Tumor Microenvironment‐Responsive Nanoparticles Enhance IDO1 Blockade Immunotherapy by Remodeling Metabolic Immunosuppression

Tumor Microenvironment‐Responsive Nanoparticles Enhance IDO1 Blockade Immunotherapy by Remodeling Metabolic Immunosuppression

Abstract The clinical efficacy of immune checkpoint blockade (ICB) therapy is significantly compromised in the metabolically disordered tumor microenvironment (TME), posing a formidable challenge that cannot be ignored in current antitumor strategies. In this study, TME‐responsive nanoparticles (HMP...

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Bibliographic Details
Main Authors: Mengna Wang, Yuhong Liu, Yanshi Li, Tao Lu, Min Wang, Zhaobo Cheng, Lin Chen, Tongling Wen, Min Pan, Guohua Hu
Format: Article
Language:English
Published: Wiley 2025-02-01
Series:Advanced Science
Subjects:
chemodymic therapy
immunosuppression
indoleamine 2,3‐dioxygenase 1
KYN/TRP metabolism
Online Access:https://doi.org/10.1002/advs.202405845
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