Mitomycin-C-Induced TTP/HUS Treated Successfully with Rituximab: Case Report and Review of the Literature
Microangiopathic hemolytic anemia (MAHA), thrombocytopenia, fever, renal failure, and neurologic symptoms comprise the cardinal features of thrombotic thrombocytopenic purpura and hemolytic uremic syndrome. Etiologies can include medications, infections, cancers, or transplantation. We present a pat...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2013/130978 |
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| _version_ | 1832550691664560128 |
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| author | Gunjan Shah Hanah Yamin Hedy Smith |
| author_facet | Gunjan Shah Hanah Yamin Hedy Smith |
| author_sort | Gunjan Shah |
| collection | DOAJ |
| description | Microangiopathic hemolytic anemia (MAHA), thrombocytopenia, fever, renal failure, and neurologic symptoms comprise the cardinal features of thrombotic thrombocytopenic purpura and hemolytic uremic syndrome. Etiologies can include medications, infections, cancers, or transplantation. We present a patient with a history of rectal cancer treated with mitomycin-C who developed MAHA, acute kidney injury, and thrombocytopenia 6 months after completing therapy and to did not respond the plasmapheresis or steroids. She was treated with four weekly doses of rituximab with full recovery. |
| format | Article |
| id | doaj-art-4a779b1af032426d97307d91dcd16028 |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-4a779b1af032426d97307d91dcd160282025-02-03T06:06:02ZengWileyCase Reports in Hematology2090-65602090-65792013-01-01201310.1155/2013/130978130978Mitomycin-C-Induced TTP/HUS Treated Successfully with Rituximab: Case Report and Review of the LiteratureGunjan Shah0Hanah Yamin1Hedy Smith2Tufts Medical Center, 800 Washington Street, P.O. Box 245, Boston, MA 02108, USAJordan Hospital, 275 Sandwich Street, Plymouth, MA 02360, USATufts Medical Center, 800 Washington Street, P.O. Box 245, Boston, MA 02108, USAMicroangiopathic hemolytic anemia (MAHA), thrombocytopenia, fever, renal failure, and neurologic symptoms comprise the cardinal features of thrombotic thrombocytopenic purpura and hemolytic uremic syndrome. Etiologies can include medications, infections, cancers, or transplantation. We present a patient with a history of rectal cancer treated with mitomycin-C who developed MAHA, acute kidney injury, and thrombocytopenia 6 months after completing therapy and to did not respond the plasmapheresis or steroids. She was treated with four weekly doses of rituximab with full recovery.http://dx.doi.org/10.1155/2013/130978 |
| spellingShingle | Gunjan Shah Hanah Yamin Hedy Smith Mitomycin-C-Induced TTP/HUS Treated Successfully with Rituximab: Case Report and Review of the Literature Case Reports in Hematology |
| title | Mitomycin-C-Induced TTP/HUS Treated Successfully with Rituximab: Case Report and Review of the Literature |
| title_full | Mitomycin-C-Induced TTP/HUS Treated Successfully with Rituximab: Case Report and Review of the Literature |
| title_fullStr | Mitomycin-C-Induced TTP/HUS Treated Successfully with Rituximab: Case Report and Review of the Literature |
| title_full_unstemmed | Mitomycin-C-Induced TTP/HUS Treated Successfully with Rituximab: Case Report and Review of the Literature |
| title_short | Mitomycin-C-Induced TTP/HUS Treated Successfully with Rituximab: Case Report and Review of the Literature |
| title_sort | mitomycin c induced ttp hus treated successfully with rituximab case report and review of the literature |
| url | http://dx.doi.org/10.1155/2013/130978 |
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