Synthesis, Structural Analysis, and Biological Activities of Some Imidazolium Salts
Four newly synthesized imidazolium salts were characterized by nuclear magnetic resonance, vibrational spectra, and mass spectra. Then, the density functional theory calculations were performed to obtain the molecular configurations on which the theoretical nuclear magnetic resonance and infrared sp...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Bioinorganic Chemistry and Applications |
| Online Access: | http://dx.doi.org/10.1155/2018/1439810 |
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| author | Gühergül Uluçam Murat Turkyilmaz |
| author_facet | Gühergül Uluçam Murat Turkyilmaz |
| author_sort | Gühergül Uluçam |
| collection | DOAJ |
| description | Four newly synthesized imidazolium salts were characterized by nuclear magnetic resonance, vibrational spectra, and mass spectra. Then, the density functional theory calculations were performed to obtain the molecular configurations on which the theoretical nuclear magnetic resonance and infrared spectra were consequently obtained. The comparison of calculated spectra with the experimental spectra for each molecule leads to the conclusion that the theoretical results can be assumed to be a good approach to their molecular configurations. The in vitro biological activities of the salts on the selected bacteria and cancer cell lines were determined by using the broth dilution method according to Clinical and Laboratory Standards Institute guidelines. The 1,3-bis(2-hydroxyethyl) imidazolidinium bromide and 3-(2-ethoxy-2-oxoethly)-1-(3-aminopropyl)-1H-imidazol-3-ium bromide showed efficiency on Bacillus cereus ATCC 11778. The 3-bis(2-carboxyethyl)-4-methyl-1-H-imidazol-3-ium bromide was effective on HeLa while a similar effect was observed on Hep G2 with 3-(2-carboxyethyl)-1-(3-aminopropyl)-1H-imidazol-3-ium bromide. |
| format | Article |
| id | doaj-art-4aa8d07dde90466ab40d433e2816b205 |
| institution | DOAJ |
| issn | 1565-3633 1687-479X |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Bioinorganic Chemistry and Applications |
| spelling | doaj-art-4aa8d07dde90466ab40d433e2816b2052025-08-20T03:20:16ZengWileyBioinorganic Chemistry and Applications1565-36331687-479X2018-01-01201810.1155/2018/14398101439810Synthesis, Structural Analysis, and Biological Activities of Some Imidazolium SaltsGühergül Uluçam0Murat Turkyilmaz1Department of Chemistry, Trakya University, 22030 Edirne, TurkeyDepartment of Chemistry, Trakya University, 22030 Edirne, TurkeyFour newly synthesized imidazolium salts were characterized by nuclear magnetic resonance, vibrational spectra, and mass spectra. Then, the density functional theory calculations were performed to obtain the molecular configurations on which the theoretical nuclear magnetic resonance and infrared spectra were consequently obtained. The comparison of calculated spectra with the experimental spectra for each molecule leads to the conclusion that the theoretical results can be assumed to be a good approach to their molecular configurations. The in vitro biological activities of the salts on the selected bacteria and cancer cell lines were determined by using the broth dilution method according to Clinical and Laboratory Standards Institute guidelines. The 1,3-bis(2-hydroxyethyl) imidazolidinium bromide and 3-(2-ethoxy-2-oxoethly)-1-(3-aminopropyl)-1H-imidazol-3-ium bromide showed efficiency on Bacillus cereus ATCC 11778. The 3-bis(2-carboxyethyl)-4-methyl-1-H-imidazol-3-ium bromide was effective on HeLa while a similar effect was observed on Hep G2 with 3-(2-carboxyethyl)-1-(3-aminopropyl)-1H-imidazol-3-ium bromide.http://dx.doi.org/10.1155/2018/1439810 |
| spellingShingle | Gühergül Uluçam Murat Turkyilmaz Synthesis, Structural Analysis, and Biological Activities of Some Imidazolium Salts Bioinorganic Chemistry and Applications |
| title | Synthesis, Structural Analysis, and Biological Activities of Some Imidazolium Salts |
| title_full | Synthesis, Structural Analysis, and Biological Activities of Some Imidazolium Salts |
| title_fullStr | Synthesis, Structural Analysis, and Biological Activities of Some Imidazolium Salts |
| title_full_unstemmed | Synthesis, Structural Analysis, and Biological Activities of Some Imidazolium Salts |
| title_short | Synthesis, Structural Analysis, and Biological Activities of Some Imidazolium Salts |
| title_sort | synthesis structural analysis and biological activities of some imidazolium salts |
| url | http://dx.doi.org/10.1155/2018/1439810 |
| work_keys_str_mv | AT guhergululucam synthesisstructuralanalysisandbiologicalactivitiesofsomeimidazoliumsalts AT muratturkyilmaz synthesisstructuralanalysisandbiologicalactivitiesofsomeimidazoliumsalts |