Cortical thickness correlated with peripheral inflammatory cytokines in amyotrophic lateral sclerosis
IntroductionAmyotrophic lateral sclerosis (ALS) is a rare, devastating neurodegenerative disease that affects upper and lower motor neurons, resulting in muscle atrophy, spasticity, hyperreflexia, and paralysis. Inflammation plays an important role in the development of ALS, and associated with rapi...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2024.1514554/full |
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| author | Jing Yang Jing Yang Jing Yang Wenyi Li Wenyi Li Wenyi Li Mei Tian Mei Tian Mei Tian Lei Zhang Fengping Du Fengping Du Fengping Du Xin Li Xin Li Xin Li Qi Liu Qi Liu Qi Liu Rui Li Rui Li Rui Li Zhenzhong Li Zhenzhong Li Zhenzhong Li Hui Dong Hui Dong Hui Dong Yaling Liu Yaling Liu Yaling Liu |
| author_facet | Jing Yang Jing Yang Jing Yang Wenyi Li Wenyi Li Wenyi Li Mei Tian Mei Tian Mei Tian Lei Zhang Fengping Du Fengping Du Fengping Du Xin Li Xin Li Xin Li Qi Liu Qi Liu Qi Liu Rui Li Rui Li Rui Li Zhenzhong Li Zhenzhong Li Zhenzhong Li Hui Dong Hui Dong Hui Dong Yaling Liu Yaling Liu Yaling Liu |
| author_sort | Jing Yang |
| collection | DOAJ |
| description | IntroductionAmyotrophic lateral sclerosis (ALS) is a rare, devastating neurodegenerative disease that affects upper and lower motor neurons, resulting in muscle atrophy, spasticity, hyperreflexia, and paralysis. Inflammation plays an important role in the development of ALS, and associated with rapid disease progression. Current observational studies indicate the thinning of cortical thickness in patients with ALS is associated with rapid disease progression and cognitive changes. However, the effects of inflammatory cytokines on cortical thickness in patients with ALS are unclear. Here, we investigated the relationship between inflammatory cytokines and cortical thickness in patients with ALS.MethodsWe evaluated 51 patients with ALS for inflammatory cytokines including interleukin (IL)-4, interferon (IFN)-α, IL-1β, IL-2, IL-5, IL-12, tumor necrosis factor (TNF)-α, IL-6, IL-10, IL-8, IL-17, and IFN-γ and analyzed the correlation between these indicators and the ALS functional rating scale-revised (ALSFRS-R) score or disease progression rate (ΔFS score). Twenty-six patients with ALS and 26 controls were studied using whole-cortex analysis, and post-hoc analyses were performed to examine the correlation between brain cortical thickness and ALSFRS-R or ΔFS scores.ResultsIL-4, IFN-α, IL-1β, and IL-2 levels were significantly correlated with ALSFRS-R scores, and the IL-2 level was significantly correlated with ΔFS scores. After controlling for age and sex, the ALS group had thinner cortexes in multiple clusters across the brain than the control group. Further analyses revealed that cortical thickness in the right superior temporal and lingual gyrus regions was inversely correlated with ΔFS scores. There was a significant positive correlation between the clusters in the right lingual cortex and IL-2 level.ConclusionThese results suggest cortical thickness was reduced in patients with ALS in motor and non-motor cortical areas. Inflammatory factors (especially IL-2) were correlated with cortical thickness, and both were related to the disease progression rate, suggesting IL-2 plays an important role in ALS. |
| format | Article |
| id | doaj-art-4a890685b6a74eb993d28daad0764ac6 |
| institution | Kabale University |
| issn | 1662-453X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Neuroscience |
| spelling | doaj-art-4a890685b6a74eb993d28daad0764ac62025-01-07T06:42:46ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2025-01-011810.3389/fnins.2024.15145541514554Cortical thickness correlated with peripheral inflammatory cytokines in amyotrophic lateral sclerosisJing Yang0Jing Yang1Jing Yang2Wenyi Li3Wenyi Li4Wenyi Li5Mei Tian6Mei Tian7Mei Tian8Lei Zhang9Fengping Du10Fengping Du11Fengping Du12Xin Li13Xin Li14Xin Li15Qi Liu16Qi Liu17Qi Liu18Rui Li19Rui Li20Rui Li21Zhenzhong Li22Zhenzhong Li23Zhenzhong Li24Hui Dong25Hui Dong26Hui Dong27Yaling Liu28Yaling Liu29Yaling Liu30Department of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, ChinaThe Key Laboratory of Neurology (Hebei Medical University), Ministry of Education, Shijiazhuang, Hebei, ChinaNeurological Laboratory of Hebei Province, Shijiazhuang, Hebei, ChinaDepartment of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, ChinaThe Key Laboratory of Neurology (Hebei Medical University), Ministry of Education, Shijiazhuang, Hebei, ChinaNeurological Laboratory of Hebei Province, Shijiazhuang, Hebei, ChinaDepartment of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, ChinaThe Key Laboratory of Neurology (Hebei Medical University), Ministry of Education, Shijiazhuang, Hebei, ChinaNeurological Laboratory of Hebei Province, Shijiazhuang, Hebei, ChinaDepartment of Emergency, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, ChinaDepartment of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, ChinaThe Key Laboratory of Neurology (Hebei Medical University), Ministry of Education, Shijiazhuang, Hebei, ChinaNeurological Laboratory of Hebei Province, Shijiazhuang, Hebei, ChinaDepartment