Chronic Hepatitis C: An Overview of Evidence on Epidemiology and Management from a Brazilian Perspective
Chronic hepatitis C remains one of the main causes of chronic liver disease worldwide and presents a variable natural history ranging from minimal changes to advanced fibrosis and cirrhosis and its complications, such as development of hepatocellular carcinoma. Approximately, 1.45 million people are...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | International Journal of Hepatology |
| Online Access: | http://dx.doi.org/10.1155/2015/852968 |
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| author | Rodolfo Castro Hugo Perazzo Beatriz Grinsztejn Valdilea G. Veloso Chris Hyde |
| author_facet | Rodolfo Castro Hugo Perazzo Beatriz Grinsztejn Valdilea G. Veloso Chris Hyde |
| author_sort | Rodolfo Castro |
| collection | DOAJ |
| description | Chronic hepatitis C remains one of the main causes of chronic liver disease worldwide and presents a variable natural history ranging from minimal changes to advanced fibrosis and cirrhosis and its complications, such as development of hepatocellular carcinoma. Approximately, 1.45 million people are estimated to be infected by HCV in Brazil representing a major public health issue. The aim of this paper was to review the epidemiology and management of chronic hepatitis C from a Brazilian perspective. The management of chronic hepatitis C has been challenged by the use of noninvasive methods to stage liver fibrosis as an alternative to liver biopsy and the high cost of new interferon-free antiviral treatments. Moreover, the need of cost-effectiveness analysis in hepatitis C and the recent changes in treatment protocols were discussed. |
| format | Article |
| id | doaj-art-4abedd02a0494f9cb701f15ea03419b4 |
| institution | OA Journals |
| issn | 2090-3448 2090-3456 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hepatology |
| spelling | doaj-art-4abedd02a0494f9cb701f15ea03419b42025-08-20T02:38:03ZengWileyInternational Journal of Hepatology2090-34482090-34562015-01-01201510.1155/2015/852968852968Chronic Hepatitis C: An Overview of Evidence on Epidemiology and Management from a Brazilian PerspectiveRodolfo Castro0Hugo Perazzo1Beatriz Grinsztejn2Valdilea G. Veloso3Chris Hyde4Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Laboratory of Clinical Research on STD/AIDS, Avenida Brasil 4365, 21040-900 Manguinhos, RJ, BrazilEvandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Laboratory of Clinical Research on STD/AIDS, Avenida Brasil 4365, 21040-900 Manguinhos, RJ, BrazilEvandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Laboratory of Clinical Research on STD/AIDS, Avenida Brasil 4365, 21040-900 Manguinhos, RJ, BrazilEvandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Laboratory of Clinical Research on STD/AIDS, Avenida Brasil 4365, 21040-900 Manguinhos, RJ, BrazilInstitute of Health Research, Peninsula Technology Assessment Group (PenTAG), Evidence Synthesis and Modelling for Health Improvement (ESMI), University of Exeter Medical School, University of Exeter, St Luke’s Campus, South Cloisters, Exeter EX1 2LU, UKChronic hepatitis C remains one of the main causes of chronic liver disease worldwide and presents a variable natural history ranging from minimal changes to advanced fibrosis and cirrhosis and its complications, such as development of hepatocellular carcinoma. Approximately, 1.45 million people are estimated to be infected by HCV in Brazil representing a major public health issue. The aim of this paper was to review the epidemiology and management of chronic hepatitis C from a Brazilian perspective. The management of chronic hepatitis C has been challenged by the use of noninvasive methods to stage liver fibrosis as an alternative to liver biopsy and the high cost of new interferon-free antiviral treatments. Moreover, the need of cost-effectiveness analysis in hepatitis C and the recent changes in treatment protocols were discussed.http://dx.doi.org/10.1155/2015/852968 |
| spellingShingle | Rodolfo Castro Hugo Perazzo Beatriz Grinsztejn Valdilea G. Veloso Chris Hyde Chronic Hepatitis C: An Overview of Evidence on Epidemiology and Management from a Brazilian Perspective International Journal of Hepatology |
| title | Chronic Hepatitis C: An Overview of Evidence on Epidemiology and Management from a Brazilian Perspective |
| title_full | Chronic Hepatitis C: An Overview of Evidence on Epidemiology and Management from a Brazilian Perspective |
| title_fullStr | Chronic Hepatitis C: An Overview of Evidence on Epidemiology and Management from a Brazilian Perspective |
| title_full_unstemmed | Chronic Hepatitis C: An Overview of Evidence on Epidemiology and Management from a Brazilian Perspective |
| title_short | Chronic Hepatitis C: An Overview of Evidence on Epidemiology and Management from a Brazilian Perspective |
| title_sort | chronic hepatitis c an overview of evidence on epidemiology and management from a brazilian perspective |
| url | http://dx.doi.org/10.1155/2015/852968 |
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