Autoimmunity and Extrahepatic Manifestations in Treatment-Naïve Children with Chronic Hepatitis C Virus Infection
Hepatitis C virus (HCV) infection has been associated with autoimmunity and extrahepatic manifestations in adults. Few data are available on these topics in children. Nonorgan specific auto-antibodies development is part of the natural course of chronic hepatitis C in children. Smooth muscle autoant...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2012/785627 |
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| author | Giuseppe Indolfi Elisa Bartolini Biagio Olivito Chiara Azzari Massimo Resti |
| author_facet | Giuseppe Indolfi Elisa Bartolini Biagio Olivito Chiara Azzari Massimo Resti |
| author_sort | Giuseppe Indolfi |
| collection | DOAJ |
| description | Hepatitis C virus (HCV) infection has been associated with autoimmunity and extrahepatic manifestations in adults. Few data are available on these topics in children. Nonorgan specific auto-antibodies development is part of the natural course of chronic hepatitis C in children. Smooth muscle autoantibody is the most common autoantibody found, while liver-kidney microsomal type-1 antibody positivity is the most peculiar autoimmune feature of children with HCV infection. The clinical significance of non-organ specific autoantibodies in the course of paediatric chronic hepatitis C is still debated. Autoantibody positivity can be considered neutral for most patients, while it can be associated with negative connotations for others, especially those positive for liver-kidney microsomal type-1 autoantibody. Subclinical hypothyroidism but not autoimmune thyroiditis has been demonstrated in HCV infection in children, while only few cases of HCV-associated membranoproliferative glomerulonephritis have been described. Single reports are available in the literature reporting the anecdotal association between chronic hepatitis C and other extrahepatic manifestations such as myopathy and opsoclonus-myoclonus syndrome. Despite the low incidence of extrahepatic manifestations of chronic hepatitis C in children, overall, available data suggest a careful monitoring. |
| format | Article |
| id | doaj-art-4a8ab661061f4a53bd52ee6a668af4c3 |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-4a8ab661061f4a53bd52ee6a668af4c32025-02-03T01:28:45ZengWileyClinical and Developmental Immunology1740-25221740-25302012-01-01201210.1155/2012/785627785627Autoimmunity and Extrahepatic Manifestations in Treatment-Naïve Children with Chronic Hepatitis C Virus InfectionGiuseppe Indolfi0Elisa Bartolini1Biagio Olivito2Chiara Azzari3Massimo Resti4Paediatric and Liver Unit, Meyer Children University Hospital of Florence, ItalyPaediatric and Liver Unit, Meyer Children University Hospital of Florence, ItalyImmunology Unit and Immunology Laboratory, Meyer Children University Hospital of Florence, Department of Sciences for Woman and Child's Health, University of Florence, Florence, ItalyImmunology Unit and Immunology Laboratory, Meyer Children University Hospital of Florence, Department of Sciences for Woman and Child's Health, University of Florence, Florence, ItalyPaediatric and Liver Unit, Meyer Children University Hospital of Florence, ItalyHepatitis C virus (HCV) infection has been associated with autoimmunity and extrahepatic manifestations in adults. Few data are available on these topics in children. Nonorgan specific auto-antibodies development is part of the natural course of chronic hepatitis C in children. Smooth muscle autoantibody is the most common autoantibody found, while liver-kidney microsomal type-1 antibody positivity is the most peculiar autoimmune feature of children with HCV infection. The clinical significance of non-organ specific autoantibodies in the course of paediatric chronic hepatitis C is still debated. Autoantibody positivity can be considered neutral for most patients, while it can be associated with negative connotations for others, especially those positive for liver-kidney microsomal type-1 autoantibody. Subclinical hypothyroidism but not autoimmune thyroiditis has been demonstrated in HCV infection in children, while only few cases of HCV-associated membranoproliferative glomerulonephritis have been described. Single reports are available in the literature reporting the anecdotal association between chronic hepatitis C and other extrahepatic manifestations such as myopathy and opsoclonus-myoclonus syndrome. Despite the low incidence of extrahepatic manifestations of chronic hepatitis C in children, overall, available data suggest a careful monitoring.http://dx.doi.org/10.1155/2012/785627 |
| spellingShingle | Giuseppe Indolfi Elisa Bartolini Biagio Olivito Chiara Azzari Massimo Resti Autoimmunity and Extrahepatic Manifestations in Treatment-Naïve Children with Chronic Hepatitis C Virus Infection Clinical and Developmental Immunology |
| title | Autoimmunity and Extrahepatic Manifestations in Treatment-Naïve Children with Chronic Hepatitis C Virus Infection |
| title_full | Autoimmunity and Extrahepatic Manifestations in Treatment-Naïve Children with Chronic Hepatitis C Virus Infection |
| title_fullStr | Autoimmunity and Extrahepatic Manifestations in Treatment-Naïve Children with Chronic Hepatitis C Virus Infection |
| title_full_unstemmed | Autoimmunity and Extrahepatic Manifestations in Treatment-Naïve Children with Chronic Hepatitis C Virus Infection |
| title_short | Autoimmunity and Extrahepatic Manifestations in Treatment-Naïve Children with Chronic Hepatitis C Virus Infection |
| title_sort | autoimmunity and extrahepatic manifestations in treatment naive children with chronic hepatitis c virus infection |
| url | http://dx.doi.org/10.1155/2012/785627 |
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