Elevated MS4A12 expression is indicative of resistance to concurrent chemoradiotherapy and inferior survival in patients with rectal cancer

Abstract Introduction In individuals presenting with locally advanced rectal cancer, the therapeutic strategy of neoadjuvant concurrent chemoradiotherapy (CCRT) aims to enhance tumor downstaging; however, only a subset of patients exhibit a favorable response. Molecular stratification, combined with...

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Main Authors: Chih-I Chen, Yi-Kai Kao, Po-Wen Yang, Pin-Chun Chen, Ching-Chieh Yang, Wan-Shan Li, Hsin-Hwa Tsai, Yu-Jen Wang, Hong-Yue Lai
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Radiation Oncology
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Online Access:https://doi.org/10.1186/s13014-025-02709-5
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