of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, ChinaThe Key Laboratory of Neurology (Hebei Medical University), Ministry of Education, Shijiazhuang, Hebei, ChinaNeurological Laboratory of Hebei Province, Shijiazhuang, Hebei, ChinaDepartment of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, ChinaThe Key Laboratory of Neurology (Hebei Medical University), Ministry of Education, Shijiazhuang, Hebei, ChinaNeurological Laboratory of Hebei Province, Shijiazhuang, Hebei, ChinaDepartment of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, ChinaThe Key Laboratory of Neurology (Hebei Medical University), Ministry of Education, Shijiazhuang, Hebei, ChinaNeurological Laboratory of Hebei Province, Shijiazhuang, Hebei, ChinaDepartment of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, ChinaThe Key Laboratory of Neurology (Hebei Medical University), Ministry of Education, Shijiazhuang, Hebei, ChinaNeurological Laboratory of Hebei Province, Shijiazhuang, Hebei, ChinaDepartment of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, ChinaThe Key Laboratory of Neurology (Hebei Medical University), Ministry of Education, Shijiazhuang, Hebei, ChinaNeurological Laboratory of Hebei Province, Shijiazhuang, Hebei, ChinaDepartment of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, ChinaThe Key Laboratory of Neurology (Hebei Medical University), Ministry of Education, Shijiazhuang, Hebei, ChinaNeurological Laboratory of Hebei Province, Shijiazhuang, Hebei, ChinaIntroductionAmyotrophic lateral sclerosis (ALS) is a rare, devastating neurodegenerative disease that affects upper and lower motor neurons, resulting in muscle atrophy, spasticity, hyperreflexia, and paralysis. Inflammation plays an important role in the development of ALS, and associated with rapid disease progression. Current observational studies indicate the thinning of cortical thickness in patients with ALS is associated with rapid disease progression and cognitive changes. However, the effects of inflammatory cytokines on cortical thickness in patients with ALS are unclear. Here, we investigated the relationship between inflammatory cytokines and cortical thickness in patients with ALS.MethodsWe evaluated 51 patients with ALS for inflammatory cytokines including interleukin (IL)-4, interferon (IFN)-α, IL-1β, IL-2, IL-5, IL-12, tumor necrosis factor (TNF)-α, IL-6, IL-10, IL-8, IL-17, and IFN-γ and analyzed the correlation between these indicators and the ALS functional rating scale-revised (ALSFRS-R) score or disease progression rate (ΔFS score). Twenty-six patients with ALS and 26 controls were studied using whole-cortex analysis, and post-hoc analyses were performed to examine the correlation between brain cortical thickness and ALSFRS-R or ΔFS scores.ResultsIL-4, IFN-α, IL-1β, and IL-2 levels were significantly correlated with ALSFRS-R scores, and the IL-2 level was significantly correlated with ΔFS scores. After controlling for age and sex, the ALS group had thinner cortexes in multiple clusters across the brain than the control group. Further analyses revealed that cortical thickness in the right superior temporal and lingual gyrus regions was inversely correlated with ΔFS scores. There was a significant positive correlation between the clusters in the right lingual cortex and IL-2 level.ConclusionThese results suggest cortical thickness was reduced in patients with ALS in motor and non-motor cortical areas. Inflammatory factors (especially IL-2) were correlated with cortical thickness, and both were related to the disease progression rate, suggesting IL-2 plays an important role in ALS.https://www.frontiersin.org/articles/10.3389/fnins.2024.1514554/fullamyotrophic lateral sclerosiscortical thicknessdisease progressioninflammatory cytokinesMRI |
| spellingShingle | Jing Yang Jing Yang Jing Yang Wenyi Li Wenyi Li Wenyi Li Mei Tian Mei Tian Mei Tian Lei Zhang Fengping Du Fengping Du Fengping Du Xin Li Xin Li Xin Li Qi Liu Qi Liu Qi Liu Rui Li Rui Li Rui Li Zhenzhong Li Zhenzhong Li Zhenzhong Li Hui Dong Hui Dong Hui Dong Yaling Liu Yaling Liu Yaling Liu Cortical thickness correlated with peripheral inflammatory cytokines in amyotrophic lateral sclerosis Frontiers in Neuroscience amyotrophic lateral sclerosis cortical thickness disease progression inflammatory cytokines MRI |
| title | Cortical thickness correlated with peripheral inflammatory cytokines in amyotrophic lateral sclerosis |
| title_full | Cortical thickness correlated with peripheral inflammatory cytokines in amyotrophic lateral sclerosis |
| title_fullStr | Cortical thickness correlated with peripheral inflammatory cytokines in amyotrophic lateral sclerosis |
| title_full_unstemmed | Cortical thickness correlated with peripheral inflammatory cytokines in amyotrophic lateral sclerosis |
| title_short | Cortical thickness correlated with peripheral inflammatory cytokines in amyotrophic lateral sclerosis |
| title_sort | cortical thickness correlated with peripheral inflammatory cytokines in amyotrophic lateral sclerosis |
| topic | amyotrophic lateral sclerosis cortical thickness disease progression inflammatory cytokines MRI |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2024.1514554/full |
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