Perspectives of HPV vaccination among young adults: a qualitative systematic review and evidence synthesis protocol

Introduction Human papillomavirus (HPV) is the causative agent of nearly all cervical cancers. Despite the proven safety and efficacy of HPV vaccines in preventing HPV-related cancers, the global vaccine coverage rate is estimated to only be 15%. HPV vaccine coverage rates are more actively tracked...

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Main Authors: Purnima Madhivanan, Jonathan Smith, Namoonga M Mantina, Flavia Nakayima Miiro, Deborah Jean McClelland, Priscilla Anne Magrath
Format: Article
Language:English
Published: BMJ Publishing Group 2023-12-01
Series:BMJ Open
Online Access:https://bmjopen.bmj.com/content/13/12/e076234.full
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author Purnima Madhivanan
Jonathan Smith
Namoonga M Mantina
Flavia Nakayima Miiro
Deborah Jean McClelland
Priscilla Anne Magrath
author_facet Purnima Madhivanan
Jonathan Smith
Namoonga M Mantina
Flavia Nakayima Miiro
Deborah Jean McClelland
Priscilla Anne Magrath
author_sort Purnima Madhivanan
collection DOAJ
description Introduction Human papillomavirus (HPV) is the causative agent of nearly all cervical cancers. Despite the proven safety and efficacy of HPV vaccines in preventing HPV-related cancers, the global vaccine coverage rate is estimated to only be 15%. HPV vaccine coverage rates are more actively tracked and reported for adolescents 17 years and younger but there is still a critical window of opportunity to intervene and promote HPV vaccination among young adults aged 18–26 years who are still eligible to be vaccinated. This protocol for a qualitative evidence synthesis aims to review perspectives of HPV vaccination among young adults (18–26 years) and identify facilitators and barriers that influence HPV vaccination uptake and decision-making.Methods and analysis Seven databases will be searched from 1 January 2006 to the date of final search. For inclusion, studies must report HPV vaccination perspectives of young adults aged 18–26 years and use qualitative study methods or analysis techniques. Studies will be screened in a two-stage process guided by the eligibility criteria. Final included studies will be evaluated for methodological strengths and limitations using the Critical Appraisal Skills Programme quality assessment tool for qualitative studies. After data extraction, framework analysis will be used to analyse the data applying the socioecological model. Finally, the Grading of Recommendations Assessment, Development and Evaluation - Confidence in the Evidence from Reviews of Qualitative research will be applied to evaluate the confidence in synthesised qualitative findings. The methodology of this review follows the Cochrane Handbook guidelines on qualitative evidence syntheses.Ethics and dissemination Formal ethical approval is not required for this study. Findings will be disseminated through peer-reviewed publications, conference presentations and professional networks.PROSPERO registration number CRD42023417052.
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spelling doaj-art-4a70f9bdacd54bdd96ea229c22172f5d2025-08-20T01:48:37ZengBMJ Publishing GroupBMJ Open2044-60552023-12-01131210.1136/bmjopen-2023-076234Perspectives of HPV vaccination among young adults: a qualitative systematic review and evidence synthesis protocolPurnima Madhivanan0Jonathan Smith1Namoonga M Mantina2Flavia Nakayima Miiro3Deborah Jean McClelland4Priscilla Anne Magrath5The University of Arizona Mel and Enid Zuckerman College of Public Health, Tucson, Arizona, USANIHR Greater Manchester Patient Safety Research Collaboration, School of Health Sciences, University of Manchester, Manchester, UKThe University of Arizona Mel and Enid Zuckerman College of Public Health, Tucson, Arizona, USAThe University of Arizona Mel and Enid Zuckerman College of Public Health, Tucson, Arizona, USAHealth Sciences Library, The University of Arizona, Tucson, Arizona, USAThe University of Arizona Mel and Enid Zuckerman College of Public Health, Tucson, Arizona, USAIntroduction Human papillomavirus (HPV) is the causative agent of nearly all cervical cancers. Despite the proven safety and efficacy of HPV vaccines in preventing HPV-related cancers, the global vaccine coverage rate is estimated to only be 15%. HPV vaccine coverage rates are more actively tracked and reported for adolescents 17 years and younger but there is still a critical window of opportunity to intervene and promote HPV vaccination among young adults aged 18–26 years who are still eligible to be vaccinated. This protocol for a qualitative evidence synthesis aims to review perspectives of HPV vaccination among young adults (18–26 years) and identify facilitators and barriers that influence HPV vaccination uptake and decision-making.Methods and analysis Seven databases will be searched from 1 January 2006 to the date of final search. For inclusion, studies must report HPV vaccination perspectives of young adults aged 18–26 years and use qualitative study methods or analysis techniques. Studies will be screened in a two-stage process guided by the eligibility criteria. Final included studies will be evaluated for methodological strengths and limitations using the Critical Appraisal Skills Programme quality assessment tool for qualitative studies. After data extraction, framework analysis will be used to analyse the data applying the socioecological model. Finally, the Grading of Recommendations Assessment, Development and Evaluation - Confidence in the Evidence from Reviews of Qualitative research will be applied to evaluate the confidence in synthesised qualitative findings. The methodology of this review follows the Cochrane Handbook guidelines on qualitative evidence syntheses.Ethics and dissemination Formal ethical approval is not required for this study. Findings will be disseminated through peer-reviewed publications, conference presentations and professional networks.PROSPERO registration number CRD42023417052.https://bmjopen.bmj.com/content/13/12/e076234.full
spellingShingle Purnima Madhivanan
Jonathan Smith
Namoonga M Mantina
Flavia Nakayima Miiro
Deborah Jean McClelland
Priscilla Anne Magrath
Perspectives of HPV vaccination among young adults: a qualitative systematic review and evidence synthesis protocol
BMJ Open
title Perspectives of HPV vaccination among young adults: a qualitative systematic review and evidence synthesis protocol
title_full Perspectives of HPV vaccination among young adults: a qualitative systematic review and evidence synthesis protocol
title_fullStr Perspectives of HPV vaccination among young adults: a qualitative systematic review and evidence synthesis protocol
title_full_unstemmed Perspectives of HPV vaccination among young adults: a qualitative systematic review and evidence synthesis protocol
title_short Perspectives of HPV vaccination among young adults: a qualitative systematic review and evidence synthesis protocol
title_sort perspectives of hpv vaccination among young adults a qualitative systematic review and evidence synthesis protocol
url https://bmjopen.bmj.com/content/13/12/e076234.full
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