Research progress on pathophysiologic mechanisms, clinical treatment and predictive biomarkers in bronchopulmonary dysplasia: from the perspective of oxidative stress
With the global rise in preterm birth rates, bronchopulmonary dysplasia (BPD) continues to be a significant problem, affecting morbidity and mortality in surviving preterm infants. Preterm infants are particularly susceptible to oxidative stress induced by sudden increases in oxygen concentration, w...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-03-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2024.1343870/full |
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| author | Min Li Min Li Min Li Wen-Xiang Cheng Shuo Li Jing Wang Yan-Rui Chen Liang Li Gui Yang Gui Yang |
| author_facet | Min Li Min Li Min Li Wen-Xiang Cheng Shuo Li Jing Wang Yan-Rui Chen Liang Li Gui Yang Gui Yang |
| author_sort | Min Li |
| collection | DOAJ |
| description | With the global rise in preterm birth rates, bronchopulmonary dysplasia (BPD) continues to be a significant problem, affecting morbidity and mortality in surviving preterm infants. Preterm infants are particularly susceptible to oxidative stress induced by sudden increases in oxygen concentration, which plays a crucial role in the pathogenesis of BPD. Herein, we addressed the pathophysiologic mechanisms, clinical treatment, and predictive biomarkers of BPD from an oxidative stress perspective. We first review the importance of oxygen in preterm infants and point out that sustained exposure to hyperoxia exacerbates the susceptibility of the immature lung to free radicals. The antioxidant properties of clinical therapies for BPD in preterm infants are then summarized. Subsequently, based on lipid, protein, and DNA damage mechanisms, we obtained the most comprehensive, accurate, and representative oxidative stress biomarkers. A total of 37 research papers on oxidative stress in BPD were collected. We conclude that 8-OHdG is the most promising biomarker for early prediction of BPD pathogenesis compared to lipid and protein oxidative stress biomarkers. |
| format | Article |
| id | doaj-art-4aa746f5ef7d4cd1a779437360e9e232 |
| institution | DOAJ |
| issn | 2296-2360 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj-art-4aa746f5ef7d4cd1a779437360e9e2322025-08-20T02:54:03ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602025-03-011210.3389/fped.2024.13438701343870Research progress on pathophysiologic mechanisms, clinical treatment and predictive biomarkers in bronchopulmonary dysplasia: from the perspective of oxidative stressMin Li0Min Li1Min Li2Wen-Xiang Cheng3Shuo Li4Jing Wang5Yan-Rui Chen6Liang Li7Gui Yang8Gui Yang9Department of Otolaryngology, Longgang Central Hospital, Shenzhen, ChinaShenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, ChinaGuangxi Hospital Division of the First Affiliated Hospital, Sun Yat-sen University, Nanning, ChinaShenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, ChinaDepartment of Otolaryngology, Huazhong University of Science and Technology Union Shenzhen Hospital, Shenzhen, ChinaDepartment of Otolaryngology, Longgang Central Hospital, Shenzhen, ChinaDepartment of Otolaryngology, Longgang Central Hospital, Shenzhen, ChinaSchool of Medicine, Southern University of Science and Technology, Shenzhen, ChinaDepartment of Otolaryngology, Longgang Central Hospital, Shenzhen, ChinaDepartment of Otolaryngology & Allergy Center, The Central Hospital of Shenzhen Longgang District, Shenzhen, ChinaWith the global rise in preterm birth rates, bronchopulmonary dysplasia (BPD) continues to be a significant problem, affecting morbidity and mortality in surviving preterm infants. Preterm infants are particularly susceptible to oxidative stress induced by sudden increases in oxygen concentration, which plays a crucial role in the pathogenesis of BPD. Herein, we addressed the pathophysiologic mechanisms, clinical treatment, and predictive biomarkers of BPD from an oxidative stress perspective. We first review the importance of oxygen in preterm infants and point out that sustained exposure to hyperoxia exacerbates the susceptibility of the immature lung to free radicals. The antioxidant properties of clinical therapies for BPD in preterm infants are then summarized. Subsequently, based on lipid, protein, and DNA damage mechanisms, we obtained the most comprehensive, accurate, and representative oxidative stress biomarkers. A total of 37 research papers on oxidative stress in BPD were collected. We conclude that 8-OHdG is the most promising biomarker for early prediction of BPD pathogenesis compared to lipid and protein oxidative stress biomarkers.https://www.frontiersin.org/articles/10.3389/fped.2024.1343870/fullbronchopulmonary dysplasiahyperoxia exposureoxidative stressantioxidant treatmentspredictive biomarkers |
| spellingShingle | Min Li Min Li Min Li Wen-Xiang Cheng Shuo Li Jing Wang Yan-Rui Chen Liang Li Gui Yang Gui Yang Research progress on pathophysiologic mechanisms, clinical treatment and predictive biomarkers in bronchopulmonary dysplasia: from the perspective of oxidative stress Frontiers in Pediatrics bronchopulmonary dysplasia hyperoxia exposure oxidative stress antioxidant treatments predictive biomarkers |
| title | Research progress on pathophysiologic mechanisms, clinical treatment and predictive biomarkers in bronchopulmonary dysplasia: from the perspective of oxidative stress |
| title_full | Research progress on pathophysiologic mechanisms, clinical treatment and predictive biomarkers in bronchopulmonary dysplasia: from the perspective of oxidative stress |
| title_fullStr | Research progress on pathophysiologic mechanisms, clinical treatment and predictive biomarkers in bronchopulmonary dysplasia: from the perspective of oxidative stress |
| title_full_unstemmed | Research progress on pathophysiologic mechanisms, clinical treatment and predictive biomarkers in bronchopulmonary dysplasia: from the perspective of oxidative stress |
| title_short | Research progress on pathophysiologic mechanisms, clinical treatment and predictive biomarkers in bronchopulmonary dysplasia: from the perspective of oxidative stress |
| title_sort | research progress on pathophysiologic mechanisms clinical treatment and predictive biomarkers in bronchopulmonary dysplasia from the perspective of oxidative stress |
| topic | bronchopulmonary dysplasia hyperoxia exposure oxidative stress antioxidant treatments predictive biomarkers |
| url | https://www.frontiersin.org/articles/10.3389/fped.2024.1343870/full |
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