Highly Sensitive Temperature Sensing in Biological Region with Ratiometric Fluorescent Response
Poly(2-oxazoline) (POx), a typical thermoresponsive polymer with good biocompatibility, was conjugated with environment-sensitive tetraphenylenethene (TPE) and hydroxyphenylbenzoxazole (HBO) to achieve unique thermometer readings. Through phase transition induced by temperature, the thermometers can...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-02-01
|
| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/30/5/1121 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850053262883946496 |
|---|---|
| author | Yan Li Han Yu Hongjuan Li Shiguo Sun Ruijin Yu Yongqian Xu |
| author_facet | Yan Li Han Yu Hongjuan Li Shiguo Sun Ruijin Yu Yongqian Xu |
| author_sort | Yan Li |
| collection | DOAJ |
| description | Poly(2-oxazoline) (POx), a typical thermoresponsive polymer with good biocompatibility, was conjugated with environment-sensitive tetraphenylenethene (TPE) and hydroxyphenylbenzoxazole (HBO) to achieve unique thermometer readings. Through phase transition induced by temperature, the thermometers can measure temperature in biologic range with ratiometric fluorescence response, ultrahigh sensitivity and good reversibility. Moreover, the thermometer can be used to measure the change in temperature with large fluorescence difference in living cells. |
| format | Article |
| id | doaj-art-4abb1be4ad8b47c885b2caf3c9edbf6e |
| institution | DOAJ |
| issn | 1420-3049 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj-art-4abb1be4ad8b47c885b2caf3c9edbf6e2025-08-20T02:52:35ZengMDPI AGMolecules1420-30492025-02-01305112110.3390/molecules30051121Highly Sensitive Temperature Sensing in Biological Region with Ratiometric Fluorescent ResponseYan Li0Han Yu1Hongjuan Li2Shiguo Sun3Ruijin Yu4Yongqian Xu5College of Chemistry & Pharmacy, Northwest A&F University, Yangling 712100, ChinaCollege of Chemistry & Pharmacy, Northwest A&F University, Yangling 712100, ChinaCollege of Chemistry & Pharmacy, Northwest A&F University, Yangling 712100, ChinaCollege of Chemistry & Pharmacy, Northwest A&F University, Yangling 712100, ChinaCollege of Chemistry & Pharmacy, Northwest A&F University, Yangling 712100, ChinaCollege of Chemistry & Pharmacy, Northwest A&F University, Yangling 712100, ChinaPoly(2-oxazoline) (POx), a typical thermoresponsive polymer with good biocompatibility, was conjugated with environment-sensitive tetraphenylenethene (TPE) and hydroxyphenylbenzoxazole (HBO) to achieve unique thermometer readings. Through phase transition induced by temperature, the thermometers can measure temperature in biologic range with ratiometric fluorescence response, ultrahigh sensitivity and good reversibility. Moreover, the thermometer can be used to measure the change in temperature with large fluorescence difference in living cells.https://www.mdpi.com/1420-3049/30/5/1121ratiometric fluorescencetemperature sensorsPoly(2-oxazoline) |
| spellingShingle | Yan Li Han Yu Hongjuan Li Shiguo Sun Ruijin Yu Yongqian Xu Highly Sensitive Temperature Sensing in Biological Region with Ratiometric Fluorescent Response Molecules ratiometric fluorescence temperature sensors Poly(2-oxazoline) |
| title | Highly Sensitive Temperature Sensing in Biological Region with Ratiometric Fluorescent Response |
| title_full | Highly Sensitive Temperature Sensing in Biological Region with Ratiometric Fluorescent Response |
| title_fullStr | Highly Sensitive Temperature Sensing in Biological Region with Ratiometric Fluorescent Response |
| title_full_unstemmed | Highly Sensitive Temperature Sensing in Biological Region with Ratiometric Fluorescent Response |
| title_short | Highly Sensitive Temperature Sensing in Biological Region with Ratiometric Fluorescent Response |
| title_sort | highly sensitive temperature sensing in biological region with ratiometric fluorescent response |
| topic | ratiometric fluorescence temperature sensors Poly(2-oxazoline) |
| url | https://www.mdpi.com/1420-3049/30/5/1121 |
| work_keys_str_mv | AT yanli highlysensitivetemperaturesensinginbiologicalregionwithratiometricfluorescentresponse AT hanyu highlysensitivetemperaturesensinginbiologicalregionwithratiometricfluorescentresponse AT hongjuanli highlysensitivetemperaturesensinginbiologicalregionwithratiometricfluorescentresponse AT shiguosun highlysensitivetemperaturesensinginbiologicalregionwithratiometricfluorescentresponse AT ruijinyu highlysensitivetemperaturesensinginbiologicalregionwithratiometricfluorescentresponse AT yongqianxu highlysensitivetemperaturesensinginbiologicalregionwithratiometricfluorescentresponse |