Colonic Adenocarcinoma at Advanced Stage in Adolescence: Report of 2 Cases
Background. Carcinoma of colon is rare in children and adolescents. The staging criteria of the carcinoma is the same as those for adults. However, the pathogenetic background in pediatric cases is different from adults and usually involves mismatch repair gene mutations or familial polyposis syndro...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Case Reports in Pathology |
| Online Access: | http://dx.doi.org/10.1155/2020/1848367 |
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| _version_ | 1850109439110021120 |
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| author | Divya S. Vundamati Xiuxu Chen Vivekanand Singh |
| author_facet | Divya S. Vundamati Xiuxu Chen Vivekanand Singh |
| author_sort | Divya S. Vundamati |
| collection | DOAJ |
| description | Background. Carcinoma of colon is rare in children and adolescents. The staging criteria of the carcinoma is the same as those for adults. However, the pathogenetic background in pediatric cases is different from adults and usually involves mismatch repair gene mutations or familial polyposis syndromes. Case report. We describe two adolescents diagnosed with advanced stage colon carcinoma and discuss the histological appearance, testing for mismatch repair genes and contrast- it with carcinoma occurring in the setting of familial polyposis syndrome. Conclusion. Colonic carcinoma occurring in pediatric patients should prompt a work-up for mismatch repair gene mutation status. Despite higher stage of presentation, some of the pediatric patients may respond favorably to chemotherapy and surgical resection. |
| format | Article |
| id | doaj-art-4a6fcd2064e648dfaf7067ad4cdb33e0 |
| institution | OA Journals |
| issn | 2090-6781 2090-679X |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pathology |
| spelling | doaj-art-4a6fcd2064e648dfaf7067ad4cdb33e02025-08-20T02:38:05ZengWileyCase Reports in Pathology2090-67812090-679X2020-01-01202010.1155/2020/18483671848367Colonic Adenocarcinoma at Advanced Stage in Adolescence: Report of 2 CasesDivya S. Vundamati0Xiuxu Chen1Vivekanand Singh2University of Missouri School of Medicine, Kansas City, MO 64108, USADepartment of Pathology and Laboratory Medicine, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160, USAUniversity of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX-75390, USABackground. Carcinoma of colon is rare in children and adolescents. The staging criteria of the carcinoma is the same as those for adults. However, the pathogenetic background in pediatric cases is different from adults and usually involves mismatch repair gene mutations or familial polyposis syndromes. Case report. We describe two adolescents diagnosed with advanced stage colon carcinoma and discuss the histological appearance, testing for mismatch repair genes and contrast- it with carcinoma occurring in the setting of familial polyposis syndrome. Conclusion. Colonic carcinoma occurring in pediatric patients should prompt a work-up for mismatch repair gene mutation status. Despite higher stage of presentation, some of the pediatric patients may respond favorably to chemotherapy and surgical resection.http://dx.doi.org/10.1155/2020/1848367 |
| spellingShingle | Divya S. Vundamati Xiuxu Chen Vivekanand Singh Colonic Adenocarcinoma at Advanced Stage in Adolescence: Report of 2 Cases Case Reports in Pathology |
| title | Colonic Adenocarcinoma at Advanced Stage in Adolescence: Report of 2 Cases |
| title_full | Colonic Adenocarcinoma at Advanced Stage in Adolescence: Report of 2 Cases |
| title_fullStr | Colonic Adenocarcinoma at Advanced Stage in Adolescence: Report of 2 Cases |
| title_full_unstemmed | Colonic Adenocarcinoma at Advanced Stage in Adolescence: Report of 2 Cases |
| title_short | Colonic Adenocarcinoma at Advanced Stage in Adolescence: Report of 2 Cases |
| title_sort | colonic adenocarcinoma at advanced stage in adolescence report of 2 cases |
| url | http://dx.doi.org/10.1155/2020/1848367 |
| work_keys_str_mv | AT divyasvundamati colonicadenocarcinomaatadvancedstageinadolescencereportof2cases AT xiuxuchen colonicadenocarcinomaatadvancedstageinadolescencereportof2cases AT vivekanandsingh colonicadenocarcinomaatadvancedstageinadolescencereportof2cases |