Genome-wide association analysis of neutrophil granularity identifies CDK6 as a regulator of primary granules

Genome-wide association analysis of neutrophil granularity identifies CDK6 as a regulator of primary granules

Summary: Neutrophils are essential immune cells loaded with cytosolic granules that contain potent antimicrobial and immunostimulatory molecules. Alterations of neutrophil granule contents are associated with immunodeficiency and hyperinflammation. Identification of regulators of granule development...

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Main Authors: Kathryn Fleming, Kate Burley, Fernando Ponce-Garcia, Parsa Akbari, Claire Naveh, Chris Rice, Przemysław Zakrzewski, Willem Gibbs, Sarah Groves, Drinalda Cela, Venizelos Papayannopoulos, Christopher J. Harbort, Andrew Mumford, Borko Amulic
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:iScience
Subjects:
Biological sciences
Genetics
Immunology
Natural sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225013331
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