Assessing SPECT/CT for the identification of cartilage lesions in the knee joint: A systematic review
Background: Single-photon emission computerised tomography with conventional computer tomography (SPECT/CT) is an emerging technology which may hold clinical value for the identification of cartilage lesions in the knee joint. The intensity and distribution of SPECT/CT uptake tracer may identify phy...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-03-01
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| Series: | Osteoarthritis and Cartilage Open |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2665913125000135 |
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| _version_ | 1823861176292868096 |
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| author | Larissa Rix Samuel Tushingham Karina Wright Martyn Snow |
| author_facet | Larissa Rix Samuel Tushingham Karina Wright Martyn Snow |
| author_sort | Larissa Rix |
| collection | DOAJ |
| description | Background: Single-photon emission computerised tomography with conventional computer tomography (SPECT/CT) is an emerging technology which may hold clinical value for the identification of cartilage lesions in the knee joint. The intensity and distribution of SPECT/CT uptake tracer may identify physiological and structural information in the absence of structural change on other imaging modalities. Objectives: To systematically assess the utility of SPECT/CT in the detection of chondral lesions within the knee joint, in patients presenting with knee pain, with or without structural change. Results: PubMed, Science Direct, Web of Knowledge, and NHS databases were searched for English language articles focusing on the diagnostic value of SPECT/CT for knee chondral lesions and knee pain. Animal studies, cadaver studies, comparator radiological technique other than SPECT/CT or patients with a pathology other than knee chondral lesions were excluded. From the search, 11,982 manuscripts were identified, and screened for relevance. Seven studies were identified and scored low on QUADAS-2 bias review. SPECT/CT correlated with lesions found on other imaging modalities and during intraoperative assessment. Furthermore, in some cases, SPECT/CT out-performed other modalities in the detection of cartilage lesions. Conclusion: Evidence suggests SPECT/CT may be a useful tool for the detection and localisation of cartilage lesions, particularly in discrepant cases when there is an absence of lesions on other imaging modalities, or a lack of correlation with patients’ symptoms. Further studies are required to confirm the conclusions of this review. |
| format | Article |
| id | doaj-art-4a79c70ea3f74aa5a07e547e471c30cb |
| institution | Kabale University |
| issn | 2665-9131 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Osteoarthritis and Cartilage Open |
| spelling | doaj-art-4a79c70ea3f74aa5a07e547e471c30cb2025-02-10T04:34:54ZengElsevierOsteoarthritis and Cartilage Open2665-91312025-03-0171100577Assessing SPECT/CT for the identification of cartilage lesions in the knee joint: A systematic reviewLarissa Rix0Samuel Tushingham1Karina Wright2Martyn Snow3The Robert Jones and Agnes Hunt Orthopaedic Hospital Foundation Trust, Oswestry, SY10 7AG, United Kingdom; Centre for Regenerative Medicine Research, Keele University, Staffordshire, ST5 5BG, United Kingdom; Corresponding author. Centre for Regenerative Medicine Research, Keele University, Staffordshire, ST5 5BG, United Kingdom.The Shrewsbury and Telford NHS Trust, Shrewsbury, United KingdomThe Robert Jones and Agnes Hunt Orthopaedic Hospital Foundation Trust, Oswestry, SY10 7AG, United Kingdom; Centre for Regenerative Medicine Research, Keele University, Staffordshire, ST5 5BG, United KingdomThe Robert Jones and Agnes Hunt Orthopaedic Hospital Foundation Trust, Oswestry, SY10 7AG, United Kingdom; Centre for Regenerative Medicine Research, Keele University, Staffordshire, ST5 5BG, United Kingdom; The Royal Orthopaedic Hospital, Birmingham, United KingdomBackground: Single-photon emission computerised tomography with conventional computer tomography (SPECT/CT) is an emerging technology which may hold clinical value for the identification of cartilage lesions in the knee joint. The intensity and distribution of SPECT/CT uptake tracer may identify physiological and structural information in the absence of structural change on other imaging modalities. Objectives: To systematically assess the utility of SPECT/CT in the detection of chondral lesions within the knee joint, in patients presenting with knee pain, with or without structural change. Results: PubMed, Science Direct, Web of Knowledge, and NHS databases were searched for English language articles focusing on the diagnostic value of SPECT/CT for knee chondral lesions and knee pain. Animal studies, cadaver studies, comparator radiological technique other than SPECT/CT or patients with a pathology other than knee chondral lesions were excluded. From the search, 11,982 manuscripts were identified, and screened for relevance. Seven studies were identified and scored low on QUADAS-2 bias review. SPECT/CT correlated with lesions found on other imaging modalities and during intraoperative assessment. Furthermore, in some cases, SPECT/CT out-performed other modalities in the detection of cartilage lesions. Conclusion: Evidence suggests SPECT/CT may be a useful tool for the detection and localisation of cartilage lesions, particularly in discrepant cases when there is an absence of lesions on other imaging modalities, or a lack of correlation with patients’ symptoms. Further studies are required to confirm the conclusions of this review.http://www.sciencedirect.com/science/article/pii/S2665913125000135ImagingDiagnosticsCartilage lesionsKnee painSPECT/CTNuclear medicine |
| spellingShingle | Larissa Rix Samuel Tushingham Karina Wright Martyn Snow Assessing SPECT/CT for the identification of cartilage lesions in the knee joint: A systematic review Osteoarthritis and Cartilage Open Imaging Diagnostics Cartilage lesions Knee pain SPECT/CT Nuclear medicine |
| title | Assessing SPECT/CT for the identification of cartilage lesions in the knee joint: A systematic review |
| title_full | Assessing SPECT/CT for the identification of cartilage lesions in the knee joint: A systematic review |
| title_fullStr | Assessing SPECT/CT for the identification of cartilage lesions in the knee joint: A systematic review |
| title_full_unstemmed | Assessing SPECT/CT for the identification of cartilage lesions in the knee joint: A systematic review |
| title_short | Assessing SPECT/CT for the identification of cartilage lesions in the knee joint: A systematic review |
| title_sort | assessing spect ct for the identification of cartilage lesions in the knee joint a systematic review |
| topic | Imaging Diagnostics Cartilage lesions Knee pain SPECT/CT Nuclear medicine |
| url | http://www.sciencedirect.com/science/article/pii/S2665913125000135 |
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