Selective vulnerability of medial temporal regions to short-term blood pressure variability and cerebral hypoperfusion in older adults
Blood pressure variability is an emerging risk factor for stroke, cognitive impairment, and dementia, possibly through links with cerebral hypoperfusion. Recent evidence suggests visit-to-visit (e.g., over months, years) blood pressure variability is related to cerebral perfusion decline in brain re...
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Elsevier
2022-03-01
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| Series: | NeuroImage: Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666956022000046 |
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| author | Isabel J. Sible Belinda Yew Shubir Dutt Yanrong Li Anna E. Blanken Jung Yun Jang Jean K. Ho Anisa J. Marshall Arunima Kapoor Aimée Gaubert Katherine J. Bangen Virginia E. Sturm Xingfeng Shao Danny J. Wang Daniel A. Nation |
| author_facet | Isabel J. Sible Belinda Yew Shubir Dutt Yanrong Li Anna E. Blanken Jung Yun Jang Jean K. Ho Anisa J. Marshall Arunima Kapoor Aimée Gaubert Katherine J. Bangen Virginia E. Sturm Xingfeng Shao Danny J. Wang Daniel A. Nation |
| author_sort | Isabel J. Sible |
| collection | DOAJ |
| description | Blood pressure variability is an emerging risk factor for stroke, cognitive impairment, and dementia, possibly through links with cerebral hypoperfusion. Recent evidence suggests visit-to-visit (e.g., over months, years) blood pressure variability is related to cerebral perfusion decline in brain regions vulnerable to Alzheimer's disease. However, less is known about relationships between short-term (e.g., <24 h) blood pressure variability and regional cerebral perfusion, and whether these relationships may differ by age. We investigated short-term blood pressure variability and concurrent regional cerebral microvascular perfusion in a sample of community-dwelling older adults without history of dementia or stroke and healthy younger adults. Blood pressure was collected continuously during perfusion MRI. Cerebral blood flow was determined for several brain regions implicated in cerebrovascular dysfunction in Alzheimer's disease. Elevated systolic blood pressure variability was related to lower levels of concurrent cerebral perfusion in medial temporal regions: hippocampus (ß = −0.60 [95% CI -0.90, −0.30]; p < .001), parahippocampal gyrus (ß = −0.57 [95% CI -0.89, −0.25]; p = .001), entorhinal cortex (ß = −0.42 [95% CI -0.73, −0.12]; p = .009), and perirhinal cortex (ß = −0.37 [95% CI -0.72, −0.03]; p = .04), and not in other regions, and in older adults only. Findings suggest a possible age-related selective vulnerability of the medial temporal lobes to hypoperfusion in the context of short-term blood pressure fluctuations, independent of average blood pressure, white matter hyperintensities, and gray matter volume, which may underpin the increased risk for dementia associated with elevated BPV.1 |
| format | Article |
| id | doaj-art-4a7adb932d9342ff9c9b516feb6c4d1d |
| institution | DOAJ |
| issn | 2666-9560 |
| language | English |
| publishDate | 2022-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Reports |
| spelling | doaj-art-4a7adb932d9342ff9c9b516feb6c4d1d2025-08-20T03:03:58ZengElsevierNeuroImage: Reports2666-95602022-03-012110008010.1016/j.ynirp.2022.100080Selective vulnerability of medial temporal regions to short-term blood pressure variability and cerebral hypoperfusion in older adultsIsabel J. Sible0Belinda Yew1Shubir Dutt2Yanrong Li3Anna E. Blanken4Jung Yun Jang5Jean K. Ho6Anisa J. Marshall7Arunima Kapoor8Aimée Gaubert9Katherine J. Bangen10Virginia E. Sturm11Xingfeng Shao12Danny J. Wang13Daniel A. Nation14Department of Psychology, University of Southern California, Los Angeles, CA, 90089, USADepartment of Psychology, University of Southern California, Los Angeles, CA, 90089, USADepartment of Psychology, University of Southern California, Los Angeles, CA, 90089, USA; Davis School of Gerontology, University of Southern California, Los Angeles, CA, 90089, USAInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA, 92697, USADepartment of Psychology, University of Southern California, Los Angeles, CA, 90089, USAInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA, 92697, USAInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA, 92697, USADepartment of Psychology, University of Southern California, Los Angeles, CA, 90089, USADepartment of Psychological Science, University of California Irvine, Irvine, CA, 92697, USAInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA, 