Analysis of the diagnostic efficacy of ultrasound, MRI, and combined examination in benign and malignant breast tumors
BackgroundTo compare the diagnostic effectiveness of ultrasound (US), magnetic resonance imaging (MRI), and their combined application in distinguishing between benign and malignant breast tumors, with particular emphasis on evaluating diagnostic performance in different breast densities—fatty breas...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1494862/full |
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| author | Dianpei Ma Dianpei Ma Changliang Wang Jie Li Jie Li Xiaohan Hao Yun Zhu Zhizhen Gao Zhizhen Gao Chun Liu Changfan Luo Yu Huang |
| author_facet | Dianpei Ma Dianpei Ma Changliang Wang Jie Li Jie Li Xiaohan Hao Yun Zhu Zhizhen Gao Zhizhen Gao Chun Liu Changfan Luo Yu Huang |
| author_sort | Dianpei Ma |
| collection | DOAJ |
| description | BackgroundTo compare the diagnostic effectiveness of ultrasound (US), magnetic resonance imaging (MRI), and their combined application in distinguishing between benign and malignant breast tumors, with particular emphasis on evaluating diagnostic performance in different breast densities—fatty breast tissue, where fat predominates, and dense breast tissue, which contains a significant amount of fibroglandular tissue.Materials and methodsA retrospective analysis was conducted on 185 patients with breast tumors, including 90 malignant and 95 benign cases. All patients underwent both US and MRI examinations within one week prior to surgery. The diagnostic accuracy of US, MRI, and their combined use in differentiating benign and malignant tumors was evaluated.ResultsThe combined examination demonstrated the highest area under the curve (AUC), sensitivity, and negative predictive value (NPV) (0.904, 90%, 90.4%), outperforming US (0.830, 73.3%, 78.6%) and MRI (0.897, 89.7%, 88.8%). DeLong test results revealed statistically significant differences in AUC between US and MRI, as well as between US and the combined examination (P < 0.05). However, the difference in AUC between MRI and the combined examination was not significant (P = 0.939). In patients with fatty breast tissue, no significant differences were found between MRI and US, or between MRI and the combined examination (P = 0.708 and P = 0.317, respectively). However, the diagnostic performance between US and the combined examination was statistically significant (P < 0.05). For patients with dense breast tissue, the differences in diagnostic performance between US and MRI, and between US and the combined examination, were significant (P < 0.05), while the difference between MRI and the combined examination was not significant (P = 0.317).ConclusionMRI and combined examination methods significantly enhance the ability to differentiate benign and malignant breast tumors and provide important clinical value for early breast cancer detection. |
| format | Article |
| id | doaj-art-4a930355d5804c15ab4c54f8644ab740 |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-4a930355d5804c15ab4c54f8644ab7402025-01-30T06:22:16ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-01-011510.3389/fonc.2025.14948621494862Analysis of the diagnostic efficacy of ultrasound, MRI, and combined examination in benign and malignant breast tumorsDianpei Ma0Dianpei Ma1Changliang Wang2Jie Li3Jie Li4Xiaohan Hao5Yun Zhu6Zhizhen Gao7Zhizhen Gao8Chun Liu9Changfan Luo10Yu Huang11School of Medical Imaging, Bengbu Medical University, Bengbu, ChinaDepartment of Radiology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, ChinaCollege of Information Science and Technology, University of Science and Technology of China, Hefei, ChinaSchool of Medical Imaging, Bengbu Medical University, Bengbu, ChinaDepartment of Radiology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Chinathe Research and Development Management Center of Anhui Fuqing Medical Equipment Co., Ltd., Hefei, ChinaDepartment of Radiology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, ChinaSchool of Medical Imaging, Bengbu Medical University, Bengbu, ChinaDepartment of Radiology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Chinathe Research and Development Management Center of Anhui Fuqing Medical Equipment Co., Ltd., Hefei, ChinaMedical Imaging Center, Department of Electronic Science, University of Science and Technology of China, Hefei, ChinaSchool of Medical Imaging, Bengbu Medical University, Bengbu, ChinaBackgroundTo compare the diagnostic effectiveness of ultrasound (US), magnetic resonance imaging (MRI), and their combined application in distinguishing between benign and malignant breast tumors, with particular emphasis on evaluating diagnostic performance in different breast densities—fatty breast tissue, where fat predominates, and dense breast tissue, which contains a significant amount of fibroglandular tissue.Materials and methodsA retrospective analysis was conducted on 185 patients with breast tumors, including 90 malignant and 95 benign cases. All patients underwent both US and MRI examinations within one week prior to surgery. The diagnostic accuracy of US, MRI, and their combined use in differentiating benign and malignant tumors was evaluated.ResultsThe combined examination demonstrated the highest area under the curve (AUC), sensitivity, and negative predictive value (NPV) (0.904, 90%, 90.4%), outperforming US (0.830, 73.3%, 78.6%) and MRI (0.897, 89.7%, 88.8%). DeLong test results revealed statistically significant differences in AUC between US and MRI, as well as between US and the combined examination (P < 0.05). However, the difference in AUC between MRI and the combined examination was not significant (P = 0.939). In patients with fatty breast tissue, no significant differences were found between MRI and US, or between MRI and the combined examination (P = 0.708 and P = 0.317, respectively). However, the diagnostic performance between US and the combined examination was statistically significant (P < 0.05). For patients with dense breast tissue, the differences in diagnostic performance between US and MRI, and between US and the combined examination, were significant (P < 0.05), while the difference between MRI and the combined examination was not significant (P = 0.317).ConclusionMRI and combined examination methods significantly enhance the ability to differentiate benign and malignant breast tumors and provide important clinical value for early breast cancer detection.https://www.frontiersin.org/articles/10.3389/fonc.2025.1494862/fullmagnetic resonance imagingultrasounddifferential diagnosisbreast cancerbreast tumors |
| spellingShingle | Dianpei Ma Dianpei Ma Changliang Wang Jie Li Jie Li Xiaohan Hao Yun Zhu Zhizhen Gao Zhizhen Gao Chun Liu Changfan Luo Yu Huang Analysis of the diagnostic efficacy of ultrasound, MRI, and combined examination in benign and malignant breast tumors Frontiers in Oncology magnetic resonance imaging ultrasound differential diagnosis breast cancer breast tumors |
| title | Analysis of the diagnostic efficacy of ultrasound, MRI, and combined examination in benign and malignant breast tumors |
| title_full | Analysis of the diagnostic efficacy of ultrasound, MRI, and combined examination in benign and malignant breast tumors |
| title_fullStr | Analysis of the diagnostic efficacy of ultrasound, MRI, and combined examination in benign and malignant breast tumors |
| title_full_unstemmed | Analysis of the diagnostic efficacy of ultrasound, MRI, and combined examination in benign and malignant breast tumors |
| title_short | Analysis of the diagnostic efficacy of ultrasound, MRI, and combined examination in benign and malignant breast tumors |
| title_sort | analysis of the diagnostic efficacy of ultrasound mri and combined examination in benign and malignant breast tumors |
| topic | magnetic resonance imaging ultrasound differential diagnosis breast cancer breast tumors |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1494862/full |
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