A comprehensive review of cancer drug nanoparticles synthesis, processing technology and its effect in drug delivery
The advent of nanotechnology has significantly advanced cancer treatment by introducing innovative approaches to targeted drug delivery and enhanced therapeutic efficiency. Nano drugs and nanocarriers, owing to their nanoscale dimensions, extensive surface area, and ability to modulate biodistributi...
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| Format: | Article |
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KeAi Communications Co., Ltd.
2025-06-01
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| Series: | Biomedical Technology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2949723X25000170 |
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| author | Mujibur Khan Jannatul Ferdaus Khaleda Akter Hossain Ahmed Mahrima Parvin Sawaiz Kashif Ali S. Arbab |
| author_facet | Mujibur Khan Jannatul Ferdaus Khaleda Akter Hossain Ahmed Mahrima Parvin Sawaiz Kashif Ali S. Arbab |
| author_sort | Mujibur Khan |
| collection | DOAJ |
| description | The advent of nanotechnology has significantly advanced cancer treatment by introducing innovative approaches to targeted drug delivery and enhanced therapeutic efficiency. Nano drugs and nanocarriers, owing to their nanoscale dimensions, extensive surface area, and ability to modulate biodistribution, have proven effective in localizing tumor sites and enabling sustained drug release. These properties result in greater cytotoxicity and minimize systemic side effects compared to conventional therapies. Moreover, nanoparticles can be functionalized with molecular targeting agents, such as peptides, and combined with imaging dyes to improve the precision and monitoring of in-vivo treatments. A promising development in this domain is the utilization of biological carriers, particularly exosomes. These extracellular vesicles (30–150 nm in size) are secreted by various cells and possess a unique capacity to influence the tumor microenvironment through intercellular interactions and direct fusion with cell membranes. This review examines recent advancements in cancer drug delivery, with an emphasis on the design and processing of nano drugs and evaluates the potential of engineered exosomes as a transformative modality in cancer therapeutics. |
| format | Article |
| id | doaj-art-4aa83c0cbed644938b893e862c858328 |
| institution | Kabale University |
| issn | 2949-723X |
| language | English |
| publishDate | 2025-06-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Biomedical Technology |
| spelling | doaj-art-4aa83c0cbed644938b893e862c8583282025-08-20T03:24:45ZengKeAi Communications Co., Ltd.Biomedical Technology2949-723X2025-06-011010008510.1016/j.bmt.2025.100085A comprehensive review of cancer drug nanoparticles synthesis, processing technology and its effect in drug deliveryMujibur Khan0Jannatul Ferdaus1Khaleda Akter2Hossain Ahmed3Mahrima Parvin4Sawaiz Kashif5Ali S. Arbab6Mechanical Engineering Department, Georgia Southern University, Statesboro, GA, 30458, USA; Corresponding author.Mechanical Engineering Department, Georgia Southern University, Statesboro, GA, 30458, USAMechanical Engineering Department, Georgia Southern University, Statesboro, GA, 30458, USAMechanical Engineering Department, Georgia Southern University, Statesboro, GA, 30458, USATumor Angiogenesis Lab, Georgia Cancer Center, Augusta University, Augusta, GA, 30912, USATumor Angiogenesis Lab, Georgia Cancer Center, Augusta University, Augusta, GA, 30912, USATumor Angiogenesis Lab, Georgia Cancer Center, Augusta University, Augusta, GA, 30912, USAThe advent of nanotechnology has significantly advanced cancer treatment by introducing innovative approaches to targeted drug delivery and enhanced therapeutic efficiency. Nano drugs and nanocarriers, owing to their nanoscale dimensions, extensive surface area, and ability to modulate biodistribution, have proven effective in localizing tumor sites and enabling sustained drug release. These properties result in greater cytotoxicity and minimize systemic side effects compared to conventional therapies. Moreover, nanoparticles can be functionalized with molecular targeting agents, such as peptides, and combined with imaging dyes to improve the precision and monitoring of in-vivo treatments. A promising development in this domain is the utilization of biological carriers, particularly exosomes. These extracellular vesicles (30–150 nm in size) are secreted by various cells and possess a unique capacity to influence the tumor microenvironment through intercellular interactions and direct fusion with cell membranes. This review examines recent advancements in cancer drug delivery, with an emphasis on the design and processing of nano drugs and evaluates the potential of engineered exosomes as a transformative modality in cancer therapeutics.http://www.sciencedirect.com/science/article/pii/S2949723X25000170NanomedicineTargeted therapyNanoparticle engineeringNano drugsDrug deliveryExosomes |
| spellingShingle | Mujibur Khan Jannatul Ferdaus Khaleda Akter Hossain Ahmed Mahrima Parvin Sawaiz Kashif Ali S. Arbab A comprehensive review of cancer drug nanoparticles synthesis, processing technology and its effect in drug delivery Biomedical Technology Nanomedicine Targeted therapy Nanoparticle engineering Nano drugs Drug delivery Exosomes |
| title | A comprehensive review of cancer drug nanoparticles synthesis, processing technology and its effect in drug delivery |
| title_full | A comprehensive review of cancer drug nanoparticles synthesis, processing technology and its effect in drug delivery |
| title_fullStr | A comprehensive review of cancer drug nanoparticles synthesis, processing technology and its effect in drug delivery |
| title_full_unstemmed | A comprehensive review of cancer drug nanoparticles synthesis, processing technology and its effect in drug delivery |
| title_short | A comprehensive review of cancer drug nanoparticles synthesis, processing technology and its effect in drug delivery |
| title_sort | comprehensive review of cancer drug nanoparticles synthesis processing technology and its effect in drug delivery |
| topic | Nanomedicine Targeted therapy Nanoparticle engineering Nano drugs Drug delivery Exosomes |
| url | http://www.sciencedirect.com/science/article/pii/S2949723X25000170 |
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