92697, USAResearch Service, Veteran Affairs San Diego Healthcare System, San Diego, CA, 92161, USA; Department of Psychiatry, University of California, San Diego, La Jolla, CA, 92093, USADepartment of Neurology, University of California, San Francisco, CA, 94158, USA; Department of Psychiatry, University of California, San Francisco, CA, 94158, USA; Global Brain Health Institute, University of California, San Francisco, CA, 94158, USALaboratory of Functional MRI Technology, Mark and Mary Stevens Neuroimaging and Informatics Institute, University of Southern California, Los Angeles, CA, 90033, USALaboratory of Functional MRI Technology, Mark and Mary Stevens Neuroimaging and Informatics Institute, University of Southern California, Los Angeles, CA, 90033, USAInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA, 92697, USA; Department of Psychological Science, University of California Irvine, Irvine, CA, 92697, USA; Corresponding author. University of California Irvine Department of Psychological Science 4201 Social and Behavioral Sciences Gateway Irvine, CA, USABlood pressure variability is an emerging risk factor for stroke, cognitive impairment, and dementia, possibly through links with cerebral hypoperfusion. Recent evidence suggests visit-to-visit (e.g., over months, years) blood pressure variability is related to cerebral perfusion decline in brain regions vulnerable to Alzheimer's disease. However, less is known about relationships between short-term (e.g., <24 h) blood pressure variability and regional cerebral perfusion, and whether these relationships may differ by age. We investigated short-term blood pressure variability and concurrent regional cerebral microvascular perfusion in a sample of community-dwelling older adults without history of dementia or stroke and healthy younger adults. Blood pressure was collected continuously during perfusion MRI. Cerebral blood flow was determined for several brain regions implicated in cerebrovascular dysfunction in Alzheimer's disease. Elevated systolic blood pressure variability was related to lower levels of concurrent cerebral perfusion in medial temporal regions: hippocampus (ß = −0.60 [95% CI -0.90, −0.30]; p < .001), parahippocampal gyrus (ß = −0.57 [95% CI -0.89, −0.25]; p = .001), entorhinal cortex (ß = −0.42 [95% CI -0.73, −0.12]; p = .009), and perirhinal cortex (ß = −0.37 [95% CI -0.72, −0.03]; p = .04), and not in other regions, and in older adults only. Findings suggest a possible age-related selective vulnerability of the medial temporal lobes to hypoperfusion in the context of short-term blood pressure fluctuations, independent of average blood pressure, white matter hyperintensities, and gray matter volume, which may underpin the increased risk for dementia associated with elevated BPV.1http://www.sciencedirect.com/science/article/pii/S2666956022000046Blood pressure variabilityCerebral hypoperfusionAgingMedial temporal lobes |
| spellingShingle | Isabel J. Sible Belinda Yew Shubir Dutt Yanrong Li Anna E. Blanken Jung Yun Jang Jean K. Ho Anisa J. Marshall Arunima Kapoor Aimée Gaubert Katherine J. Bangen Virginia E. Sturm Xingfeng Shao Danny J. Wang Daniel A. Nation Selective vulnerability of medial temporal regions to short-term blood pressure variability and cerebral hypoperfusion in older adults NeuroImage: Reports Blood pressure variability Cerebral hypoperfusion Aging Medial temporal lobes |
| title | Selective vulnerability of medial temporal regions to short-term blood pressure variability and cerebral hypoperfusion in older adults |
| title_full | Selective vulnerability of medial temporal regions to short-term blood pressure variability and cerebral hypoperfusion in older adults |
| title_fullStr | Selective vulnerability of medial temporal regions to short-term blood pressure variability and cerebral hypoperfusion in older adults |
| title_full_unstemmed | Selective vulnerability of medial temporal regions to short-term blood pressure variability and cerebral hypoperfusion in older adults |
| title_short | Selective vulnerability of medial temporal regions to short-term blood pressure variability and cerebral hypoperfusion in older adults |
| title_sort | selective vulnerability of medial temporal regions to short term blood pressure variability and cerebral hypoperfusion in older adults |
| topic | Blood pressure variability Cerebral hypoperfusion Aging Medial temporal lobes |
| url | http://www.sciencedirect.com/science/article/pii/S2666956022000046 |
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