Addressing brain metabolic connectivity in treatment-resistant schizophrenia: a novel graph theory-driven application of 18F-FDG-PET with antipsychotic dose correction

Addressing brain metabolic connectivity in treatment-resistant schizophrenia: a novel graph theory-driven application of 18F-FDG-PET with antipsychotic dose correction

Abstract Few studies using Positron Emission Tomography with 18F-fluorodeoxyglucose (18F-FDG-PET) have examined the neurobiological basis of antipsychotic resistance in schizophrenia, primarily focusing on metabolic activity, with none investigating connectivity patterns. Here, we aimed to explore d...

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Bibliographic Details
Main Authors: Giuseppe De Simone, Felice Iasevoli, Annarita Barone, Valeria Gaudieri, Alberto Cuocolo, Mariateresa Ciccarelli, Sabina Pappatà, Andrea de Bartolomeis
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Schizophrenia
Online Access:https://doi.org/10.1038/s41537-024-00535-4
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