Comparative Evaluation of Lipid Profile, C-Reactive Protein and Paraoxonase-1 Activity in Dogs with Inflammatory Protein-Losing Enteropathy and Healthy Dogs
Chronic inflammation alters lipoprotein metabolism and causes changes in the serum concentrations of lipids, C-reactive protein (CRP), and paraoxonase-1 activity (PON-1), an enzyme that may act as a local detoxifier, antioxidant, and immunomodulator in the gastrointestinal tract. Scarce information...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-10-01
|
| Series: | Animals |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-2615/14/21/3119 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850197129789702144 |
|---|---|
| author | Paola Gianella Federica Cagnasso Alessia Giordano Antonio Borrelli Enrico Bottero Barbara Bruno Riccardo Ferriani Franca Borella Sara Meazzi Donatella Scavone Saverio Paltrinieri |
| author_facet | Paola Gianella Federica Cagnasso Alessia Giordano Antonio Borrelli Enrico Bottero Barbara Bruno Riccardo Ferriani Franca Borella Sara Meazzi Donatella Scavone Saverio Paltrinieri |
| author_sort | Paola Gianella |
| collection | DOAJ |
| description | Chronic inflammation alters lipoprotein metabolism and causes changes in the serum concentrations of lipids, C-reactive protein (CRP), and paraoxonase-1 activity (PON-1), an enzyme that may act as a local detoxifier, antioxidant, and immunomodulator in the gastrointestinal tract. Scarce information is available in dogs with protein-losing enteropathy secondary to chronic enteropathy (iPLE). The first aim was to describe and compare the lipid profiles, CRP concentrations and PON-1 activities in healthy dogs and in dogs with iPLE. The second aim was to evaluate correlations among clinicopathological, histologic data and lipid profiles in dogs with iPLE. Serum samples from 51 iPLE and 40 healthy dogs were used to study albumin, total protein, CRP, PON-1 activity, cholesterol, triglycerides and lipoprotein classes. Serum concentrations of albumin, total protein, cholesterol, PON-1 activity, and high-density and very-low-density lipoproteins were lower in iPLE dogs compared to healthy controls, while those of triglycerides, low-density lipoproteins, chylomicrons and CRP were higher. Significant correlations between the lipid profile and the existing chronic enteropathy activity index were not found. High-density and low-density lipoproteins correlated with CRP and PON-1. Triglycerides were significantly higher in dogs with both inflammation and lymphangiectasia. The results need to be confirmed in further studies. |
| format | Article |
| id | doaj-art-4ab6e7ff8d504f738a8ce9af1a41d271 |
| institution | OA Journals |
| issn | 2076-2615 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Animals |
| spelling | doaj-art-4ab6e7ff8d504f738a8ce9af1a41d2712025-08-20T02:13:15ZengMDPI AGAnimals2076-26152024-10-011421311910.3390/ani14213119Comparative Evaluation of Lipid Profile, C-Reactive Protein and Paraoxonase-1 Activity in Dogs with Inflammatory Protein-Losing Enteropathy and Healthy DogsPaola Gianella0Federica Cagnasso1Alessia Giordano2Antonio Borrelli3Enrico Bottero4Barbara Bruno5Riccardo Ferriani6Franca Borella7Sara Meazzi8Donatella Scavone9Saverio Paltrinieri10Department of Veterinary Sciences, University of Turin, Largo P. Braccini 2, 10095 Grugliasco, ItalyDepartment of Veterinary Sciences, University of Turin, Largo P. Braccini 2, 10095 Grugliasco, ItalyDepartment of Veterinary Medicine and Animal Sciences, University of Milan, Via dell’Università 6, 26900 Lodi, ItalyDepartment of Veterinary Sciences, University of Turin, Largo P. Braccini 2, 10095 Grugliasco, ItalyEndovet Italia, Via A. Oroboni, 00100 Roma, ItalyDepartment of Veterinary Sciences, University of Turin, Largo P. Braccini 2, 10095 Grugliasco, ItalyEndovet Italia, Via A. Oroboni, 00100 Roma, ItalyDepartment of Veterinary Sciences, University of Turin, Largo P. Braccini 2, 10095 Grugliasco, ItalyDepartment of Veterinary Medicine and Animal Sciences, University of Milan, Via dell’Università 6, 26900 Lodi, ItalyDepartment of Veterinary Medicine and Animal Sciences, University of Milan, Via dell’Università 6, 26900 Lodi, ItalyDepartment of Veterinary Medicine and Animal Sciences, University of Milan, Via dell’Università 6, 26900 Lodi, ItalyChronic inflammation alters lipoprotein metabolism and causes changes in the serum concentrations of lipids, C-reactive protein (CRP), and paraoxonase-1 activity (PON-1), an enzyme that may act as a local detoxifier, antioxidant, and immunomodulator in the