML after treatment for HL was associated with a poor prognosis. Nearly all patients died rapidly after diagnosis. However, more recent analyses indicated an improved outcome among patients with secondary MDS/AML who are eligible for modern anti-leukemic treatment and allogeneic stem cell transplantation (aSCT). This article gives an overview of recent reports on the incidence and the treatment of secondary MDS/AML after HL treatment and describes the efforts currently made to reduce the risk to develop this severe late effect.http://www.mjhid.org/index.php/mjhid/article/view/290 |
| spellingShingle | Dennis A Eichenauer Andreas Engert THERAPY-RELATED MYELOID NEOPLASMS IN PATIENTS TREATED FOR HODGKIN LYMPHOMA Mediterranean Journal of Hematology and Infectious Diseases |
| title | THERAPY-RELATED MYELOID NEOPLASMS IN PATIENTS TREATED FOR HODGKIN LYMPHOMA |
| title_full | THERAPY-RELATED MYELOID NEOPLASMS IN PATIENTS TREATED FOR HODGKIN LYMPHOMA |
| title_fullStr | THERAPY-RELATED MYELOID NEOPLASMS IN PATIENTS TREATED FOR HODGKIN LYMPHOMA |
| title_full_unstemmed | THERAPY-RELATED MYELOID NEOPLASMS IN PATIENTS TREATED FOR HODGKIN LYMPHOMA |
| title_short | THERAPY-RELATED MYELOID NEOPLASMS IN PATIENTS TREATED FOR HODGKIN LYMPHOMA |
| title_sort | therapy related myeloid neoplasms in patients treated for hodgkin lymphoma |
| url | http://www.mjhid.org/index.php/mjhid/article/view/290 |
| work_keys_str_mv | AT dennisaeichenauer therapyrelatedmyeloidneoplasmsinpatientstreatedforhodgkinlymphoma AT andreasengert therapyrelatedmyeloidneoplasmsinpatientstreatedforhodgkinlymphoma |