Identification of TMEM53 as a novel SADS-CoV restriction factor that targets viral RNA-dependent RNA polymerase

Identification of TMEM53 as a novel SADS-CoV restriction factor that targets viral RNA-dependent RNA polymerase

Zoonotic transmission of coronaviruses (CoVs) poses a serious public health threat. Swine acute diarrhea syndrome coronavirus (SADS-CoV), originating from a bat HKU2-related CoV, causes devastating swine diseases and poses a high risk of spillover to humans. Currently, licensed therapeutics that can...

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Bibliographic Details
Main Authors: Yu-Lin Yao, Yun Luo, Qi Wang, Rong Geng, Ying Chen, Mei-Qin Liu, Bei Li, Jing Chen, Chun-Guang Wu, Jing-Kun Jia, Jing-Yi Luo, Yan-Tong He, Ting-Ting Jiang, Yan Zhu, Ben Hu, Peng Zhou, Zheng-Li Shi
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:Emerging Microbes and Infections
Subjects:
TMEM53
SADS-CoV
RdRp activity
HKU2-related CoVs
coronavirus zoonosis
Online Access:https://www.tandfonline.com/doi/10.1080/22221751.2023.2249120
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