Daidzein alleviates skin fibrosis by suppressing TGF-β1 signaling pathway via targeting PKM2

Daidzein alleviates skin fibrosis by suppressing TGF-β1 signaling pathway via targeting PKM2

Abstract Skin fibrosis including keloids, which are characterized including excessive deposition, abnormal proliferation, aggressiveness, and migration of the extracellular matrix of dermal fibroblasts. TGF-β signaling is a classical pro-fibrotic pathway, and it plays a crucial part in the occurrenc...

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Main Authors: Xiaowei Guo, Wenqi Li, Wei Ma, Yuming Liu, Zhigang Liu, Ran Jiao, Zhongyi Yang, Tiantian Zhang, Hongliang Wu, Xiaoyu Ai, Xiaoting Gu, Wendi Wang, Honggang Zhou, Xiaohe Li, Cheng Yang
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Scientific Reports
Subjects:
Skin fibrosis
Keloid
TGF-β signaling
Daidzein
PKM2
Online Access:https://doi.org/10.1038/s41598-025-93007-3
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