gastrointestinal tract. Scarce information is available in dogs with protein-losing enteropathy secondary to chronic enteropathy (iPLE). The first aim was to describe and compare the lipid profiles, CRP concentrations and PON-1 activities in healthy dogs and in dogs with iPLE. The second aim was to evaluate correlations among clinicopathological, histologic data and lipid profiles in dogs with iPLE. Serum samples from 51 iPLE and 40 healthy dogs were used to study albumin, total protein, CRP, PON-1 activity, cholesterol, triglycerides and lipoprotein classes. Serum concentrations of albumin, total protein, cholesterol, PON-1 activity, and high-density and very-low-density lipoproteins were lower in iPLE dogs compared to healthy controls, while those of triglycerides, low-density lipoproteins, chylomicrons and CRP were higher. Significant correlations between the lipid profile and the existing chronic enteropathy activity index were not found. High-density and low-density lipoproteins correlated with CRP and PON-1. Triglycerides were significantly higher in dogs with both inflammation and lymphangiectasia. The results need to be confirmed in further studies.https://www.mdpi.com/2076-2615/14/21/3119caninechronic enteropathycholesterolCRPIBDlipoprotein |
| spellingShingle | Paola Gianella Federica Cagnasso Alessia Giordano Antonio Borrelli Enrico Bottero Barbara Bruno Riccardo Ferriani Franca Borella Sara Meazzi Donatella Scavone Saverio Paltrinieri Comparative Evaluation of Lipid Profile, C-Reactive Protein and Paraoxonase-1 Activity in Dogs with Inflammatory Protein-Losing Enteropathy and Healthy Dogs Animals canine chronic enteropathy cholesterol CRP IBD lipoprotein |
| title | Comparative Evaluation of Lipid Profile, C-Reactive Protein and Paraoxonase-1 Activity in Dogs with Inflammatory Protein-Losing Enteropathy and Healthy Dogs |
| title_full | Comparative Evaluation of Lipid Profile, C-Reactive Protein and Paraoxonase-1 Activity in Dogs with Inflammatory Protein-Losing Enteropathy and Healthy Dogs |
| title_fullStr | Comparative Evaluation of Lipid Profile, C-Reactive Protein and Paraoxonase-1 Activity in Dogs with Inflammatory Protein-Losing Enteropathy and Healthy Dogs |
| title_full_unstemmed | Comparative Evaluation of Lipid Profile, C-Reactive Protein and Paraoxonase-1 Activity in Dogs with Inflammatory Protein-Losing Enteropathy and Healthy Dogs |
| title_short | Comparative Evaluation of Lipid Profile, C-Reactive Protein and Paraoxonase-1 Activity in Dogs with Inflammatory Protein-Losing Enteropathy and Healthy Dogs |
| title_sort | comparative evaluation of lipid profile c reactive protein and paraoxonase 1 activity in dogs with inflammatory protein losing enteropathy and healthy dogs |
| topic | canine chronic enteropathy cholesterol CRP IBD lipoprotein |
| url | https://www.mdpi.com/2076-2615/14/21/3119 |
| work_keys_str_mv | AT paolagianella comparativeevaluationoflipidprofilecreactiveproteinandparaoxonase1activityindogswithinflammatoryproteinlosingenteropathyandhealthydogs AT federicacagnasso comparativeevaluationoflipidprofilecreactiveproteinandparaoxonase1activityindogswithinflammatoryproteinlosingenteropathyandhealthydogs AT alessiagiordano comparativeevaluationoflipidprofilecreactiveproteinandparaoxonase1activityindogswithinflammatoryproteinlosingenteropathyandhealthydogs AT antonioborrelli comparativeevaluationoflipidprofilecreactiveproteinandparaoxonase1activityindogswithinflammatoryproteinlosingenteropathyandhealthydogs AT enricobottero comparativeevaluationoflipidprofilecreactiveproteinandparaoxonase1activityindogswithinflammatoryproteinlosingenteropathyandhealthydogs AT barbarabruno comparativeevaluationoflipidprofilecreactiveproteinandparaoxonase1activityindogswithinflammatoryproteinlosingenteropathyandhealthydogs AT riccardoferriani comparativeevaluationoflipidprofilecreactiveproteinandparaoxonase1activityindogswithinflammatoryproteinlosingenteropathyandhealthydogs AT francaborella comparativeevaluationoflipidprofilecreactiveproteinandparaoxonase1activityindogswithinflammatoryproteinlosingenteropathyandhealthydogs AT sarameazzi comparativeevaluationoflipidprofilecreactiveproteinandparaoxonase1activityindogswithinflammatoryproteinlosingenteropathyandhealthydogs AT donatellascavone comparativeevaluationoflipidprofilecreactiveproteinandparaoxonase1activityindogswithinflammatoryproteinlosingenteropathyandhealthydogs AT saveriopaltrinieri comparativeevaluationoflipidprofilecreactiveproteinandparaoxonase1activityindogswithinflammatoryproteinlosingenteropathyandhealthydogs |