Triiodothyronine activates THRβ to promote PGC1α expression alleviating PQ-induced pulmonary fibrosis

Triiodothyronine activates THRβ to promote PGC1α expression alleviating PQ-induced pulmonary fibrosis

Thyroid hormone (TH) and it most active form triiodothyronine (T3) are crucial in promoting mitochondrial biogenesis and maintaining cellular homeostasis during the stress response, but their role in paraquat (PQ)-induced pulmonary fibrosis isunclear. The aim of this study was to examine whether the...

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Bibliographic Details
Main Authors: Wenbo Chen, Zhengguang Geng, Haixia Luo, Zhaoyuan Huang, Yufen Yang, Xun Luo, Bao Fu, Zhi Liu, Xiaoyun Fu
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Thyroid hormone
Triiodothyronine
Fibrosis
Paraquat
PGC1α
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651325000491
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