Colorectal cancer cell line-derived organoid model with stem cell properties captures the regrowing state of residual cancer cells after neoadjuvant chemotherapy

Colorectal cancer cell line-derived organoid model with stem cell properties captures the regrowing state of residual cancer cells after neoadjuvant chemotherapy

Abstract The effectiveness of colorectal cancer (CRC) therapy is limited owing to the absence of treatments targeting drug-tolerant residual cancer cells. Although neoadjuvant therapy is effective, pathological examination of residual tumors has revealed the presence of small clusters of LGR5-positi...

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Main Authors: Kiyotaka Nakano, Eiji Oki, Masaki Yamazaki, Masami Suzuki, Shigeto Kawai, Takanori Fujita, Atsuhiko Kato, Yoko Zaitsu, Tomoko Jogo, Chie Kato, Takeshi Watanabe, Eri Hashimoto, Chiyoko Nishime, Etsuko Fujii, Koji Ando, Genta Nagae, Norifumi Harimoto, Mitsuhiko Ota, Hiroshi Saeki, Hiroyuki Aburatani, Yoshihiko Maehara, Tatsumi Yamazaki
Format: Article
Language:English
Published: Nature Publishing Group 2025-06-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-025-02567-w
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